RNA Interference Therapy Zilebesiran's Impact on Hypertension
Explore Zilebesiran, an investigational RNA interference therapeutic targeting hepatic AGT synthesis for hypertension. Primary findings from Phase 2 trial KARDIA-1 reveal sustained blood pressure reduction. Addressing the unmet need for innovative antihypertensive treatments.
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Liver Transplant in India for treatment
Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper
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adonai software
Adonai college Management System is a cloud-based ERP System that delivers various College and School Management Systems, College and School Management Software, College and School Management System ERP, College and School Management Software System, Online College and School Management Software Sys
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System Models in Software Engineering: A Comprehensive Overview
System models play a crucial role in software engineering, aiding in understanding system functionality and communicating with customers. They include context models, behavioural models, data models, object models, and more, each offering unique perspectives on the system. Different types of system
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Understanding the Nervous System: CNS, PNS, SNS, and ANS
The nervous system comprises the Central Nervous System (CNS) and Peripheral Nervous System (PNS), with the PNS further divided into the Somatic Nervous System (SNS) and Autonomic Nervous System (ANS). The SNS controls voluntary movements of skeletal muscles, while the ANS regulates involuntary proc
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GDS System
Travelopro Global Distribution System (GDS) is a computerized network system. It is a large computer network which is integrated with 100 of worldwide Airlines and consolidators for enabling transactions between travel agents and travel sites and also used by airlines, hotels, car rentals, railways
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Understanding Acetaminophen Poisoning: Mechanism, Toxicity, and Treatment
Acetaminophen poisoning occurs when the body is overwhelmed by high doses of the drug, leading to liver toxicity and potentially fatal consequences. The mechanism of toxicity involves the depletion of glutathione and the formation of a harmful metabolite, N-acetyl-para-benzoquinoneimine (NAPQI). Con
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Understanding the Immune System: Organs, Functions, and Importance
The immune system acts as a defense mechanism against pathogens and infections, comprising various organs, such as the bone marrow, thymus, spleen, white blood cells, antibodies, complement system, and the lymphatic system. It works to recognize and destroy harmful microbes, maintaining the body's h
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Evolution of Land Law Systems in Trinidad and Tobago
Trinidad and Tobago's land law systems consist of the Common Law System and the Registered Land System. The Common Law system governs unregistered land where title passes upon execution and delivery of the deed. In contrast, the Registered Land System confers ownership upon registration and offers c
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Understanding Fat Cow Syndrome in Cattle: Causes, Symptoms, and Treatment
Fat Cow Syndrome, also known as Fatty Liver Disease in Cattle, is a condition commonly seen in high-producing cows during the transition period around calving. The disease is characterized by mobilization of excessive body fat to the liver due to negative energy balance, leading to hepatic lipidosis
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Understanding Computer System Buses: Components and Functions
A computer system comprises three main components - the CPU, memory unit, and I/O devices connected via an interconnection network, facilitated by the system bus. System buses reduce communication pathways, enabling high-speed data transfer and synchronization between components. Internal buses conn
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Understanding Bilirubin: Estimation, Implications, and Causes of Jaundice
Bilirubin, a yellow compound in the catabolic pathway, plays a crucial role in health. Estimating serum bilirubin levels is key in diagnosing conditions like jaundice. Elevated levels, above 2 mg/dl, can indicate disease. Jaundice, characterized by skin and eye discoloration, has pre-hepatic, hepati
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Understanding System Modeling in Engineering
System modeling in engineering involves developing abstract models to represent a system from various perspectives using graphical notations like UML. These models aid in understanding system functionality, communicating with stakeholders, and documenting requirements for new systems. Existing and p
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Rapid Identification System for Inmate Release
The Rapid Identification System, also called Rapid ID System, provides a quick way to verify an inmate's identity using fingerprints before release from custody. It allows law enforcement agencies, including IPD users under SDSheriff, to log in and access the system. By searching the San Diego AFIS
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Nutritional Considerations for Chronic Liver Disease in Critical Care
Malnutrition is common in chronic liver disease, leading to complications such as ascites and infections. Sarcopenia and weight loss are prevalent regardless of BMI. Critical care patients with liver disease face challenges due to limited physiological reserve, with main causes for ICU admission bei
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Understanding Nasopulmonary Drug Delivery System
Nasopulmonary drug delivery system, utilizing the nasal route for drug administration, offers advantages such as hepatic first-pass metabolism avoidance and rapid drug absorption. This system is beneficial for pharmacologically active compounds with poor stability in gastrointestinal fluids. While i
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Understanding Phenytoin Therapy - Clinical Pharmacokinetics and Serum Concentrations
Phenytoin, a medication with high protein binding and hepatic metabolism, exhibits saturated pharmacokinetics with a narrow therapeutic range of 10-20 µg/mL for total serum concentrations. Adverse effects vary with serum levels: minor CNS depression at >15 µg/mL, nystagmus at >20 µg/mL, and ataxi
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Safety and Feasibility of TIPS in Elderly Patients with Liver Cirrhosis
Challenging liver cirrhosis management in elderly patients with refractory ascites has high mortality rates, and transplantation is not always viable. Transjugular intrahepatic portosystemic shunt (TIPS) serves as a non-curative treatment option, aiming to reduce portal hypertension. The procedure i
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Overview of Veins and Venous Circulation in the Body
Veins play a crucial role in the circulatory system by carrying deoxygenated blood back to the heart. This lecture covers the general principles of veins, the anatomy of major veins like the superior and inferior vena cavae, tributaries, and their roles in different parts of the body. It also discus
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System Sequence Diagrams: Understanding Artifact for System Behavior
System Sequence Diagrams (SSDs) are vital artifacts that visually illustrate input and output events related to a system. They help define system behavior and interactions, making them essential during the logical design phase of software applications. By depicting events in sequential order, SSDs o
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Evaluation and Management of Incidental Liver Lesions
Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in
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Portal Vein Imaging Techniques and Anomalies Overview
Portal vein imaging is crucial for evaluating conditions affecting the abdominal part of the gastrointestinal tract. Techniques such as spleno-portography and CT triphasic contrast imaging are used to visualize the portal vein and diagnose anomalies like portal-systemic collaterals and porto-systemi
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Understanding the Anatomy of the Large Intestine
The large intestine plays a crucial role in digestion. This comprehensive overview covers the different parts of the large intestine, characteristic features of the colon, anatomy details, peritoneal covering, relations with surrounding structures, arterial and nerve supply, and important flexures l
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Structure and Function of a Serous Compound Tubulo-acinar Gland
A detailed description of a compound tubulo-acinar gland with serous-secreting nature is provided, highlighting its cellular composition, arrangement of ducts, and connective tissue organization. The glandular structure, including adenomeres, centroacinar cells, and myoepithelial cells, is discussed
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Understanding Complications of Liver Cirrhosis
Recognize major complications of liver cirrhosis including hepatic failure, portal hypertension, ascites, hepatorenal syndrome, and esophageal varices. Learn about the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications.
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Understanding Complications of Liver Cirrhosis
Learn about the major complications of liver cirrhosis, including portal hypertension, hepatic failure, ascites, spontaneous bacterial peritonitis, and more. Explore the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications, and understand the impa
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Benefits of Exercise Therapy in Nonalcoholic Fatty Liver Disease (NAFLD)
Exercise therapy plays a crucial role in managing nonalcoholic fatty liver disease (NAFLD) by improving hepatic aminotransferases and reducing steatosis. Lifestyle modifications, including increased physical activity, are essential in the treatment of NAFLD. This includes aerobic exercise, resistanc
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Hemophagocytic Lymphohistiocytosis (HLH) and Sarcoidosis: A Complex Case Study
This case study delves into a challenging scenario where a hepatologist grapples with a patient presenting HLH associated with liver injury in the context of sarcoidosis. Despite inconclusive initial investigations, further work-up reveals indications of secondary HLH/MAS. The management involves a
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Anatomy and Blood Supply of the Equine Stomach
The equine stomach is relatively small compared to the horse's body size, with distinct regions such as the cardia, fundus, body, and pyloric region. It is located on the left side of the abdomen, under the ribs. The stomach's blood supply includes branches from the aorta, splenic artery, and hepati
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Radiology Imaging of Esophagus and Stomach by Dr. A. Alhawas
View detailed radiology imaging of the esophagus and stomach conducted by Dr. A. Alhawas, showcasing various anatomical structures such as the splenic artery, abdominal aorta, common hepatic artery, and more. Explore pathologically changed layers in pyloric stenosis, arterial blood supply to the pyl
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Functional Anatomy and Blood Supply of the Liver
The liver is a crucial organ with dual functions and a complex anatomical structure. It consists of hepatic lobes and lobules, where hepatocytes play a vital role in various functions. The liver receives blood supply from both the hepatic artery and portal vein, allowing for essential processes such
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Overview of Acute Liver Failure: Causes, Classification, and Diagnosis
Acute liver failure is a severe condition characterized by rapid liver dysfunction within 6 months of symptom onset, leading to encephalopathy, coagulopathy, and jaundice. This condition can be classified as hyperacute, acute, subacute, fulminant, or sub-fulminant based on the duration from jaundice
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Understanding Drug-Induced Liver Injury (DILI)
Drug-induced liver injury (DILI) can present as cholestasis, hepatocyte necrosis, steatosis, vascular damage, and hepatic fibrosis. Various drugs like antibiotics, NSAIDs, recreational drugs, and herbal remedies can cause liver damage. Recognizing DILI is crucial in patients with liver dysfunction o
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Hydropericardium Hepatitis Syndrome (HHS) in Poultry: Causes, Symptoms, and Prevention
HHS is an acute infectious disease in chickens characterized by high morbidity and mortality, excess pericardial fluid, and multifocal hepatic necrosis. It mainly affects broilers and broiler parents, with clinical signs such as sudden mortality, lethargy, and ruffled feathers. Post-mortem lesions i
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Nutrition and Cystic Fibrosis: Management of CF-Related Complications
Explore the nutrition implications and management strategies for CF-related liver disease, gastrointestinal complications, and CF-related diabetes in patients. Learn about the proposed mechanisms, prevalence rates, and consequences of hepatic complications in cystic fibrosis. Gain insights into neon
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Understanding Bile Acid Sequestrants and Fibrates in Clinical Pharmacy
Bile acid sequestrants such as colestipol and cholestyramine act by binding bile acids, promoting hepatic conversion of cholesterol, and increasing LDL-receptor activity to clear LDL-cholesterol. They may interfere with fat-soluble vitamin absorption and have common side effects like constipation an
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Strategies for Enhancing Extended Producer Responsibility System in Bulgaria
Korea-Bulgaria Knowledge Sharing Program focused on sharing strategies to enhance Bulgaria's Extended Producer Responsibility (EPR) system. The program discusses the current status, performance evaluation, issues, and recommendations related to the EPR system in Korea. It covers topics like beverage
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Challenges in the Management and Treatment of HIV/Hepatitis C Virus Coinfection
This presentation by Dr. Ricardo A. Franco focuses on the challenges faced in managing and treating patients with HIV/Hepatitis C virus coinfection. It discusses the burden of HCV mono-infection and HIV/HCV co-infection, the impact of HIV co-infection on survival in HCV-related cirrhosis, and the ro
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Understanding Drug Metabolism and Excretion in the Human Body
In the realm of pharmacology, the process of eliminating drugs from the body involves hepatic metabolism, biliary elimination, and urinary excretion. Once a drug is introduced into the system, these routes of elimination come into play, highlighting the crucial role they play in drug clearance and e
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Understanding Serum Bilirubin: Types, Estimation, and Causes of Jaundice
Serum bilirubin levels are crucial in diagnosing conditions like jaundice, with total, direct, and indirect bilirubin playing key roles. Excess bilirubin in the blood can lead to jaundice, characterized by yellow discoloration of the skin and eyes. Different types of jaundice, including pre-hepatic,
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