Blood transfusion is a crucial medical procedure worldwide, with various components like packed red blood cells, plasma, platelets, and cryoprecipitate being utilized for efficient use. Differential centrifugation is employed for component preparation, ensuring precise separation of red blood cells,

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Pathogen-reduced platelets play a crucial role in reducing the risk of transfusion-transmitted infections through pathogen inactivation technology (PIT). This technology provides an additional layer of safety against various pathogens including viruses, bacteria, protozoa, and leukocytes. Platelet c

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This update covers the latest developments in pathogen reduction of platelets, including the introduction of whole blood containing platelets. Key strategic initiatives focus on assessing post-collection blood product manipulation processes and developing new products to meet healthcare needs. The a

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Immune Thrombocytopenia (ITP) is a rare autoimmune disease where the immune system wrongly attacks platelets, leading to low platelet count. It can affect individuals of all ages, with symptoms appearing post-virus, vaccination, or certain medications. ITP can result in fatigue, bruising, and bleedi

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Hematopoiesis, the process of daily blood cell production, involves maintaining the physiological balance of circulating blood cells. It includes the generation of billions of erythrocytes, platelets, and leukocytes to meet the body's needs. The location of hematopoiesis changes throughout human lif

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The Bleeding Time (BT) test evaluates platelet plug formation and capillary integrity, crucial for surgery preparations. Prolonged bleeding times indicate low platelet count or dysfunction. The Duke method is one way to determine Bleeding Time. Sources of error, such as medication interference, impr

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Blood clotting factors play a crucial role in the coagulation process to prevent excessive bleeding. Factors such as Fibrinogen (Factor-I), Prothrombin (Factor-II), Thromboplastin (Factor-III), Calcium Ions (Factor-IV), Labile Factor (Factor-V), and Stable Factor (Factor-VII) are essential for the c

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Coagulation profile testing is crucial in assessing blood clotting ability. The process of coagulation is essential for hemostasis to prevent bleeding or clotting disorders. This summary explores the steps involved in hemostasis, the clotting cascade, and the triggers for the extrinsic and intrinsic

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Chronic myeloid leukemia (CML), or chronic myelogenous leukemia, is a slow-growing form of cancer that affects the bone marrow and blood. Like acute myeloid leukemia, CML originates in the myeloid cells. When functioning properly, myeloid cells produce mature red blood cells, platelets and non-lymph

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Efficacy and Dosage Efficacy & Dosage Efficacy of Anagrelide (0.5mg) What is Anagrelide? Essential thrombocythaemia is a condition in which an excessive amount of platelets are present in the blood. Anagrelide 0.5 mg inhibits the production of platelets, thereby reducing the risk of blood clotting,

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Explore the types and dietary sources of vitamin K, including Phylloquinone and Menaquinone. Discover the essential role of vitamin K as a coenzyme in the synthesis of prothrombin and blood clotting factors such as II, VII, IX, and X through carboxylation. Learn about the recommended daily allowance

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This informative material delves into the significance of determining blood groups, clotting time, and bleeding time in medical settings. From explaining the ABO and Rhesus systems to outlining the practical objectives and procedures for the assessments, this resource aims to enhance understanding o

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Chemical mediators of inflammation act on blood vessels and cells to contribute to an inflammatory response. These mediators include vasoactive amines like histamine and serotonin, plasma proteases such as the complement, kinin, and clotting systems, and important inflammatory mediators like C3a and

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Your blood, consisting of red blood cells, white blood cells, platelets, and plasma, plays a crucial role in transporting substances like oxygen, nutrients, and waste products throughout your body. Red blood cells are specialized for oxygen transport due to their unique adaptations, while white bloo

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Hemostasis refers to the prevention of blood loss through vascular constriction, platelet plug formation, blood clotting, and fibrous tissue growth. Vascular constriction occurs immediately after vessel damage, initiated by myogenic spasm, autacoid factors, and nervous reflexes. Platelet plug format

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Hemostasis, crucial for preventing blood loss, involves platelet formation, clotting factors, and fibrinolysis. This process includes vessel constriction, platelet activation, clot formation, and fibrin breakdown. Platelets, produced in the bone marrow, play a vital role in maintaining vascular inte

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Coagulation is a crucial process in hemostasis that involves clot formation. This profile delves into estimating clotting time, bleeding time, and prothrombin time to assess coagulation status. Explore the mechanisms of hemostasis, clotting cascade, triggers of intrinsic and extrinsic pathways, and

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Platelets, also known as thrombocytes, play a crucial role in blood clotting. This article explains the structure and lifespan of platelets, the purpose of performing a total platelet count, and the principle of counting platelets using a hemocytometer. It also describes the components used for plat

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Inflammatory diseases of bone encompass conditions like osteitis, osteomyelitis, periostitis, and alveolar osteitis (dry socket). Osteitis is localized and may be associated with infected sockets, while osteomyelitis involves the interior of the bone. Alveolar osteitis commonly follows tooth extract

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Anticoagulants are crucial additives that prevent blood clotting during laboratory procedures. The commonly used anticoagulants include EDTA, sodium citrate, and heparin, each with specific concentrations, modes of action, and color-coded identifications. EDTA is ideal for blood cell counts, sodium

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Anticoagulants play a crucial role in hematology by preventing blood clotting, allowing separation of blood components, with EDTA being the most commonly used anticoagulant. Proper blood-to-anticoagulant ratio is essential to avoid inaccuracies in results, such as falsely reduced hematocrit or erron

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Veterinary physiology involves studying the functions of intact organisms, organs, tissues, and systems. Blood, consisting of plasma and formed elements, plays vital roles in nutrient transport, gas exchange, waste removal, hormone distribution, temperature regulation, water balance, pH maintenance,

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Delve into a comprehensive overview of the liver's anatomy, including ligaments, blood supply, and structure in the hilum. Explore the vital functions performed by the liver, such as maintaining body temperature, synthesizing clotting factors, and drug metabolism. Discover liver function tests and t

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Vitamin K deficiency in animals can lead to serious health issues due to its crucial role in blood clotting and bone metabolism. Different sources of vitamin K, such as plant material and bacterial fermentation, provide essential forms like K1 and K2. Factors contributing to deficiency include fat m

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This comprehensive guide covers various types of cardiac medications including anticoagulants, antiplatelet drugs, thrombolytics, and beta-blockers. It details their mechanisms of action, dosage guidelines, side effects, and contraindications. Anticoagulants prevent blood clotting, antiplatelets inh

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Analysis of data from January to June 2020 at the Aintree Dialysis Unit under the KQUIP Magic Project reveals issues with needle clotting and flow disruptions. Lessons learned include priming needles with saline and seeking help when needed. Efforts to sustain the project involve staff education, pa

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Platelets play a crucial role in hemostasis and bleeding disorders. This lecture by Dr. Mohammed Alotaibi covers the ultrastructure of platelets, functions of organelles and surface receptors, mechanisms of platelet functions, and the relationship of membrane receptors and granule content in normal

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The Oxford-AstraZeneca vaccine has shown a likely but unproven link to cerebral venous sinus thrombus and other blood clotting issues. Despite this, the benefits of vaccination still outweigh the risks, with only approximately 4 cases per million resulting in death. Communication of the potential be

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Snake bite management involves reassuring the victim, immobilizing the affected limb, and promptly transporting the individual to a hospital with snakebite treatment facilities. Local and systemic examinations are essential to assess the severity of envenomation, followed by necessary investigations

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Antiphospholipid antibody syndrome is an acquired disorder characterized by recurrent thrombosis or pregnancy complications due to autoantibodies against phospholipid-binding plasma proteins. Learn about its classification, epidemiology, pathogenesis, and diagnostic antibodies. Discover how lupus an

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Blood, a vital fluid tissue in the cardiovascular system, plays crucial roles in transportation, regulation, and protection. Comprised of cellular and non-cellular components suspended in plasma, it facilitates the transport of gases, nutrients, hormones, and waste products, regulates temperature, p

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Dairy products are essential for providing nutrients like calcium, vitamin D, and protein. They help in bone and muscle health, blood clotting, and nerve function. If you are lactose intolerant, there are alternative sources to get calcium. Meeting the recommended daily allowance of calcium is cruci

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Anticoagulants play a crucial role in preventing blood clotting and are used in various medical conditions such as myocardial infarction and deep venous thrombosis. They include heparin, warfarin, and antiplatelet agents like aspirin. This article explores the mechanisms of action, indications, and

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Clinical chemistry specimen collection involves obtaining blood samples for analysis. Serum and plasma are commonly used specimens, each requiring specific handling. Different anticoagulants like heparin are used to prevent blood clotting during sample processing. Heparin, a widely used anticoagulan

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Calcium homeostasis plays a crucial role in various physiological functions, including bone integrity, blood clotting, enzymatic regulation, hormonal secretion, neurotransmitter release, nerve excitability, and muscle contraction. Bones act as a major calcium reservoir, with blood containing 50% ion

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The clotting cascade is a complex process involving intrinsic and extrinsic pathways that converge to form fibrin, leading to clot formation. Hemostasis is initiated mainly through the extrinsic pathway in vivo, activating factors that generate thrombin and ultimately convert fibrinogen into insolub

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Blood is a complex fluid composed of various components like platelets, erythrocytes, and leukocytes suspended in plasma. Microhaematocrit is a technique used to measure hematocrit levels in blood. The process involves collecting blood in a capillary tube, centrifuging it to separate the layers, and

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Blood, a vital fluid tissue in the cardiovascular system, plays essential roles in transportation, regulation, and protection within the body. This includes carrying gases, nutrients, hormones, and waste products, regulating temperature, pH, electrolytes, and blood pressure, as well as providing def

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Blood is a vital fluid tissue in the human body, classified as a connective tissue. It consists of living cells known as formed elements suspended in a non-living matrix called plasma. The physical characteristics of blood, such as color range, pH level, and temperature, play crucial roles in mainta

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Explore the intricate details of blood, the river of life, including its components such as formed elements, plasma, leukocytes, platelets, and the process of hematopoiesis. Learn about the physical traits of blood, the role of proteins in plasma, types of leukocytes, and the importance of platelets

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