Cholestatic liver disease affects Alkaline Phosphatase (ALP) and bilirubin levels, indicating bile duct damage. GGT and 5'-Nucleotidase help differentiate hepatobiliary vs. bone origin of ALP elevation. ALP is produced by bile duct epithelium and can be normal in acute biliary obstruction. GGT and N

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Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a

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Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper

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Liver complications in cystic fibrosis (CF) have gained importance due to CFTR modulators impacting liver health. This presentation by Dr. Zachary M. Sellers delves into new definitions for CF liver disease, CFF recommendations for screening, management, and treatment of hepatobiliary issues in CF.

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Best Liver Transplant Hospitals in India\nThe liver is a vital organ that performs important functions in the human body, including detoxification, metabolism, and the production of essential proteins. However, certain conditions such as liver failure, cirrhosis, or liver cancer may necessitate a li

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In this informative content, the histological structures of the liver and spleen are explored in detail. Key components such as hepatocytes, sinusoids, bile canaliculi, and the spaces of Disse in the liver, and the white pulp and red pulp in the spleen are highlighted. The classic liver lobule, cent

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The Annual Report on Liver Transplantation 2021/22 presents detailed statistics and clinical research findings from the NHS Blood and Transplant BLTG Transplant Meeting in September 2022. The report covers an overview, transplant list, donor and organ supply, transplant activity, and outcomes. It hi

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Fat Cow Syndrome, also known as Fatty Liver Disease in Cattle, is a condition commonly seen in high-producing cows during the transition period around calving. The disease is characterized by mobilization of excessive body fat to the liver due to negative energy balance, leading to hepatic lipidosis

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Malnutrition is common in chronic liver disease, leading to complications such as ascites and infections. Sarcopenia and weight loss are prevalent regardless of BMI. Critical care patients with liver disease face challenges due to limited physiological reserve, with main causes for ICU admission bei

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The liver services at Imperial College Healthcare NHS Trust, led by Dr. Ameet Dhar, provide a comprehensive range of services for patients with liver conditions. With over 2000 new patients seen annually, services include inpatient care, specialist clinics, outreach programs, and referral pathways.

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Abnormal liver function tests can be a perplexing issue with various underlying causes. Dr. Heather Lewis, a renowned Consultant Hepatologist at Imperial College Healthcare NHS Trust, sheds light on the significance of liver function tests, liver enzymes, and blood markers in diagnosing liver condit

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These slides provide a comprehensive overview of the EASL clinical practice guidelines on nutrition in chronic liver disease. The guidelines were first presented at the International Liver Congress 2018 and will soon be published in the Journal of Hepatology. The content covers methods of grading ev

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Explore the world of fatty acids and derived lipids through detailed images and descriptions. Learn about the chemical structure, composition, and various types of fatty acids found in the human body. Discover how fatty acids are essential components of lipid forms and play a crucial role in biologi

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Lipids are diverse organic compounds vital for metabolism and cell functions. They are insoluble in water, serve as energy sources, aid in hormone synthesis, and form cell membranes. Fatty acids, the building blocks of lipids, provide fuel for the body. Saturated fatty acids have high melting points

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Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in

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Delve into a comprehensive overview of the liver's anatomy, including ligaments, blood supply, and structure in the hilum. Explore the vital functions performed by the liver, such as maintaining body temperature, synthesizing clotting factors, and drug metabolism. Discover liver function tests and t

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Liver biopsy plays a crucial role in diagnosing, staging, and prognostic evaluation of liver diseases in children. Indications for liver biopsy include diagnostic, prognostic, and monitoring purposes. Specific scenarios like neonatal cholestasis and progressive familial intrahepatic cholestasis requ

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This article explores the complex biochemical pathways involved in the metabolism of fatty acids and their conversion into various metabolites. Fatty acid metabolites play essential roles in cellular energy production, signaling, and structural funct

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Coconut oil, derived from mature coconuts, is rich in saturated fats and widely used in food, medicine, and industry. Fatty acids play crucial roles in human health, with different types impacting metabolism differently. Coconut oil's unique fatty acid composition sets it apart from oils like corn o

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The liver plays a crucial role in detoxification and maintaining harmony in the body according to Traditional Chinese Medicine (TCM). Issues like liver disharmony can lead to various symptoms and health conditions. TCM emphasizes the importance of supporting liver function for overall well-being by

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A phase 2 study on NGM282 in NASH patients showed a significant decrease in liver fat content, meeting the primary endpoint. Exploratory findings also indicated potential improvements in liver histology. The treatment involved NGM282 at 3 mg QD, with additional rosuvastatin if needed. Promising resu

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Medical Nutrition Therapy (MNT) plays a crucial role in managing Non-alcoholic Fatty Liver Disease (NAFLD), focusing on insulin resistance, metabolic syndrome, oxidative stress, dyslipidemia, and cardiovascular risk. Lifestyle recommendations include weight management and increasing physical activit

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Comprehensive discussion on assessing patients with abnormal liver test results, focusing on distinguishing between acute and chronic liver conditions. Covers diagnostic workup, patient cases, and differential diagnosis, emphasizing the importance of patient history, physical examination, and key di

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This comprehensive review discusses the pharmacotherapy options for Non-Alcoholic Fatty Liver Disease (NAFLD), covering topics such as sub-classification of NAFLD, proposed risk stratification, non-invasive measures for assessing liver fibrosis, and the NAFLD Activity Score (NAS). Anita Eftekharzade

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Exercise therapy plays a crucial role in managing nonalcoholic fatty liver disease (NAFLD) by improving hepatic aminotransferases and reducing steatosis. Lifestyle modifications, including increased physical activity, are essential in the treatment of NAFLD. This includes aerobic exercise, resistanc

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CYNOBIL liver capsules offer comprehensive liver support with a natural blend of silymarin, artichoke extract, and NAC. Improve liver function, detox, and digestion with CYNOBIL by LYF Healthcare.\n

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Ascites, jaundice, and confusion in a 50-year-old man raise concerns about liver disease. Differential diagnosis includes cirrhosis, malignancy, alcoholic liver disease, and biliary obstruction. Physical examination findings such as spider naevi, hepatomegaly, and asterixis help narrow down the poss

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Explore the process of fatty acid oxidation in zoology, including the entry of fatty acids into mitochondria, TCA cycle outcomes, and differences between mitochondrial and peroxisomal oxidation. Learn about the oxidation of saturated, monounsaturated, and polyunsaturated fatty acids through detailed

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Seafood lipids, including Tiger shrimps like Peaneus monodon, are rich in essential fatty acids such as EPA, DHA, and AA. This study focuses on the fatty acids profile, atherogenic (IA), and thrombogenic (IT) health lipid indices of fresh and sundried Tiger shrimps, shedding light on the effects of

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This presentation discusses the principles, causes, presentations, management, and prognosis of acute liver disorders, with a focus on insult to the normal liver leading to liver injury, inflammation, and necrosis. It covers causes such as drugs, viruses, ischemia, autoimmune conditions, Budd-Chiari

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Acute liver disorders can have various causes such as drugs, viruses, ischemia, autoimmune conditions, and more. The presentations of acute liver disease can include abnormal liver tests, jaundice, liver impairment, and even liver failure. Management involves removing and treating the underlying cau

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Drug-Induced Liver Injury (DILI) is a serious concern that can lead to fatal liver damage, affecting drug development and potentially causing market withdrawal. This article explores the importance of DILI awareness, the critical functions of the liver, common causes of liver failure, and the backgr

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Guideline drafted by Dr. Sally Hull and Dr. Lucy Carter focuses on identifying patients at risk of chronic liver disease, increasing testing for treatable liver conditions, and auditing prevalence of major liver diseases. The importance of diagnosing Non-Alcoholic Fatty Liver Disease (NAFLD) and str

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Dr. Somen Banerjee, Director of Public Health in London Borough Tower Hamlets, highlights the concerning liver disease mortality rates in the area, with high incidence of cirrhosis, cancer, and hepatitis B and C. The data reveals a significant burden of liver diseases such as Non-Alcoholic Fatty Liv

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The liver carries out essential metabolic, excretory, protective, synthetic, and storage functions in the body. Liver function tests play a crucial role in screening for liver dysfunction, recognizing patterns of liver disease, assessing patient prognosis, monitoring disease progression, and evaluat

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This presentation delves into the intricacies of acute kidney injury (AKI) and its occurrence in patients with liver disease in the intensive care unit (ICU). It covers the definitions, classifications, and causes of AKI, emphasizing the Hepatorenal Syndrome, a form of functional renal failure in en

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Drug-induced liver injury (DILI) can present as cholestasis, hepatocyte necrosis, steatosis, vascular damage, and hepatic fibrosis. Various drugs like antibiotics, NSAIDs, recreational drugs, and herbal remedies can cause liver damage. Recognizing DILI is crucial in patients with liver dysfunction o

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The liver plays a crucial role in metabolism, coagulation, and immune function. Surgical diseases of the liver, such as liver cysts and cavernous haemangiomas, can impact its normal functions. Imaging modalities like ultrasound (US), CT scans, and MRI are essential for diagnosing and staging liver t

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This guidance provides detailed information on COVID-19 and liver disease, covering topics such as COVID-19 overview, liver test abnormalities, co-morbidities, viral hepatitis B and C, metabolic dysfunction, autoimmune hepatitis, clinical care aspects, complications management, screening for HCC, an

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Qualitative tests of lipids distinguish between oil, neutral fat, saturated fatty acids, and unsaturated fatty acids using methods like the copper acetate test. Derived lipids include substances like cholesterol and fat-soluble vitamins that are either soluble in lipids or derived from lipids throug

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