HER2 activation plays a crucial role in promoting tumor proliferation and survival in NSCLC. Driven by oncogenic downstream signaling pathways, HER2 overexpression and gene amplification lead to the formation of heterodimers and activation of key signaling cascades. Additionally, HER2 mutations are

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Families often come into contact with children's social care due to parenting under adversarial conditions rather than causing harm. The need for a change in vision and values underpinning family safeguarding duties is crucial, emphasizing the importance of helping families raise their children. Lad

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The PROTEOCURE COST Action focuses on targeting proteolysis for proteome remodeling, aiming to enhance Europe's scientific and technological capacity through collaboration across various fields and career stages. Participating in this initiative offers financial support, scientific networking, and c

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Praise plays a crucial role in promoting children’s self-esteem and overall development. By offering genuine praise for being and doing, parents can nurture a positive sense of self-worth in their children. Research shows that praised children tend to excel academically, show resilience, and lead

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Explore the potential of targeting human exosomes using a bispecific antibody platform, enhancing drug delivery capabilities. The study delves into engineering exosomes as drug carriers, developing exosome targeting antibodies (ExTAbs), and verifying exosome delivery efficiency. Future directions in

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The public hearing on the regulation of political advertising delves into categorizing personal data, different data types, processing techniques, and associated risks like undermining autonomy and democratic processes. Stakeholders emphasize the need for transparency in targeting and delivery of ad

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Thematic Working Group for Libya Flood Responses held a meeting on 17 October 2023 to discuss coordinated responses, targeting needs and damage assessments. Updates and documents published by partners after 10 October 2023 were shared, including reports from SRSG Abdoulaye Bathily and various agenci

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In the dynamic landscape of cargo services, effective market segmentation and targeting are crucial for maximizing profitability and operational efficiency. Revenue Technology Services s(RTS) plays a pivotal role in advising cargo companies on crafting robust strategies tailored to diverse customer

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The briefing highlights concerning findings from the inspection of Herefordshire children's services, revealing significant weaknesses in social work practice, poor assessments, and insufficient plans to ensure children's safety and well-being. The report identifies systemic issues such as drift, de

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The Child Care and Protection Act of 2015, Chapter 20, addresses harmful social, cultural, and religious practices affecting children in Namibia. The Act prohibits practices detrimental to children's well-being, such as child marriage, and imposes penalties on those who subject children to such prac

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The Government of Liberia's COVID-19 Household Food Support Programme aims to assist those facing food insecurity in four target counties. Using data from various assessments, the programme estimates a caseload of 1,971,000 individuals. Targeting strategies include geographical and household-level c

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The Citizen Security and Justice Programme (CSJP) under the Ministry of National Security in Jamaica focuses on violence prevention through case management, risk assessment, and treatment plans. By targeting at-risk youth and implementing services such as education, psychological support, and peer a

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Children and young people up to 18 years are entitled to rights under the United Nations Convention of the Rights of the Child (UNCRC). This agreement aims to protect children and ensure they are happy, healthy, and safe. It covers topics such as the role of the Children's Commissioner for Wales, Sa

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Uganda has successfully implemented an Assisted Partner Notification (APN) program to reach men for HIV testing, addressing the gender gap in testing rates. By utilizing various approaches such as index testing, self-testing, and social network testing, Uganda has achieved significant success in tar

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The National Shelter and Non-Food Items Cluster meeting in Iraq on Wednesday, 24th September 2014 discussed various important agenda items including updates on the SRP process, strategic objectives, overview of cluster projects, types of assistance provided, and targeting vulnerable groups. A total

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This seminar focuses on common scams targeting Licensed Professional Counselors, including phishing, Canadian, limo driver, and sheriff scams, social media scams, and fake tech support. Presented by industry experts, it provides insights on recognizing red flags, avoiding scams, and steps to take if

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Children are considered vulnerable consumers due to undeveloped executive functions like inhibitory control and cognitive flexibility. They struggle to differentiate between commercials and TV programs, making them susceptible to marketing strategies targeting them with food/beverage products. Marke

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This research roundtable delves into the impact of food advertising and marketing on children and youths as part of the Bridging the Gap program. The collaborative effort assesses various health-related behaviors influenced by policies, programs, and environmental factors, including adolescent eatin

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Children living with parental alcohol problems often face challenges that can have lasting effects on their well-being. This seminar highlights the need for support and courage for these children and discusses the implications for practitioners. It also sheds light on the hidden population of childr

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Healthy Eating Research Program, launched in 2005, focuses on preventing childhood obesity by targeting children, adolescents, and families. The program aims to establish a research base on factors influencing healthy eating and body weight in children, build a multidisciplinary research field, and

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The World Bank and UNHCR collaborate to enhance the effectiveness of assisting Syrian refugees by leveraging survey data to optimize targeting strategies for cash assistance programs. By combining registry and survey information, the study aims to identify the best welfare and poverty indicators, ul

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IFAD independent evaluations play a crucial role in ensuring that vulnerable groups are not left behind in rural development initiatives. By assessing the effectiveness of targeting methods, documenting instances where vulnerable groups are excluded, and providing recommendations for improvement, th

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Inflation targeting emphasizes clear communication with the public and financial markets, enhancing transparency and accountability in monetary policy. By setting explicit inflation targets, central banks improve public understanding, encourage debate, and increase the accountability of policy-maker

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Explore the fundamentals of direct work with children and young people in the Newham Children Services Practitioners Workshop 2020. Discover the purpose, planning, and application of direct work, focusing on outcomes and challenges. Learn to apply a systemic and restorative approach, utilizing solut

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Established in 2007, the CDI focuses on prevention and early intervention through a range of programs targeting children and families. Interventions include early years support, literacy programs, and community initiatives. The commissioning process involves independent evaluations, and randomized c

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Market segmentation involves dividing a market based on distinct needs or characteristics for tailored marketing strategies, while targeting is the process of selecting attractive segments to serve. This process helps in designing a customer-driven marketing strategy by identifying specific customer

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In today's society, children are constantly exposed to advertising through various media channels, influencing their perceptions and behaviors. This research delves into how children perceive and interact with advertisements, highlighting the importance of understanding the persuasive intent and pot

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The Australian social security system provides flat-rate entitlements from general government revenue to ensure a minimum level of income support. Various benefits cater to different eligibility criteria and activity requirements, including support for children and child care costs. The system is ef

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The Children and Youth Cabinet in Florida adopted six key measures as benchmarks in 2017. These indicators cover areas such as low birthweight babies, children not in school readiness programs, children living in poverty, infants and toddlers without health insurance, and children under 12 at first

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Explore the potential of targeting the by-owner market, specifically Self-Managing Investment Property Owners (SMIPOs), as a blue ocean strategy for property management companies. This approach involves addressing key questions on adding more doors, effective marketing allocation, profitable market

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Explore the pricing details for displaying products in 2023, including rich media fees, targeting options, and digital edition full page ads. Learn about different ad formats, targeting pricing levels, and rich media ad formats. Discover how to reach tailored audiences and utilize various targeting

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Explore how the Family and Children's Trust Fund (FACT) in Virginia supports the prevention and treatment of family violence through data management and strategic goals. Learn about managing by data, FACT's initiatives, and the significance of prevention in addressing family violence issues.

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Explore the birth of modern children's literature starting with the publication of "Alice's Adventures in Wonderland" in 1865 by Charles Dodgson (Lewis Carrol), marking a shift towards entertaining and engaging literature specifically for children. Prior to this, children mainly read folklore and ad

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Five years on from the UK National Year of Reading, efforts continue to address literacy issues, particularly targeting disadvantaged groups such as early years, boys, teenagers, minority ethnic communities, and disabled children. Initiatives include research, messaging, and partnerships to improve

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Weight training, a fundamental method for enhancing strength and overall physical fitness, involves various exercises like isotonic, isometric, and isokinetic movements utilizing equipment such as barbells, dumbbells, and machines. Incorporating a variety of exercises targeting different muscle grou

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The study aims to determine the prevalence of amblyopia and its risk factors among school children in rural areas of Telangana using spot vision screener. A sample of 369 children aged 5-10 years was screened, with 84 children showing amblyogenic risk factors. Out of these, 65 children were diagnose

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Dr. Aleu Pioth Akot led the successful Seasonal Malaria Chemoprevention (SMC) campaign in Northern Bahr el Ghazal State, South Sudan in 2023. The focus was on reducing malaria morbidity and mortality among high-risk children aged 3-59 months. Key lessons learned included implementing a door-to-door

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Children are vulnerable to exploitation, abuse, and neglect due to various factors such as age, disabilities, behaviors, and powerlessness. The vulnerability of children is compounded by factors like illness, defenselessness, and passivity. Categories such as protection and children in conflict with

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Trauma can significantly affect children's emotional, behavioral, and developmental well-being. Research shows that a high number of children experience traumatic events, leading to various challenges. Younger children are particularly vulnerable to the effects of trauma, depending on how their pare

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This document outlines the detailed design and safety considerations for a rocket targeting a specific altitude. It covers materials used, rocket components and dimensions, motor selection and simulation, recovery system details, and electronic recovery mechanisms. Emphasis is placed on compliance w

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