Understand the correlation between lipoprotein metabolism imbalance and the development of atherosclerosis. Learn about LDL and HDL cholesterol metabolism, receptor-mediated endocytosis, and the role of lipoprotein(a).

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This study explores how inflammation and cholesterol levels predict cardiovascular events among 13,970 statin-intolerant patients in the CLEAR Outcomes trial. Findings suggest residual inflammatory risk may be a stronger predictor than residual cholesterol risk for future events. The research analyz

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The REPRIEVE trial focuses on developing a cardiovascular disease prevention strategy for individuals living with HIV. It addresses the increased risk of CVD in this population, even with good viral suppression. The study evaluates the use of pitavastatin, a statin with anti-inflammatory properties,

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The CLEAR Outcomes Trial investigated the effects of bempedoic acid, an ATP citrate lyase inhibitor, on cardiovascular outcomes in primary prevention patients. Results showed a reduction in cardiovascular events with bempedoic acid, particularly in patients intolerant to statins. Baseline characteri

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The impact of diet on the cardiovascular system is significant, with a high intake of LDL leading to clogged arteries and increased risk of Coronary Heart Disease. Regular exercise brings about positive changes in the cardiovascular system, enhancing heart function and oxygen delivery. Immediate ben

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Lipoproteins are compound lipids formed by the aggregation of neutral and amphipathic lipids with proteins (apoproteins). They serve as vehicles for transporting lipids through the bloodstream and lymphatic system, acquiring polarity due to their hydrophilic properties. These macromolecules are synt

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Lipid management in secondary prevention plays a crucial role in reducing cardiovascular risk. This study led by Dr. Timir Paul aims to address system-level gaps in care, enhance communication for optimal therapy, and empower patients in achieving target lipid levels. By recognizing disparities and

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Cholesterol is essential for bodily functions but too much of it can lead to health issues. LDL cholesterol is known as "bad" cholesterol, while HDL cholesterol is considered "good". High cholesterol levels can increase the risk of heart disease and stroke. Managing cholesterol through diet, weight

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Dyslipidemia is characterized by abnormal levels of lipids in the blood, leading to atherosclerosis. Lipid transport mechanisms play a crucial role in the formation and progression of atheromas in artery walls. Chylomicrons carry fats from the intestine to the liver, where they are processed into LD

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Bile acid sequestrants such as colestipol and cholestyramine act by binding bile acids, promoting hepatic conversion of cholesterol, and increasing LDL-receptor activity to clear LDL-cholesterol. They may interfere with fat-soluble vitamin absorption and have common side effects like constipation an

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