Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

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The submission discusses the application of Next-Generation Optical Camera Communication (NG-OCC) in virtual power plants, highlighting its advantages in transmitting data efficiently and reliably in the energy sector. NG-OCC utilizes light for communication, minimizing interference risks and offeri

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Technocrats Institute of Technology (Excellence) in Bhopal delves into the concepts of signal degradation in optical fiber communication, focusing on attenuation, distortion mechanisms, and measurement techniques. The institute emphasizes the importance of signal attenuation and its impact on inform

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This presentation by Professor Don Figer explores modern optical and infrared instrumentation used in astronomy, including cameras, spectrographs, and specialized devices like coronagraphs. It covers instruments such as HST, Spitzer, Chandra, JWST, ELTs, and WFIRST, highlighting their capabilities i

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This document discusses the proposal to incorporate optical bands into the channelization framework of the IEEE 802.11 standard. It aims to align the channelization approach for integrated LC with that of mm-wave technology in the IMMW scope. The contribution highlights recent works, emphasizing the

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Depending on the type of laser, various pumping methods are used including optical pumping, electric discharge pumping, chemical pumping, and heat pumping. Optical pumping utilizes light energy to achieve population inversion in the laser medium, while electric discharge pumping involves passing hig

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Chromosomal aberrations involve significant changes in chromosome structure and number, impacting multiple genes. These mutations can be structural or numerical, resulting in alterations such as deletions, duplications, inversions, and translocations. Deletions, for example, involve missing chromoso

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Optical Coating Market By Product (Anti-Reflective Coatings, High Reflective Coatings, Transparent Conductive Coatings, Filter Coatings, Beam Splitter Coatings, Others), By Technology (Vacuum Deposition, E-beam Evaporation, Sputtering Process, Ion-As

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Genetic mutations can be harmless, harmful, or beneficial, leading to variations within a species. Examples of gene mutations and chromosomal aberrations, like Trisomy 21, illustrate genetic abnormalities. The increase in Down Syndrome cases with maternal age highlights a maternal age effect. Geneti

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Discrete auto analyzers integrate specimen handling, reagent systems, optical components, and computers for streamlined functionality. The innovation in computer technology, particularly microprocessors, has revolutionized these analyzers, enabling precise data management, liquid handling, and optic

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Microscopy plays a crucial role in examining the structural elements and defects influencing material properties. This involves studying microscopic features like grain size and shape using optical, electron, and scanning probe microscopes. Microstructural examinations help understand property-struc

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Circular dichroism and optical rotatory dispersion are important techniques for studying the optical properties of optically active compounds. Circular dichroism measures the differential absorption of left and right circularly polarized light components, while optical rotatory dispersion studies th

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Optical telescopes utilize lenses or mirrors to collect and focus light for imaging celestial objects. The lens-maker's formula is crucial for determining the focal length of lenses, considering factors like index of refraction and radii of curvature. Different lens configurations and materials help

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Optical fibre technology, spearheaded by Dr. Prabodh Sahai Saxena, revolutionizes communication systems through light transmission. This cutting-edge technology utilizes fibre optics made of glass or plastic to carry light signals, offering advantages like high bandwidth, low signal loss, and no ele

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The journey of optical technology evolution spans from the invention of the telegraph in 1836, through the introduction of optical fibers in 1978, to the development of photonic integrated circuits in the present era. Key milestones include the advent of optical amplifiers in 1990, the emergence of

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A case report explores the use of optical genome mapping (OGM) to unravel a complex KMT2A rearrangement in an AML patient. Traditional cytogenetic analyses identified translocations and rearrangements involving chromosomes 10 and 11, leading to the fusion of genes KMT2A and MLLT10. OGM technique, ut

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Introducing a design concept for Optical Wireless Communication Link for Vehicular Assistant Technology (VAT), enabling V2V communication between living vehicles and other on-road vehicles. Utilizing back lights of living vehicles, this system aims to improve visibility and safety on the road, espec

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This article presents a detailed explanation of a point-to-point fiber optic communication system, outlining the process from voice conversion to signal transmission and reception. It discusses the advantages and limitations of optical communication systems, along with numerical examples related to

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This document provides an in-depth review of the safety considerations for the ATST optical equipment, focusing on potential hazards associated with the M2 Mirror, Heat Stop Assembly, and other critical components. The Preliminary Hazard Analysis identifies various risks, causes, and recommended act

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Institute of Laser for Postgraduate Studies at the University of Baghdad, led by Assist. Prof. Dr. Lutfi Ghulam Awazli, focuses on laser delivery systems in surgical procedures. The systems discussed include optical fibers, articulated arms, hollow waveguides, and free beams. Optical fibers, compose

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Optical storage technology originally designed for audio offers a capacity of 650MB, providing over 70 minutes of audio playback. Data is recorded digitally on a polycarbonate disk's surface as microscopic pits. The disk is organized in a spiral track with sectors of the same length arranged in bloc

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This content discusses the latest advancements in optical bench technology for gravitational wave detectors, focusing on precise measurements of back-scattered light, development of new optical cavities, and testing of Sagnac interferometers. Key objectives include improving suspension controls, red

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This presentation delves into the intricate process of optical alignment using a beam triangle, focusing on defining optical and mechanical axes, addressing alignment challenges, degrees of freedom for various elements, and the importance of setting up a beam triangle for accurate alignment. The con

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This research by Joseph Chong at Virginia Tech delves into the use of transimpedance amplifiers (TIAs) in CMOS technology for optical communications operating at a data rate of 40 Gb/s. The study outlines the motivation behind the project, the role of TIAs in optical receivers, TIA circuit topologie

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Regular examination and proper cleaning of tonometer prisms are essential to reduce the risk of transmitting infections during eye examinations. Disinfection and sterilization processes are crucial in maintaining optical equipment hygiene. Different disinfectants and physical methods can be used to

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Numerical chromosome aberrations involve the gain or loss of whole chromosomes, impacting the genome size and potentially leading to genetic mutations. Nondisjunction, where chromosomes fail to separate properly during cell division, can result in aneuploidy - the presence of an extra or missing chr

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Chromosomal aberrations and mutations are key events that can alter the genetic structure of organisms. They can lead to numerical abnormalities like aneuploidy and structural abnormalities such as ring chromosomes and chromosome fragments. Understanding these variations in chromosomes is crucial in

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Chromosome aberrations are deviations from the normal set of chromosomes, which can involve changes in chromosome number, gene arrangement, and appearance. These aberrations can be associated with genetic diseases and species differences. They encompass alterations in the number of genes within a ch

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Detailed examination of the optical setup for an Optical Frequency Interferometer (OFI) system, including the input/output configurations with various optical components such as prisms, crystals, and wave plates. The analysis focuses on the path and behavior of beams within the system, considering r

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Optical fiber technology has a rich history starting from John Tyndall's demonstrations in 1870 to the development of flexible fiberscopes by Hopkins and Kapany. This technology revolutionized communication systems and medical diagnostics, enabling the transmission of information through thin glass

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Understanding the principles and conditions governing optical image formation, including the role of broad bundles of rays, wave surfaces, magnification ratios, and axially-symmetric optical systems. Explore the conditions for imaging line segments, optical path lengths, and the general criteria for

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Detailed procedures for optical testing setups involving vacuum windows, polarizers, rotation stages, translation stages, photodiodes, scopes, power meters, and more. The process includes preparing the initial state, rotating analyzers, monitoring transmission, and verifying the direction and magnit

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Plastic injection molding is a cost-effective method for mass-producing optical components, offering an economical alternative to glass. This process involves designing molds, considering factors like shrinkage and surface equations, ensuring smooth mold flow, and regulating fluid flow through gates

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Introduction to an optical fiber calibration system and adaptive power supply developed by J. Cvach from the Institute of Physics, ASCR, Prague. The system includes an LED driver, notched fibers, and adaptive power supply for various applications, such as the calibration of the CALICE AHCAL and LHCb

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Centering optical elements and systems accurately is crucial for optical alignment processes. This lab focuses on using an air bearing rotary table and dial indicators to achieve precise centering. The equipment used includes PSM, displacement indicators, adjustment screws, and magnetic mounts. Prop

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Lens defects and aberrations in optics, such as chromatic and spherical aberrations, are caused by the laws of reflection and refraction. They lead to issues like longitudinal and lateral chromatic aberration, as well as spherical aberration. Proper correction methods, like using achromats with yell

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Discover how combinations of lenses form images, explore thin lens equations and magnification principles, learn about compound microscopes, and understand the limits to resolution including spherical and chromatic aberrations and dispersion effects in this informative lecture on optical instruments

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This lecture delves into the requirements for resolution and sensitivity in astronomical imaging, exploring factors such as spatial resolution, optical design aberrations, and noise sources. It explains how spatial resolution is crucial in distinguishing objects, discussing the Rayleigh criterion an

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Exploring the complexities of nonlinear optics in the perturbative and non-perturbative regimes, this research delves into the generation of harmonics, optical Kerr effects, and extreme nonlinear optical phenomena utilizing phase-controlled electromagnetic pulses. The work also investigates the inte

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ISO 10110 Optical Drawing Standards provide guidelines for preparing drawings of optical elements and systems, essential for interpreting optical drawings accurately. The standard includes 13 parts covering aspects such as material imperfections, surface form tolerances, and more. Compliance with IS

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