The evidence-based science and clinical management of Cardiovascular-Kidney-Metabolic Syndrome (CKM) in this comprehensive slide set. Learn about the pathophysiological interactions, multi-organ dysfunction, and adverse cardiovascular outcomes associated with CKM.

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The increased risk of cardiovascular disease in people with HIV and specific strategies to treat it. This presentation discusses potential mechanisms, comorbidity gaps, and the impact of traditional risk factors. Explore the role of inflammation and immune dysfunction in atherosclerosis and vulnerab

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Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a

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Shock is a critical condition caused by an imbalance between cellular oxygen supply and demand, leading to organ dysfunction. Compensatory responses include increased heart rate, vasoconstriction, and hormonal adjustments. Recognizable features of shock include tachycardia, hypotension, cool clammy

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Pituitary disorders, often caused by tumors, can disrupt hormone production leading to various symptoms like weight gain, vision problems, and hormonal imbalances. The pituitary gland plays a crucial role in regulating bodily functions through hormone secretion. Factors such as tumor growth, head in

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Neuropsychological assessment plays a vital role in understanding brain-behavior relationships. This process involves determining cerebral functioning, identifying dysfunction, and assessing cognitive abilities through a combination of interviews, observational data, and testing. The assessment aids

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The Bleeding Time (BT) test evaluates platelet plug formation and capillary integrity, crucial for surgery preparations. Prolonged bleeding times indicate low platelet count or dysfunction. The Duke method is one way to determine Bleeding Time. Sources of error, such as medication interference, impr

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This study explores the use of CSL-112 infusions in patients with acute myocardial infarction to enhance high-density lipoprotein (HDL) function. By focusing on improving HDL-C function through ApoA-1 infusions, the research aims to enhance outcomes associated with cardiovascular events. The efficac

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The kidney is a two-bean-shaped organ in the human body that filters waste products, excess fluids, and poisons from the blood. It also contributes to overall health by controlling blood pressure, electrolyte balance, and red blood cell synthesis. But certain medical diseases, such as chronic kidney

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Cystic Fibrosis (CF) is a genetic disease caused by variants in the CFTR gene. CFTR is a crucial membrane protein responsible for chloride transport in epithelial cells, impacting organ function. The Modulator Era focuses on CFTR modulators approved by the FDA for treating CF and improving outcomes.

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Acute calculous cholecystitis is a common digestive disease with varying treatment perspectives. The Tokyo Guidelines 2018 provide criteria and severity grading for the diagnosis of acute cholecystitis. Diagnosis involves local and systemic signs of inflammation along with specific imaging findings.

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Amyloidosis is a disorder characterized by the deposition of abnormal amyloid fibrils in tissues, impacting various organs. This condition is associated with different types of amyloid, such as AA and AL amyloid. The deposition of amyloid can lead to tissue damage and organ dysfunction. Primary and

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Long Covid, also known as post-Covid condition, refers to persistent symptoms lasting at least 2 months after the initial Covid-19 infection. Symptoms can include fatigue, shortness of breath, and cognitive dysfunction, impacting daily life. Around 10-30% of Covid patients may experience Long Covid,

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Pulmonary Function Tests (PFTs) are vital for assessing pulmonary gas exchange through ventilation, diffusion, and lung perfusion. These tests include measurements of lung volume, airway patency, gas exchange efficacy, and pulmonary blood flow. PFTs offer benefits in diagnosing dyspnea, monitoring d

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Posterior Tibialis Tendon Dysfunction, also known as Adult Acquired Flat Foot Deformity (PTTD), is a condition that affects the tibialis posterior tendon, leading to reduced arch support. Common causes include obesity, trauma, age, and existing health conditions. Symptoms may include ankle pain, swe

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Understanding the prevalence, structure, and classification of TMJ dysfunction is vital in the diagnosis and orthopedic treatment of patients. Anamnesis, symptoms evaluation, and etiology of disc displacement play crucial roles in identifying the underlying issues. This comprehensive guide sheds lig

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Hereditary Connective Tissue Disorder, Hypermobile Ehlers-Danlos Syndrome (hEDS), and Mast Cell Activation Syndrome (MCAS) are three complex conditions with overlapping symptoms affecting collagen, joint laxity, and immune responses. Features associated with these conditions include joint pains, gas

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Anaphylaxis is a severe allergic reaction that can be life-threatening if not managed promptly. It manifests with symptoms like rash, mucosal swelling, difficulty breathing, and reduced blood pressure. This reaction is classified as anaphylactic shock, a type of shock involving circulatory and organ

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Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

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Hearing loss is a prevalent issue affecting millions of adults globally, with aging being a significant factor. The impact of hearing loss includes increased risks of cognitive dysfunction, depression, social isolation, and economic burdens. Audiologists play a crucial role in the assessment, manage

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Chronic otitis media is a persistent inflammation of the middle ear mucosa and mastoid process for more than 3 months. It can be classified as tubotympanic or attico-antral, with the new classification including inactive and active mucosal and squamous types. The condition is influenced by factors l

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Explore the classification of antihypertensive agents used in treating hypertension, including beta blockers, centrally acting agents, ganglionic blockers, ACE inhibitors, vasodilators, and more. Learn about the Renin-Angiotensin System, ACE inhibitors, and specific drugs like Captopril and Benazepr

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Alkalosis in cattle, particularly ruminal alkalosis, can be caused by issues such as abomasal atony and alkaline indigestion. Excessive intake of protein-rich feed and changes in diet play a significant role. Pathophysiology involves the accumulation of ruminal ammonia, leading to alkaline pH and ru

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Sexual dysfunction encompasses a range of issues that can affect individuals, with causes including psychological, neurological, hormonal, and relationship-related factors. Evaluating sexual problems involves considering duration, context, and frequency. Psychological causes, such as anxiety and str

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Discover the intricate anatomy of the spine, learn about the prevalence and causes of lower back pain, delve into the symptoms and diagnosis of sacroiliac joint dysfunction, and explore treatment options to manage this condition effectively.

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Cerebral Palsy (CP) is a clinical syndrome characterized by motor dysfunction and non-progressive brain damage affecting an immature developing brain. This article explores the definition, risk factors during prenatal, natal, and postnatal periods, and the pathology associated with CP, including dif

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Overview of theories of causation categorized into psychological, social psychological, and sociological perspectives. Psychological theories focus on instinctive, biological, and psychological qualities of abusers, including Attachment Theory, Psychodynamic Theory, Social Learning Theory, and Situa

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Movement dysfunction in sports medicine can stem from various factors such as structural instability, loss of range of motion, functional rigidity, poor balance, and more. Clinical movement analysis plays a vital role in identifying muscle imbalances and guiding exercise interventions to enhance ath

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Executive Functioning is a key aspect of cognitive function, encompassing various abilities such as planning, self-awareness, and emotion regulation. Executive Dysfunction, often resulting from frontal lobe injuries, can lead to difficulties in decision-making, social interactions, and learning. Thi

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An intriguing case study presents a young male with weakness and coma in the ICU following pneumonia and sepsis. Nerve conduction results indicated critical illness myopathy and polyneuropathy, along with cardiac abnormalities. Reduced muscle excitability was attributed to a sodium channelopathy. Th

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This consensus statement by the American Head and Neck Society Endocrine Surgery Section highlights the importance of recognizing immediate vocal fold paralysis (VFP) and partial neural dysfunction (PND) following thyroid and parathyroid surgery. The report emphasizes the need for early identificati

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Understanding cognitive dysfunction in cancer patients is crucial for improving quality of life and medical outcomes. This article explores the background, causes, screening, diagnosis, and treatment options for cancer-related cognitive impairment, emphasizing the historical perspective, prevalence,

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Discover how PDE-5 inhibitors go beyond treating erectile dysfunction, with approved and emerging compounds, alternative dose regimens, concentration sites, and potential targets like cardiovascular diseases and the central nervous system.

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Radioactive iodine (RAI) is commonly used in treating differentiated thyroid cancer but can lead to salivary and lacrimal dysfunction. This joint clinical consensus statement by the American Head and Neck Society Endocrine Surgery and Salivary Gland Sections highlights the importance of understandin

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This research explores mapping the MMPI-2-RF substantive scales onto internalizing, externalizing, and thought dysfunction dimensions in mental health assessment. The study emphasizes the importance of validating assessments for accurate clinical pictures and effective treatment planning. It delves

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Pelvic floor dysfunction and prolapse are common issues affecting women, impacting their physical and emotional well-being. Surgical treatment may be necessary for symptomatic cases, but a thorough evaluation of symptoms, obstetric history, and other factors is crucial. Addressing precipitating fact

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Cardiorenal Syndrome is a condition where dysfunction in one organ, whether acute or chronic, can lead to dysfunction in the other. This complex relationship involves intricate communication pathways between the heart and kidneys, impacting hemodynamic stability, organ perfusion, and neurohormonal i

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The research explores the association between taste perception and the duration of COVID infection in long-COVID and COVID-reinfection cases. Reduced salivary gustin levels correlated with lower taste scores in long-COVID patients. The study also found an increase in the bitter taste receptor gene e

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Primary ovarian insufficiency, also known as hypergonadotropic amenorrhea, is a condition characterized by ovarian dysfunction in women under 40. It involves oligo/amenorrhea, elevated FSH levels, and impacts fertility and overall health. The pathophysiology includes follicle depletion and dysfuncti

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Voiding disorders in children, also known as bladder dysfunction, are a common issue affecting up to 40% of pediatric urology clinic visits. These disorders can indicate underlying pathophysiology requiring treatment to prevent renal or urologic damage. The development of urinary control by age 5 is

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