Consultant Nephrologist Paraskevi Liaveri discusses the association between SGLT-2 inhibitors and acute kidney injury (AKI). Pharmacovigilance reports highlight a higher risk of AKI with these drugs, especially when combined with RAAS blockers, diuretics, or NSAIDs. Studies suggest potential mechani

0 views • 49 slides

Peptic ulcer disease (PUD) involves ulcerations in the duodenal or gastric mucosa caused by factors like Helicobacter pylori infection and NSAID use. Symptoms include abdominal pain and nausea, and treatment often involves H. pylori eradication and proton pump inhibitors to prevent complications lik

1 views • 77 slides

Human heart development begins in the 3rd week of gestation with the formation of heart tubes that eventually differentiate into various cardiac structures. The heart undergoes folding and septation processes during development, leading to the formation of crucial septa. Molecular regulation, involv

3 views • 62 slides

Major lipids like cholesterol and triglycerides play essential roles in the body, but their excess can lead to hyperlipidemia and related conditions. This overview covers the biosynthesis of cholesterol, triglycerides, and the transport of lipids in the bloodstream, discussing the importance of lipo

1 views • 30 slides

The AMPK system plays a crucial role in regulating energy homeostasis by sensing the cellular AMP:ATP ratio and responding to metabolic stresses that affect ATP production or consumption. AMPK is activated by factors such as hypoxia, glucose deprivation, and metabolic inhibitors, as well as by compo

0 views • 27 slides

COX enzymes, including COX1, COX2, and COX3, play a crucial role in synthesizing prostanoids like prostaglandins in the body, affecting pain and inflammation. By inhibiting these enzymes, relief from pain and inflammation can be achieved. However, non-selective COX inhibitors may lead to various sid

0 views • 21 slides

This presentation covers drugs for hyperlipidemia, including bile acid sequestrants, cholesterol absorption inhibitors, statins, fibrates, and relevant drug interactions. It details the actions, adverse effects, contraindications, and notable considerations for each drug class. The included multiple

0 views • 6 slides

Enzyme activity is influenced by various factors such as enzyme concentration, temperature, pH, substrate concentration, inhibitors, activators, and physical agents. The rate of enzyme-catalyzed reactions is directly proportional to enzyme concentration, and temperature plays a significant role with

0 views • 23 slides

Define oxidation, reduction, oxidizing agent, reducing agent, standard electrode potential, Nernst equation, and corrosion in the context of chemical engineering. Discuss different forms of corrosion, including uniform corrosion, galvanic corrosion, pitting corrosion, and stress corrosion. Explore m

0 views • 20 slides

Explore the classification of antihypertensive agents used in treating hypertension, including beta blockers, centrally acting agents, ganglionic blockers, ACE inhibitors, vasodilators, and more. Learn about the Renin-Angiotensin System, ACE inhibitors, and specific drugs like Captopril and Benazepr

0 views • 9 slides

Plant growth regulators, also known as phytohormones, are organic compounds produced naturally in plants to control growth and physiological functions. They include auxins, gibberellins, cytokinins, ethylene, growth regulators, and inhibitors. Auxins, for example, promote growth along the plant's lo

2 views • 28 slides

Pet Food Ingredients Market By Pet (Dog, Cat, Fish, and Others), By Ingredients (Specialty Proteins, Amino Acids, Mold Inhibitors, Gut Health Ingredients, Phosphates, Vitamins, Acidifiers, Carotenoids, Enzymes, Mycotoxin Detoxifiers, Flavors & Sweete

1 views • 4 slides

Lubricants are substances introduced between moving surfaces to reduce friction, heat generation, and wear and tear of machine parts. They act as thermal barriers, coolants, seals, and corrosion inhibitors. Good lubricating oils have high boiling points, adequate viscosity, and non-corrosive propert

1 views • 25 slides

Cognitive enhancers play a crucial role in managing Alzheimer's Disease, with Cholinesterase inhibitors (AChEI) like Donepezil, Galantamine, and Rivastigmine recommended for mild to moderate AD, and Memantine for moderate to severe cases. These medications act through different mechanisms, with AChE

0 views • 46 slides

Explore the factors influencing enzyme activity, such as substrate and enzyme concentration, temperature, pH, and inhibitors. Learn how to simulate enzyme kinetics using equipment like popping beads and stopwatches. Analyze results to understand the impact of substrate concentration on reaction rate

0 views • 22 slides

Antiviral chemotherapy plays a crucial role in preventing and treating viral infections, especially when public health measures and vaccines are not sufficient. This form of treatment has been successful in combating diseases like HIV by inhibiting viral replication and targeting specific functions

1 views • 34 slides

The development of antimicrobial drugs has significantly improved therapeutics by controlling infections and preventing complications. These drugs target invading microorganisms using selective toxicity, sparing host cells. Antimicrobial drugs are classified based on site, mechanism of action, and c

0 views • 30 slides

Cholinergic neurons play a vital role in neurotransmission by utilizing acetylcholine (ACh) as a neurotransmitter. This neurotransmission involves steps like synthesis, storage in vesicles, release, receptor binding, degradation, and recycling of choline and acetate. Choline acetyltransferase cataly

0 views • 30 slides

Enzyme inhibition plays a crucial role in pharmacology and biochemistry by regulating enzymatic reactions. Inhibitors can be reversible or irreversible, affecting enzyme activity differently. Competitive, uncompetitive, and noncompetitive inhibition types are explained along with examples like diiso

0 views • 20 slides

This presentation delves into exponential growth functions using real-world examples such as the population growth of Niger. It covers topics such as algebra with exponents, finding formulas for growth models, terminology, and graphing population growth over time. The content explores how exponentia

1 views • 21 slides

Nitric oxide (NO), a vital molecule formed from arginine, plays diverse roles in the body including vasodilation, neurotransmission, platelet regulation, and immune response. Its formation involves a complex enzyme called nitrogen oxide synthase. Various inhibitors and clinical implications, such as

0 views • 19 slides

The DAPA-HF trial investigated the use of dapagliflozin, an SGLT2 inhibitor, in patients with heart failure and reduced ejection fraction, regardless of diabetes status. Funded by AstraZeneca, the study enrolled 4,744 patients from 20 countries, showing promising results in reducing cardiovascular d

3 views • 22 slides

In this experiment, the effect of inhibitors on enzymatic reactions, specifically acid phosphatase, is explored. Different types of inhibition (competitive, noncompetitive, uncompetitive) are examined, along with reversible and irreversible inhibitors. The study aims to determine the type of inhibit

1 views • 17 slides

Stress Corrosion Cracking (SCC) is a type of corrosion where the metal gets cracked due to the presence of a corrosion medium and tensile stress conditions. Factors influencing SCC include environmental composition, stress, metal composition, and temperature. Prevention methods involve selecting sui

0 views • 12 slides

The British Association of Dermatologists conducted a national clinical audit program in 2015 to evaluate atopic eczema in children based on NICE guidelines. The audit included contributions from BAD and BSPD members, as well as private providers. It involved 128 submissions from 98 centers, with 12

2 views • 18 slides

Antibiotic prescribing in patients on protein pump inhibitors (PPIs) is associated with an increased risk of Clostridium difficile infection. A review was conducted on high-risk antibiotic prescriptions, revealing instances where patients were prescribed against guidelines, leading to potential comp

0 views • 5 slides

Antipsychotics and antidepressants play crucial roles in treating psychological and affective disorders in veterinary medicine. Antidepressants are vital in managing abnormal mood and behavior linked to depression, while antipsychotics help address various nervous disorders. The classification of an

0 views • 11 slides

Highlighting the current guideline recommendations for treating patients with Heart Failure with Reduced Ejection Fraction (HFrEF), this educational slide module emphasizes the importance of implementing the recommended therapies effectively. It covers the foundational treatments recommended by vari

0 views • 28 slides

Dormancy in plants, involving seeds and buds, is a state where growth is temporarily halted due to internal or external factors. Factors like immature embryos, impermeable seed coats, and growth inhibitors contribute to seed dormancy. The presence of inhibitors like abscisic acid and the influence o

0 views • 43 slides

Oregon's Growth Model for education accountability uses a system that compares student growth to academic peers in the state. School growth ratings are determined based on levels of growth in reading and math, with a focus on tracking student progress over time. By comparing growth percentiles and s

0 views • 25 slides

Growth charts are essential for assessing children's growth, with WHO setting international standards since 2006. The discussion includes interpreting growth charts, the history of growth references, and the difference between reference and standard growth. It compares CDC's U.S. growth reference to

0 views • 30 slides

Explore the logistic growth equation and its applications in modeling population dynamics. Dive into the concept of sigmoidal growth curves and the logistic model, which reflects population growth with limits. Learn how to calculate population change using the logistic growth equation and understand

0 views • 26 slides

Discover how PDE-5 inhibitors go beyond treating erectile dysfunction, with approved and emerging compounds, alternative dose regimens, concentration sites, and potential targets like cardiovascular diseases and the central nervous system.

0 views • 47 slides

Exploring the use of mTOR inhibitors in liver transplantation for hepatocellular carcinoma (HCC), this content presents recent study results and experiences from the Korean population. It discusses the preventive potential of mTOR inhibitors in HCC recurrence based on previous studies and the need f

0 views • 32 slides

This educational slide module provides an overview of the guideline recommendations for SGLT2 inhibitors in the treatment of heart failure, including HFrEF, HFmrEF, and HFpEF. It covers recommendations from AHA, ACC, HFSA, ESC, CCS, and CHFS guidelines, highlighting the role of SGLT2 inhibitors as a

0 views • 28 slides

In this detailed overview, we explore antifungal inhibitors and drugs, including their mechanisms of action, impact on eukaryotes and prokaryotes, common agents affecting fungal sterols and cell walls, as well as synthetic antifungals. From polyenes like nystatin to azoles such as voriconazole, this

0 views • 12 slides

Organisms carefully control enzyme production and activation as per varying needs and conditions within cells. Enzyme activity is influenced by factors such as pH, temperature, regulatory molecules, cofactors, compartmentalization, covalent modification, and feedback inhibition. Enzymes can be regul

0 views • 20 slides

This study compares the efficacy and safety of different protease inhibitors (PIs) including ATV, ATV/r, LPV/r, FPV/r, DRV/r, and SQV/r in HIV treatment. The ARTEMIS study specifically focuses on comparing DRV/r and LPV/r in combination with TDF/FTC in ARV-naive patients. Results show non-inferiorit

0 views • 12 slides

Explore the selection and sequence of therapy for ER-positive, HER2-negative metastatic breast cancer, along with novel agents and strategies under evaluation. Learn about cases of postmenopausal women with metastatic breast cancer, CDK4/6 inhibitors, and the impact of targeted therapies on patient

0 views • 23 slides

PCSK9 inhibitors are a novel class of medications that help lower LDL cholesterol levels, reducing the risk of cardiovascular events. This article covers their mechanism of action, patient groups benefiting from them, efficacy in LDL-C lowering, and safety considerations. Learn how PCSK9 inhibitors

0 views • 8 slides