This article provides insights into the status, regulatory considerations, and delivery methods of gene therapy and genome editing technologies. It discusses approved gene therapies in the US, human genome editing in clinical applications, and the regulatory authority of the FDA over gene therapy. T

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Learn how to incorporate Universal Design for Learning (UDL) principles with social annotation using Hypothesis Workshop. Discover the benefits of social annotation, ways to align it with UDL, practical assignment examples, and engage in interactive sessions. Join the workshop to enhance student eng

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Explore the world of genome assembly, shotgun sequencing, and the fundamental concepts behind deriving genomes from large sets of sequencing reads. Learn about the complexity and core algorithms involved in contemporary genome assembly processes. Discover how the shotgun concept has revolutionized g

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A study on sudden death and cardiomyopathy in Nova Scotia Duck Tolling Retrievers due to LMNA association. The research includes genetic mapping, genotype verification, and functional predictions on Lamin A/C effects. Echocardiogram findings, pedigree data, genome-wide association study, whole-genom

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Explore the essentials of Genome-Wide Association Studies (GWAS) and genetic data quality control as presented by Daniel Howrigan in the 2023 workshop. Delve into the goals of GWAS, genetic data characteristics, SNP variations, and genotyping techniques. Gain insights into moving from trait heritabi

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The lecture covers the transcription and translation processes of virus genomes, including the Baltimore classification system, transcription control in eukaryotes, and the role of transcription factors in gene expression. It explores how different viruses replicate based on their genome type and me

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Genome assembly is a technique to assemble short DNA fragments into a organized format.

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Developed by Genomics Education Programme, these slides focus on the patient choice consent model for whole genome sequencing in NHS Genomic Medicine Service. The model aims to ensure informed choices for genomic testing, including participation in the National Genomic Research Library. It covers se

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A case report explores the use of optical genome mapping (OGM) to unravel a complex KMT2A rearrangement in an AML patient. Traditional cytogenetic analyses identified translocations and rearrangements involving chromosomes 10 and 11, leading to the fusion of genes KMT2A and MLLT10. OGM technique, ut

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The Cancer Genome Atlas (TCGA) project, initiated in 2005, aims to identify genetic mutations in cancer through genome sequencing. Supervised by the Center for Cancer Genomics, TCGA has expanded over the years, publishing numerous research articles and involving various tumor types. The project has

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This conversation with Dr. Samantha Evans, Director of Evaluation at Genome Canada, delves into the importance of program evaluation in genomic science. Genome Canada aims to connect ideas, invest in science and technology, and maximize impacts across sectors. The evaluation process involves collect

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Genome alignment plays a crucial role in understanding biological processes and evolutionary history. With the rise of whole genome sequencing, methods such as constrained alignment and longest increasing subsequence have been employed for accurate variant detection. Tools like BLAST, hash tables, a

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DNA, the hereditary basis of life, was first discovered by Friedrich Miescher in 1869. It consists of chromosomes, plasmids, and organellar DNA, collectively known as the genome. Genes, sequences of DNA, encode proteins and RNA, essential for an organism's functions. The genome is divided into chrom

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Uncover the fascinating journey of molecular biology, tracing key milestones from the discovery of DNA to the intricate structure of genes and genomes. Dive into historical breakthroughs, such as understanding the role of genes in producing proteins, the double helix structure of DNA, and the comple

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Chromosomes are the carriers of genetic information in cells, containing genes made of DNA. Chromatin, composed of DNA wrapped around histone proteins, plays a crucial role in organizing genetic material. Humans have 23 pairs of chromosomes, and the Human Genome Project aims to map the human genome.

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This content provides information about a Genome Informatics course, including course logistics, homework policies, and contact details. It also introduces fundamental concepts such as algorithms, their key features, and examples like finding the smallest number among inputs. The course emphasizes l

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Today's session covers topics such as Python dictionaries with in-class examples, iterating through dictionary entries, counting repeating characters in a string, and understanding if/elif/else statements. The session also includes a discussion on combining tests in Python and comparisons operators.

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Delve into the realm of bacterial comparative genomics with insights on terminologies, assembly methods, annotation processes, and two key approaches to microbial genomics. Explore the basics of genomics terminology, assembly-based and variant-based analyses, as well as annotation methods for protei

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Presentations at CLARIN 2020 Session focused on annotation and visualization tools, including a neural syntax annotator for Dutch and German, exploring and visualizing Wordnet data with GermaNet Rover, named entity recognition for distant reading in ELTeC, and the semi-automatic analysis of spontane

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Explore the integration of CMDI for metadata editing in resources, including open/closed vocabularies, Arbil interface for vocabulary management, ELAN for resource annotation, and KinOath for kinship data. Discover how CMDI improves data annotation and vocabularies management in linguistic research.

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ELAN, a tool developed over 15 years at the Max-Planck-Institute for Psycholinguistics, is utilized in various research contexts like language documentation, acquisition studies, gesture studies, and sign language studies. The workshop covers the introduction to ELAN, basic and advanced features, an

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This workshop delves into the analysis of argumentative discourse units in online interactions, emphasizing the segmentation, classification, and relation identification processes. It discusses challenges in annotation and proposes a two-tiered annotation scheme involving expert annotators and novic

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The Human Genome Project, completed in 2003, aimed to identify all human genes and DNA sequences. Genetic disorders, like autosomal disorders and Huntington's disease, can result from mutations at different levels, affecting single genes, chromosomes, or multiple genes. Albinism and cystic fibrosis

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Presentation at the Sunflower Genome Consortium Meeting in San Diego discussed the use of PacBio sequencing to enhance the sunflower genome assembly, with evaluations on PacBio data's effectiveness at locus and genome scales. Results highlighted challenges and successes in improving assembly quality

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Genome projects generate large GFF files which require significant storage space. GPress offers a solution by compressing GFF files while allowing quick searches and random access. The framework addresses challenges faced by current GFF utilities, providing a more efficient approach to managing and

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GenPIP is an innovative system that accelerates genome analysis through tight integration of basecalling and read mapping. By utilizing chunk-based pipelines and early rejection techniques, GenPIP optimizes data processing, reducing wasted computation and data movement. The system outperforms existi

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Functional Annotation of Animal Genomes (FAANG) is crucial for associating sequence variation with quantitative phenotypes in domestic animals, serving as important models for human health, disease, and ecology. The NIH actively participates in various genome projects involving cattle, horses, and c

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A cognitive study on extracting subjectivity in sentiment annotation, exploring if humans perform subjective extraction similarly to machines for sentiment analysis. The study investigates sentiment oscillations and different methods adopted based on the nature of subjective documents.

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Exploring the portrayal of sexual intercourse in Ghanaian films against cultural values, this study introduces a multimodal annotation scheme for analysis. Addressing concerns raised by the public, it delves into the complexities of conveying sex in a culture that tends to discourage open discussion

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The Open Source Software initiative progress update provides insights into the work accomplished during e-meetings, focusing on the development of a modular annotation tool shared by a focus group. The group's activities, such as drafting requirements, analyzing survey results, and setting up collab

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Obesity is a prevalent issue with individuals seeking ways to change their health behaviors. The article explores a dialogue annotation scheme using the Trans-Theoretical Model of Health Behavior Change. It delves into stages like precontemplation, contemplation, preparation, action, and maintenance

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NDV, a pleomorphic virus, has an irregular spherical shape with filamentous features. Its genome consists of a single-stranded RNA with six genes arranged in a specific order. The virus contains a lipoprotein envelope with short spikes and a helical nucleocapsid core to protect the RNA. The genomic

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Addressing the challenge of acquiring labelled data for NLP models, weak supervision techniques offer solutions through alternative annotation methods and leveraging diverse data sources. This talk highlights the importance of overcoming the scarcity of labelled data in machine learning and NLP task

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GWAS, or Genome-Wide Association Studies, are a method used to map genes associated with traits or diseases by analyzing genetic markers throughout the genome. This process involves statistically testing the association between SNPs and traits using regression or chi-squared tests in a hypothesis-fr

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This training activity conducted by the New York Integrated Food Safety Center of Excellence in October 2019 focuses on educating public health staff/students on the application of Whole Genome Sequencing (WGS) and whole genome multi-locus sequence typing (wgMLST) for subtyping. Through a mock case

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Compilation and annotation of a discourse-structured blog corpus for German, involving data collection, annotation, addressing specific problems, and planning next steps. The project focuses on fostering interoperability, meeting requirements, and developing models for annotating blogs' structural a

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Cauliflower Mosaic Virus (CaMV) is a plant virus studied by Assistant Professor Kavita Basumatary at Goalpara College. The virus has a circular, double-stranded DNA genome of about 8000 bp in length with unique discontinuities. Reproduction involves the viral genome entering the host cell nucleus, w

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Genome browsers are essential tools for visualizing complex genome information, integrating sequence data with annotations in a user-friendly graphical interface. They enable exploration of chromosomal regions, regulatory elements, and comparative genomics across different organisms. Key examples in

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Large-scale DNA editing of retrotransposons plays a crucial role in accelerating mammalian genome evolution. Retrotransposons, accounting for half of the human genome, are mobile elements that can lead to mutations and genetic disorders but also serve as a reservoir for genetic innovation, rewiring

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Video transcription services are integral to accurate AI annotation and training. They convert video content into structured, annotated datasets, enhancing model accuracy, scalability, and efficiency. Discover their applications and benefits for AI d

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