Iron deficiency is prevalent in heart failure patients with reduced ejection fraction and is linked to poor outcomes. The HEART-FID trial investigates the impact of intravenous ferric carboxymaltose (FCM) on all-cause mortality, heart failure hospitalizations, and exercise capacity in chronic HFrEF

1 views • 17 slides

SISTER Study led by Eva Mistry aims to identify a safe and effective dose of TS23 for treating ischemic stroke patients with core-penumbra mismatch. The Phase-2 trial involves 300 adults and spans 54 months, with primary endpoints focusing on treatment efficacy and safety. The study is randomized, p

0 views • 22 slides

Acoramidis, a next-generation TTR stabilizer, shows promising results in improving cardiac function and promoting regression in Transthyretin Amyloid Cardiomyopathy. The ATTRibute-CM Cardiac Magnetic Resonance Substudy evaluated changes in cardiac structure, function, and amyloid burden after treatm

0 views • 8 slides

Research ethics play a crucial role in clinical trials and therapeutic research in the field of pharmacy. From discovery to validation, all medicines undergo rigorous evaluation processes to ensure safety, efficacy, and freedom from adverse effects. Clinical trials in both animals and humans are ess

0 views • 20 slides

Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

2 views • 22 slides

Evidence suggests that psychotherapy works for many individuals, with high satisfaction rates reported. Critics, however, raise concerns about placebo effects, therapist biases, and human biases influencing perceptions of success. Clinicians acknowledge successful cases but remain cautious of cognit

0 views • 36 slides

The ATLANTIS study evaluated the efficacy of low-dose amitriptyline (10-30 mg) in improving Irritable Bowel Syndrome (IBS) symptoms compared to placebo in a 6-month randomized controlled trial in a primary care setting. This important research aims to address the lack of definitive treatment guideli

0 views • 12 slides

HPTN 069/ACTG A5305 is a Phase II study evaluating the safety and tolerability of Maraviroc (MVC)-containing regimens compared to Tenofovir/emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP) in at-risk women. The study involves a randomized, double-blind, placebo-controlled design with

0 views • 18 slides

Subgroup analysis from the iPrEx trial and open-label extension assessed the efficacy, drug concentrations, and adherence of TDF-FTC PrEP for transgender women assigned male at birth. Results indicate varying drug detection consistency and non-condom receptive anal intercourse among participants.

1 views • 7 slides

This Phase 2 clinical trial compares the efficacy of NGM282 (3 mg vs 6 mg) versus placebo in patients with NASH. The primary endpoint is a 5% reduction in liver fat content at 12 weeks. Randomisation was stratified by diabetes status, and stable Type 2 diabetes and lipid-lowering treatments were mai

0 views • 6 slides

ASPIRE Training focuses on randomization and initial dispensing of prescriptions for the MTN-020 study. It involves assigning prescriptions in sequential randomization order, tracking prescription assignments, and completing two-part NCR prescription forms. Each prescription has a unique randomizati

0 views • 25 slides

The Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm (ASCOT-LLA) conducted on hypertensive patients investigated the impact of atorvastatin versus placebo on cardiac outcomes. The study revealed a significant reduction in nonfatal myocardial infarction and fatal coronary heart disease wi

0 views • 20 slides

Dr. Sarah Murray leads the STOPPIT-3 study, assessing the use of antenatal corticosteroids in twins for planned births to reduce respiratory morbidity. The trial aims to address the lack of evidence in this area, with potential benefits in reducing neonatal unit admissions but also risks such as neo

0 views • 14 slides

This content provides an overview of clinical trials, including the goals, phases, study funding, and important terms such as placebo. Clinical trials aim to study the impacts of health and disease, evaluate treatments, and ensure safety and effectiveness. The phases of clinical trials are explained

0 views • 27 slides

The ATLAS-ACS 2 study investigated the efficacy and safety of rivaroxaban in ACS patients post-index event. The primary endpoints included cardiovascular death, MI, and stroke, with significant reductions seen with rivaroxaban compared to placebo. Stent thrombosis was also reduced with rivaroxaban t

0 views • 10 slides

This module provides an overview of the STRATA Carer Study, which aims to explore how treating anxiety in adults with autism influences the burden on their carers. The nested study runs parallel to the main STRATA trial and involves assessing carer burden over a 52-week treatment period with sertral

0 views • 16 slides

This study evaluates 15 treatment outcome measures for cocaine use across multiple randomized controlled trials from 2000 to present. The criteria include sensitivity to medication and behavioral therapies, post-treatment cocaine use, and general functioning. Various studies focus on treatments such

0 views • 20 slides

Renal function in the PROUD study, a pragmatic open-label randomized trial of Truvada as pre-exposure prophylaxis, was monitored closely. No significant safety concerns were found, with similar renal adverse events between the placebo and Truvada groups. Regular monitoring included baseline serum cr

0 views • 16 slides

Explore key definitions and concepts related to statistical studies, including terms such as census, cluster sampling, experimental study, histogram, placebo effect, questionnaire, secondary research, simple random sampling, statistical bias, and more. Gain insights into the vocabulary and principle

0 views • 18 slides

Crisaborole ointment, a nonsteroidal PDE4 inhibitor, demonstrated efficacy and safety in the treatment of atopic dermatitis in patients aged 2 years and older. Results from two phase 3 studies showed a significant improvement in disease severity with crisaborole compared to the vehicle. Treatment-re

0 views • 23 slides

The study investigates the impact of sleep deprivation and stimulant types on motor task performance in a driving simulation game. Factors such as sleep deprivation methods (control, jet lag, interrupted, total deprivation) and stimulant types (placebo, caffeine, reward) are analyzed through a two-w

1 views • 10 slides

Over-the-counter artificial tear drops are commonly used as a first-line treatment for dry eye syndrome. This study evaluated the effectiveness and toxicity of OTC artificial tears compared to other classes of OTC artificial tears, placebo, or no treatment. Results showed no significant difference i

0 views • 13 slides

The ASPIRE trial evaluated simeprevir treatment in patients with treatment-experienced chronic HCV genotype 1 infection. The study design included different dosing regimens of simeprevir with peginterferon and ribavirin, compared to placebo. Results showed varying sustained virologic response rates

0 views • 9 slides

Permutation tests are computer-intensive methods used for hypothesis testing when the distribution of the test statistic is unknown. In a hypothetical HPV vaccine trial with 200 women, the scientific question revolves around comparing infection risks in groups receiving the vaccine and placebo. The

0 views • 19 slides

Patients with COVID-19 are at higher risk of thrombotic events, and antithrombotic regimens have shown varied results in previous trials. The APOLLO trial investigated the use of apixaban for prophylaxis in outpatients with additional risk factors. Results indicated that low-dose apixaban did not si

0 views • 18 slides