Learn about the diagnosis, screening needs, and indications for liver transplant evaluation in patients with cirrhosis. No financial relationships or discussion of off-label medication use or investigational drugs.

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Explore Zilebesiran, an investigational RNA interference therapeutic targeting hepatic AGT synthesis for hypertension. Primary findings from Phase 2 trial KARDIA-1 reveal sustained blood pressure reduction. Addressing the unmet need for innovative antihypertensive treatments.

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The content provides an overview of the IRB review process for research studies, including what necessitates IRB review, the levels of IRB review (exempt, expedited, full board), examples of full board research, and criteria for an Investigational New Drug.

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Acute pulmonary embolism (PE) is a significant issue in hospitalized patients, with current treatments focusing on anticoagulation and systemic thrombolysis. Surgical treatments have shown poor outcomes, leading to a rise in endovascular techniques aimed at reducing clot burden. A survey conducted i

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This article provides insights into the status, regulatory considerations, and delivery methods of gene therapy and genome editing technologies. It discusses approved gene therapies in the US, human genome editing in clinical applications, and the regulatory authority of the FDA over gene therapy. T

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Pharmaceutical processing includes a range of unit operations such as blending, milling, granulation, tablet pressing, coating, and filling, depending on the mode of delivery. With the growing adoption of continuous manufacturing and the rising number of novel therapies in clinical development, phar

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Providing guidance on types of Expanded Access for drugs, biologics, and devices, this content explains the concept of Expanded Access and the criteria that must be met. It covers different types of Expanded Access for drugs and devices, emphasizing the importance of patient safety and benefit. The

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Are you looking for the Best Wellbeing in Cotham? Then visit The Arches Therapy Rooms. Their therapy center boasts a diverse range of services delivered by a team of dedicated professionals, including counseling, holistic therapy, hypnotherapy, acupuncture, and massages. Located in Montpelier, they

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Trafford Talking Therapies is a primary care service offering evidence-based treatments for adults experiencing anxiety and depression. They prioritize perinatal clients from conception to 2 years postpartum, recognizing the importance of parental mental health. The service covers a range of present

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Providing evidence-based treatments for adults with anxiety and depression, Trafford Talking Therapies prioritizes perinatal clients from conception to 2 years, emphasizing the importance of the parent-infant relationship. They offer support for various mental health issues and deliver cognitive-beh

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NHS England's efforts to advance equality in healthcare services recognize the disparities faced by minoritised ethnic groups, particularly in accessing psychological therapies. Recent findings indicate that individuals from these groups experience worse outcomes, longer wait times for assessment an

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Harnessing the power of image-guided therapies, the Society of Interventional Radiology (SIR) believes in pushing the boundaries of medical possibilities to improve patient outcomes, physician insights, and clinical practices. Through research-based outcomes and storytelling, SIR advocates for great

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Ayurveda outlines two main types of therapies - Brihmana (nourishing, enriching) and Langhana (depleting, cleansing) based on the body types of obese and lean. Brihmana therapy focuses on increasing weight and heaviness, while Langhana therapy aims to reduce weight and impart lightness. These therap

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Explore the impact of diabetes worldwide and in South Africa, with a particular focus on the epidemiology, consequences, and current therapies for Type 2 diabetes. Dr. Poobalan Naidoo discusses the increasing prevalence of diabetes and the urgent need for new therapeutic approaches to combat this gr

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An Investigational New Drug Application (INDA) is a crucial submission to the FDA for permission to conduct clinical studies on new drug products. It plays a pivotal role in assessing the safety and efficacy of new drugs before they can be marketed and distributed for human use. This article covers

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Understanding the variety of accessible medical care therapies is fundamental for coming to informed conclusions about your well-being. This article dives into ten normal therapy types, including pharmacological therapies, careful mediation, exercise

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Investigational products play a crucial role in clinical trials, encompassing drugs, devices, biologics, and more. The FDA defines investigational new drugs as substances seeking approval, even if previously in use, with potential changes. Similarly, investigational devices are those under investiga

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Lipid management in secondary prevention plays a crucial role in reducing cardiovascular risk. This study led by Dr. Timir Paul aims to address system-level gaps in care, enhance communication for optimal therapy, and empower patients in achieving target lipid levels. By recognizing disparities and

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Master protocols, seamless trials, and adaptive designs are revolutionizing oncology drug development. These innovative approaches involve multiple substudies with different objectives, evaluating investigational drugs across disease subtypes. Basket trials and umbrella trials offer flexibility in s

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Examining the role of adjuvant therapies in stage IB-IIIA non-small cell lung cancer (NSCLC) post-surgery. Discussion includes the impact of chemotherapy and radiation therapy on overall survival rates and the historical context of adjuvant treatment decisions. Management strategies and consideratio

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Complementary therapies (CT) use, including natural medicine and homeopathy, is on the rise among individuals with and without a breast cancer diagnosis in Chile. While some CTs are not included in the official healthcare package, there is increasing interest in incorporating them due to high satisf

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Highlighting the current guideline recommendations for treating patients with Heart Failure with Reduced Ejection Fraction (HFrEF), this educational slide module emphasizes the importance of implementing the recommended therapies effectively. It covers the foundational treatments recommended by vari

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Learn how to identify common therapies used in HIV/AIDS and TB treatment, understand drug-food interactions and side effects, and provide appropriate nutrition assessment and support to improve treatment outcomes. Service providers play a crucial role in addressing nutritional needs and managing dru

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The Foundation for Prader-Willi Research (FPWR) is a leading organization dedicated to funding research and therapeutic development for Prader-Willi Syndrome (PWS), a complex genetic disorder. PWS poses challenges such as obesity and developmental delays. FPWR aims to accelerate the development of n

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Participants in this workshop will explore Brainspotting (BSP) and other Power Therapies, learning about trauma, its effects, and the power of therapies such as EMDR, TFT/EFT, HAKOMI, PBSP, and more in addressing trauma and promoting healing through heightened bodily awareness and somatic memory ret

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Pain is a complex experience that can be acute or chronic, requiring different treatment approaches. Acute pain alerts us to potential injury, while chronic pain lasts longer and affects quality of life. Management options range from medical and psychological treatments to advanced interventions and

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This content discusses the access to investigational drugs outside of clinical trials, highlighting Treatment Use Criteria and Emergency Use situations. It covers Subpart E regulations, including the definition of life-threatening and severely-debilitating illnesses. The importance of safeguards lik

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Explore targeted treatment approaches for lung cancer through real-life patient cases, expert insights, and updates on therapies. Learn about personalized care, innovative options, and advancements in non-small cell lung cancer treatment. Delve into disclosures from healthcare professionals involved

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Cardiovascular effects of older glucose-lowering therapies and the history of cardiovascular outcome trials are discussed in this educational slide module. It outlines the timeline of treatment options from the discovery of insulin to the introduction of various medications. Evidence regarding the c

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This study evaluates 15 treatment outcome measures for cocaine use across multiple randomized controlled trials from 2000 to present. The criteria include sensitivity to medication and behavioral therapies, post-treatment cocaine use, and general functioning. Various studies focus on treatments such

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This resource provides information on the role of direct care workers in identifying and addressing pain in older adults, funded by The SCAN Foundation. It covers misconceptions about non-drug approaches to pain, various non-drug therapies like physical positioning and music, and tips on when to use

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DEBATECUP is a clinico-pathological syndrome encompassing various cancer types with occult primaries, each exhibiting predictable responses to therapies once classified. Current evidence supports CUP as a collection of specific cancer types with occult primary sites, posing challenges in primary sit

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A 58-year-old man presents with acute severe chest pain, diaphoresis, dyspnea, and risk factors for coronary heart disease. The most likely diagnosis is acute myocardial infarction. Immediate steps include placing the patient on a cardiac monitor, obtaining an ECG, and administering aspirin. Additio

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Explore supportive therapies, stage-based management, natural history, and challenges in Acute Kidney Injury (AKI) along with conservative and pharmacotherapeutic approaches. Learn about the role of diuretics, considerations in established AKI management, and historical perspectives on kidney therap

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Investigational products play a crucial role in clinical trials, encompassing drugs, devices, and biologics that undergo testing to ensure compliance with protocols and participant safety. This comprehensive guide covers the definitions, regulations, and accountability of investigational products in

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Stiriti Ayur Therapies Pvt Ltd, based in Hyderabad, is a professionally managed botanical research and extraction company. With a focus on natural product chemistry, finance, and management, the company offers end-to-end solutions to industry partners through customized research on herbs, herbal ext

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Experts discussed various treatment options for a 60-year-old patient with mCRPC, including switching to Lutetium therapy after progression on Apalutamide. Genetic testing, avoiding back-to-back hormonal therapies, and considering novel AR-blockers like Lutetium-PSMA and PARP inhibitors were highlig

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Explore the selection and sequence of therapy for ER-positive, HER2-negative metastatic breast cancer, along with novel agents and strategies under evaluation. Learn about cases of postmenopausal women with metastatic breast cancer, CDK4/6 inhibitors, and the impact of targeted therapies on patient

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Faculty from different parts of the world presented at the Conference on Retroviruses and Opportunistic Infections in 2023, discussing a randomized study comparing long-acting therapies to oral treatment for HIV. The study, known as SOLAR, showed promising results in virologic outcomes at the 12-mon

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The field of oncology presents unique opportunities for advancing drug development through novel therapeutic modalities like immunotherapies, cell and gene therapies, and radioligand therapies. However, regulators, sponsors, and payers face criticism, often due to non-significant results in overall

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