Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

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The ALIGN.AR trial evaluates Trilogy THV system in high-risk patients with severe aortic regurgitation. Untreated AR is linked to high mortality, emphasizing the need for safe alternative interventions like TAVR devices. The study aims to demonstrate safety and effectiveness of the Trilogy valve in

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Clinical Trial Management System (CTMS) Market by Component (Software, Service), Type (Enterprise, Site), Mode of Delivery (Web, Cloud, On-premise), End User (CRO, Pharmaceutical & Biotech, Medical Device Companies) - Global Forecast to 2030

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The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

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This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the

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Study on Zongertinib, a HER2 tyrosine kinase inhibitor, in patients with HER2 aberration-positive solid tumors. The trial involves multiple centers worldwide and aims to evaluate the efficacy of Zongertinib in treating various cancers harboring HER2 mutations. Financial disclosures of lead investiga

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This content provides detailed information on the divorce processes in Yavapai County Superior Court, including guides, services, and profiles of the presiding judges. It covers alternative dispute resolution services, legal counsel, and insights into the court's workings. The visual elements highli

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Cardiovascular disease is a growing concern in individuals living with HIV, despite advancements in treatment. The REPRIEVE Trial sheds light on the importance of assessing cardiovascular risk and implementing primary prevention measures in this population. Dr. Grinspoon's financial disclosures and

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The REPRIEVE trial focuses on developing a cardiovascular disease prevention strategy for individuals living with HIV. It addresses the increased risk of CVD in this population, even with good viral suppression. The study evaluates the use of pitavastatin, a statin with anti-inflammatory properties,

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This UK-wide clinical trial aims to assess the effectiveness of early peripheral norepinephrine infusion in adult patients with septic shock. The study will compare the impact on mortality and other outcomes of targeting a mean arterial pressure (MAP) above 65mmHg within the first 48 hours of admiss

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The PUSH-AHF trial, conducted at the University Medical Center Groningen, aimed to evaluate the effectiveness and safety of natriuresis-guided diuretic therapy in acute heart failure. The study design was pragmatic, prospective, single-center, open-label, randomized, and controlled. Key outcomes inc

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The CLEAR Outcomes Trial investigated the effects of bempedoic acid, an ATP citrate lyase inhibitor, on cardiovascular outcomes in primary prevention patients. Results showed a reduction in cardiovascular events with bempedoic acid, particularly in patients intolerant to statins. Baseline characteri

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This study details the principal results of the RELIEVE-HF trial, investigating the safety and effectiveness of the V-Wave Ventura interatrial shunt device in patients with heart failure with reduced and preserved ejection fraction. Key inclusion and exclusion criteria are outlined, emphasizing the

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Enhance your trial presentation skills with insights from Judge Renee A. Goble of Denver County Court. Learn about trial structure, direct and cross-examination techniques, understanding evidence, objections, and more to improve your courtroom performance.

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Dive into a comprehensive program focusing on DNA testing, pre-trial preparation, cross-examination, and expert testimony in legal proceedings. Explore the nuances of DNA limitations, problematic questions, and the intricacies of fingernail and ligature testimony. Gain insights on effective communic

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Preliminary principles and rules regarding hearsay in Virginia courts, including the effective date of the Virginia Rules of Evidence, application of rules in various trial scenarios, criteria for admissibility of evidence by trial judges, and reasons for the legal distrust of hearsay evidence. The

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The Juvenile Court Judges Commission in Pennsylvania, comprising nine judges appointed by the Governor, plays a crucial role in providing leadership, advice, and support to improve the state's juvenile justice system. Their mission is focused on community protection, offender accountability, victim

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Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

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In patients with acute myocardial infarction (AMI) and multivessel coronary artery disease, this study aims to compare fractional flow reserve (FFR)-guided PCI with angiography-guided PCI for non-infarct-related artery lesions. The hypothesis is that selective PCI guided by FFR is superior to routin

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Explore the process of simulating clinical trial designs, including traditional and adaptive approaches. Learn how to generate data, conduct analysis, make within-trial decisions, and summarize results using fixed-sample two-arm parallel group trials and group-sequential designs. Dive into methods l

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The UK Mini Mitral Trial compares the outcomes of minimally invasive thoracoscopic-guided right minithoracotomy versus conventional sternotomy for mitral valve repair. The trial aims to determine if physical function improvement post-surgery at 12 weeks is superior in the minimally invasive approach

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The significance of providing good character directions in legal proceedings has evolved over time, progressing from being discretionary to mandatory in certain situations. This presentation delves into the historical development of allowing evidence of good character, the definition of character in

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Pretrial motions in limine (MIL) play a crucial role in civil pretrial practice by seeking evidentiary rulings in advance to control the introduction of evidence at trial. These motions aim to prevent the admission of irrelevant, inadmissible, or prejudicial evidence and can also facilitate the intr

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Explore the various types of hearings available in the Court Management System, such as Motion Calendar, Special Sets, Calendar Call/Trial, Pre-Trial Conference, and Case Management. Learn how to set up new hearings/events and understand the process of generating trial orders and pre-trial conferenc

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The STRESS-L Trial focuses on reversing septic shock using Landiolol, a beta-blockade treatment. It provides training for non-GCP trained clinicians involved in eligibility review, medical care, and prescribing in the trial. The slides cover key GCP principles, trial agenda, study information, backg

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Comparative effectiveness study known as ESETT Trial aims to determine the most effective second-line agent for treating benzodiazepine-refractory status epilepticus in emergency departments. Fosphenytoin, valproic acid, and levetiracetam are common choices, but the best option remains uncertain. Th

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Dmitri Nepogodiev, a Clinical Lecturer in Public Health at the University of Birmingham, leads the DRAGON Trial aiming to compare the effectiveness and sustainability of reusable versus single-use drapes and gowns in surgical settings. With a focus on reducing surgical site infections, carbon footpr

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The CLEAR Trial is a 2x2 factorial randomized trial evaluating the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the trial focuses on clinical and c

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Judicial officers encounter difficulties in court and case management, including expeditious disposal, control over cases, discouraging wasteful pre-trial activities, and fixing schedules for applications, replies, and disposal. The process involves initial case management conferences, timely comple

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ACST-2 is a randomized trial comparing carotid artery stenting (CAS) versus carotid artery surgery (CEA) in asymptomatic patients with severe carotid stenosis. The trial, published in The Lancet in August 2021, involved 3625 patients. While surgery has been shown to reduce stroke rates, modern medic

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The Sixth Amendment guarantees various rights during criminal trials, such as a speedy and public trial, trial by jury, notice of accusations, the right to confront witnesses, and the assistance of counsel. Defendants can opt for a bench trial where the judge decides innocence or guilt. Juries, typi

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This training guide provides essential information for judges in cheer and dance competitions, covering topics such as professionalism, accountability, recognizing difficulty, and competition divisions. It emphasizes the basic responsibilities of a routine judge, professionalism expectations, scorin

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The DAPA-HF trial investigated the use of dapagliflozin, an SGLT2 inhibitor, in patients with heart failure and reduced ejection fraction, regardless of diabetes status. Funded by AstraZeneca, the study enrolled 4,744 patients from 20 countries, showing promising results in reducing cardiovascular d

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Prepare yourself with this comprehensive guide for FFA judges on parliamentary procedure. Learn about the major changes in guidelines for the Career Development Event, room set-up instructions, changes to the Opening Ceremonies, and how to use the Subject/Ability Sheets effectively. This guide break

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Judges 19 narrates a story of contrasts and reconciliation involving a Levite and his concubine. The narrative showcases a conscious contrast to the preceding story, highlighting the Levite's journey to recover his concubine from the south. As the story unfolds, themes of patience, respect, and posi

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Adaptable and open clinical trial infrastructure emphasizing collaborative leadership with shared responsibilities for successful trial implementation and data integrity. Encourages respectful ownership by investigators while engaging with NIH and SIREN to develop and fund important trials, includin

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The CLEAR Trial is a 2x2 factorial randomized trial examining the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the study focuses on exacerbation ma

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Explore the top 10 trial traps, tricks, and techniques presented by Judge Joyce Draganchuk from Ingham County Circuit Court. Learn about self-representation requirements, managing disruptive defendants, challenges in jury selection, and more essential insights for a successful trial practice.

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NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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Development of case report form worksheets for data collection in a randomized trial focusing on enteral glutamine use to minimize thermal injury. The document provides detailed instructions for research coordinators on data recording from medical charts to be entered into the electronic data captur

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