HER2 activation plays a crucial role in promoting tumor proliferation and survival in NSCLC. Driven by oncogenic downstream signaling pathways, HER2 overexpression and gene amplification lead to the formation of heterodimers and activation of key signaling cascades. Additionally, HER2 mutations are

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This slideshow provides an overview of tumor classification, nomenclature, and key concepts in pathology. It covers the definitions of neoplasm, tumor, and oncology, the classification of tumors into benign and malignant categories, as well as the importance of stroma in tumor behavior. It also expl

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Discover the best spine tumor treatment at Medspine, the leading hospital with top surgeon and specialist in Medavakkam, Perumbakkam, Royapettah, Chennai.

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Chronic myeloid leukemia (CML), or chronic myelogenous leukemia, is a slow-growing form of cancer that affects the bone marrow and blood. Like acute myeloid leukemia, CML originates in the myeloid cells. When functioning properly, myeloid cells produce mature red blood cells, platelets and non-lymph

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Explore the fundamentals of electricity and circuits, including circuit components, cells, batteries, types of cells, primary vs. secondary cells, dry vs. wet cells, and ratings. Learn about the relevance of this knowledge in engineering and certifications like NABCEP PV Associate. Discover the work

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Phage DNA can be introduced into bacterial cells through two methods: transfection and in vitro packaging. Transfection involves mixing purified phage DNA with competent E. coli cells, inducing DNA uptake via heat shock. In vitro packaging utilizes proteins coded by the phage genome, which can be pr

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Grading and staging are crucial in determining the aggressiveness and extent of malignant tumors. Grading involves assessing the level of malignancy based on cell differentiation and mitotic activity, while staging considers the size of the tumor, lymph node involvement, and presence of metastases.

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Your blood, consisting of red blood cells, white blood cells, platelets, and plasma, plays a crucial role in transporting substances like oxygen, nutrients, and waste products throughout your body. Red blood cells are specialized for oxygen transport due to their unique adaptations, while white bloo

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This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with

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WAGR syndrome is a rare genetic condition associated with Wilms Tumor, aniridia, and developmental delays. Wilms Tumor is a form of kidney cancer mostly affecting children and is linked to genetic disorders like WAGR syndrome. The risk of Wilms Tumor is higher in children with WAGR syndrome, with po

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Stem cells are undifferentiated cells with the unique ability to develop into various specialized cell types, making them valuable for medical applications. Dr. J. Gowri explores the classification, features, and properties of stem cells, shedding light on their self-renewal and potency. These cells

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Stem cells are unique cells that have the potential to develop into various types of cells in the body. They play a crucial role in renewing and repairing tissues, offering hope for treating various medical conditions. While adult stem cells can differentiate into limited cell types, embryonic stem

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This detailed histological study covers the structure and function of the thyroid and parathyroid glands. It includes information on the stroma, parenchyma, follicular cells, parafollicular cells, and the microscopic structure of the parathyroid gland. The article also delves into the functions of v

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Positron Emission Tomography (PET) is a medical imaging technique focusing on metabolic differences in the body. By using positron-emitting radioisotopes, PET can detect how molecules are taken up by healthy and cancerous cells, aiding in accurate tumor localization with lower doses. The evolution o

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Research collaboration aimed to enhance locoregional tumor control and reduce distant failure by combining charged particles irradiation and anticancer drug Epothilone B in cultured human tumor cells from Milano and Roma. The study explores the impact on clonogenic survival, growth curves, and deter

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Observing well-defined cells with clear presence of cell walls would help conclude that the cells are plant cells, distinguishable from animal cells by the absence of cell walls. The detection of nuclei within each cell is a common characteristic observed in both plant and animal cells.

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The Gamma Knife Stereotactic Radiosurgery is a precise and effective treatment method where highly focused radiation beams are used to target tumors and abnormalities in the brain. It does not remove the tumor directly but affects DNA, cell growth, and blood vessels. The procedure involves three mai

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NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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Meiosis is a crucial process in sexually reproducing organisms where cells divide to produce sex cells with half the normal number of chromosomes. This ensures genetic variation in offspring. Meiosis takes place in specific cells of an organism with paired chromosomes (diploid cells), leading to the

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Tissue repair involves complex mechanisms like regeneration by parenchymal cells or fibrosis leading to scar formation. Inflammatory cells play a crucial role in tissue repair, along with processes like ECM synthesis and cell migration. Different types of cells in the body have varying regenerative

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The body's response to injury involves two main processes of wound healing - regeneration and repair. Regeneration involves proliferation of parenchymatous cells, while repair results in fibrosis and scarring by proliferation of connective tissue. Different types of cells play varying roles in the h

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This study by Shyamala Maherswaran, Ph.D., and team focuses on characterizing mutations in EGFR in circulating tumor cells using SARMS assay and CTC-chip. The research investigates the effectiveness of these non-invasive methods in analyzing tumors and explores the role of the T790M mutation in resp

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This collection of supplementary figures provides detailed flow cytometry data on immune cell populations, including CD4+ T cells, CD8+ T cells, tumor-associated macrophages, and more. The figures also include information on immune checkpoint molecules like PD-L1 and TIGIT. Each figure presents spec

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Vestibular schwannoma, also known as acoustic neuroma, is a common tumor in the cerebellopontine angle. It can be sporadic or associated with neurofibromatosis type 2. Patients typically present with hearing loss and tinnitus, which may be gradual or sudden. Grading systems like Koos, Ojemann, and J

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Neoplasia encompasses abnormal tissue growth that can be benign or malignant. This article explores neoplastic terms, tumor classifications, cancer staging, and genetic factors in cancer development. Gain insights into the characteristics of benign tumors, the biology of cancer including carcinogene

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Understanding the classification of tumors is crucial in the field of pathology. This detailed overview covers the definitions of neoplasia and tumors, the differentiation between benign and malignant tumors, nomenclature, and characteristics of various tumor types. It discusses the behaviors of ben

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Cells are the fundamental units of life, but viruses are an exception as they lack cells. Eukaryotic cells have a defined nucleus with a nuclear membrane housing chromosomes, while prokaryotic cells lack a membrane-bound nucleus and other organelles. Eukaryotic cells are larger, containing membrane-

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Prokaryotic cells divide through binary fission, while eukaryotic cells undergo mitosis with nuclear division and cytokinesis. Prokaryotic cells lack a nucleus and divide by replicating DNA and forming two identical daughter cells. Eukaryotic chromosomes, associated with histone proteins, undergo co

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Stem cell transplantation involves addressing the issue of immune cells failing to recognize and eliminate tumor cells, known as "The Bad Boys." By removing the dormant immune cells and replacing them with new ones from a compatible donor, the therapy aims to empower the immune system to target and

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The small intestine is a key organ in the digestive system responsible for the digestion and absorption of nutrients. It is divided into the duodenum, jejunum, and ileum, each with specific functions and structures like plicae circulares, villi, microvilli, and crypts of Lieberkühn. The intestinal

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This tutorial, prepared by the International Working Group for TIL in breast cancer, provides guidelines for pathologists on the standardized evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer based on H&E slides of core biopsies or tumor resections. It details steps such as defini

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Craniopharyngioma is a complex intracranial tumor with a rich historical background dating back to the early 20th century. Initially described by McLean, Frazier, Alpes, and famously studied by Cushing, this tumor continues to be a subject of debate and controversy in terms of treatment approaches a

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This study explores the problem of finding the largest area axis-aligned B-empty rectangle containing n red points and m blue points. The research discusses various extensions to the original problem, such as the Blue Rectangles problem and the Outliers Problem, aiming to achieve efficient solutions

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The lymphatic system plays a crucial role in returning leaked fluids back to the blood, protecting the body from foreign materials, and supporting immune surveillance. It consists of lymphoid cells such as T and B lymphocytes, macrophages, dendritic cells, and reticular cells that work together to d

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Stem cells play a crucial role in animal cells, offering the potential to differentiate into various cell types. Totipotent stem cells are the most versatile, capable of developing into any cell type in the embryo, including extra-embryonic cells. Pluripotent stem cells can give rise to all body cel

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Cancer's complex evolution introduces challenges in treatment response. B-SCITE aims to enhance tumor phylogeny inference by integrating bulk sequencing and single-cell data using a probabilistic approach. It addresses the complexity of tumor cell populations and potential treatment failure causes.

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Commercial cells and batteries are essential sources of electrochemical electricity. There are two main types: primary cells, which are one-time use and irreversible, and secondary cells, which are rechargeable and reversible. Examples include dry cells and lead storage cells. The components and rea

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Blood is a complex tissue composed of red cells, white cells, platelets, and plasma, each serving crucial functions such as oxygen transport, waste removal, and immune system support. Red cells contain hemoglobin for oxygen transport, while white cells play a key role in defending the body against i

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Fuel cells are electrochemical cells that generate electricity through reactions between fuel and an oxidizing agent like oxygen. They offer high efficiency compared to traditional power plants. The working of fuel cells involves hydrogen and oxygen reacting to produce electricity. NASA has utilized

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Cr(VI)-induced mutagenesis is a key event in the mode of action for small intestinal tumors in mice, with the question of whether it is an essential step in tumor development. The interaction of cellular components with Cr leads to cell proliferation, hyperplasia, and ultimately mutagenesis. Differe

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