Learn about the causes, symptoms, and effects of Vitamin A deficiency, including night blindness, corneal keratinization, and impaired immune function. Explore the epidemiology and pathogenesis of this condition.

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Iron deficiency is prevalent in heart failure patients with reduced ejection fraction and is linked to poor outcomes. The HEART-FID trial investigates the impact of intravenous ferric carboxymaltose (FCM) on all-cause mortality, heart failure hospitalizations, and exercise capacity in chronic HFrEF

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Enzymes, as proteins acting as biological catalysts, accelerate chemical reactions without being consumed. They have active sites where substrates bind, and their specificity can be lock-and-key or induced fit. Enzymes are named based on their function or the substrates they interact with. Enzyme sp

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Phosphatase enzymes play a crucial role in various metabolic processes by releasing phosphate groups, increasing their availability for energy synthesis and cell structure formation. Acid phosphatases, with an optimum pH below 7.0, can be extracted from plant tissues like germinating mung beans. A p

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Mental deficiency, also known as intellectual disability, is characterized by significantly below-average intellectual functioning before the age of 18, along with limitations in adaptive behaviors. It is measured using standardized IQ tests, with classifications ranging from profound to mild. Two m

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The learning content discusses enzymes as biological catalysts that increase reaction rates by lowering activation energy. It explores how enzyme activity efficiency is influenced by factors such as temperature, pH, and substrate concentration. The Induced Fit Model is analyzed to explain how enzyme

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The content discusses the amino acid sequence alignment and phylogenetic tree analysis of enzyme sequences, specifically DcLCYB2, among different plant species including Daucus carota, Carica papaya, Citrus maxima, Solanum lycopersicum, and Crocus sativus. The study explores the genetic relationship

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Nutritional diseases arise from imbalances between the body's nutrient and energy requirements and their supply. Nutritional deficiencies can lead to clinical diseases, while excessive intake can result in diseases of affluence. Common nutritional disorders include low birth weight, PEM, obesity, go

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Bioprocessing utilizes biological materials for commercial, medical, and scientific purposes, leveraging natural biological activities to develop useful products. This branch of biotechnology offers advantages such as low temperature, pressure, and pH requirements, along with renewable resources for

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Cholestasis is characterized by reduced bile flow and elevated direct bilirubin. It is critical to differentiate it from neonatal jaundice. In conditions like biliary atresia and 1-antitrypsin deficiency, early diagnosis and intervention are crucial to prevent liver failure. Clinical manifestations

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Explore the effects of pineapple enzyme bromelain on gelatin and how pasteurization can alter its effectiveness in this lab experiment. Discover the different outcomes when using fresh versus canned pineapple and formulate hypotheses to guide the investigation. Follow step-by-step procedures to test

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Enzyme activity is influenced by various factors such as enzyme concentration, temperature, pH, substrate concentration, inhibitors, activators, and physical agents. The rate of enzyme-catalyzed reactions is directly proportional to enzyme concentration, and temperature plays a significant role with

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Enzymes play a crucial role in catalyzing biochemical reactions by forming enzyme-substrate complexes and facilitating changes in substrate molecules to product molecules. The process involves four steps: proximity of enzyme and substrate, binding at the active site, catalysis leading to substrate a

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Demonstrating the enzyme activity of peroxidase, an enzyme that plays a crucial role in breaking down hydrogen peroxide in various organisms. Learn about the differences between peroxidase and catalase, the calculation of enzyme activity, and the significance of extinction coefficient in enzyme assa

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Vitamin B12 deficiency is a complex condition with various manifestations, including neurological symptoms. The updated guidelines address key areas such as neuro symptoms, coeliac disease, and transitioning from intramuscular to oral treatment. Testing indications and approaches for pernicious anae

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Enzyme kinetics is a vital discipline focusing on the rate of enzyme-catalyzed reactions and how they respond to varying conditions. Reactions are classified based on reactant concentration influences. Zero, first, second, and third order reactions are distinguished, with examples like first-order r

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Salivary amylase, an enzyme found in saliva, partially hydrolyzes starch into maltose. This practical involves observing the action of salivary amylase on starch, demonstrating how starch is broken down into glucose and maltose. The procedure includes preparing solutions, collecting saliva, mixing w

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Enzyme immobilization involves confining enzymes on inert supports for stability and reuse, enhancing efficiency and cost-effectiveness. Historical events and examples illustrate various methods and applications. Chemical modifications, such as PEG addition, have shown increased enzyme activity. The

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Explore the factors influencing enzyme activity, such as substrate and enzyme concentration, temperature, pH, and inhibitors. Learn how to simulate enzyme kinetics using equipment like popping beads and stopwatches. Analyze results to understand the impact of substrate concentration on reaction rate

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A 78-year-old man presents with symptoms of fatigue, headache, and abdominal pain, leading to a diagnosis of iron deficiency anemia. His medical history includes hypertension, type II diabetes, and chronic shoulder pain. Investigations reveal hypochromic, microcytic anemia with low iron levels and h

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This interactive content provides a detailed exploration of enzyme activity through data interpretation and graph analysis. Questions range from identifying the impact of enzymes on specific molecules to determining optimal conditions for various enzyme functions such as pH and temperature. Users de

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Post-Parturient Haemoglobinuria (PPH) is a metabolic disease affecting high-producing dairy cows after calving, characterized by hemolysis, hemoglobinuria, and anemia. Common in buffaloes and cows, it is caused by phosphorus deficiency in diet, affecting intracellular functions and leading to clinic

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Enzyme immobilization involves confining enzyme molecules to a distinct phase from substrates and products, attaching them to solid matrices for enhanced specificity and reduced inhibition. Inert polymers or inorganic materials are used as carrier matrices with methods like physical adsorption onto

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Enzyme inhibition plays a crucial role in pharmacology and biochemistry by regulating enzymatic reactions. Inhibitors can be reversible or irreversible, affecting enzyme activity differently. Competitive, uncompetitive, and noncompetitive inhibition types are explained along with examples like diiso

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The content discusses the alignment of various plant enzyme amino acid sequences, including DcLCYB1, DcLCYB2, and DcLCYE, among different inbred lines. It also explores the construction of DcLCYs for enzyme activities using an E. coli complementation assay. The phylogenetic relationship between DcLC

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Salivary enzyme amylase, also known as ptyalin, plays a crucial role in breaking down starch and glycogen into maltose. This practical session in the Zoology department explores the action of salivary enzyme amylase at a temperature of 37°C and pH of 6.6. By conducting experiments with starch, iodi

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Vitamin K deficiency in animals can lead to serious health issues due to its crucial role in blood clotting and bone metabolism. Different sources of vitamin K, such as plant material and bacterial fermentation, provide essential forms like K1 and K2. Factors contributing to deficiency include fat m

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Farmers can benefit from Marketing Assistance Loans (MAL) and Loan Deficiency Payments (LDP) to manage cash flow and ensure price floors for their harvested grain. MAL offers low-interest loans while LDP provides payments if prices fall below a certain level, offering financial support during challe

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Hyperglycemic crises such as Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar State (HHS) are life-threatening emergencies characterized by severe hyperglycemia and metabolic imbalances. DKA involves absolute or near-absolute insulin deficiency leading to ketone body production and systemi

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Elemental analysis of human fingernails is conducted using Laser-Induced Breakdown Spectroscopy (LIBS) to diagnose and monitor zinc deficiency in the body. Zinc deficiency is a significant health issue globally, affecting billions of people. By utilizing LIBS technology on fingernail samples, resear

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This session, led by Dr. Patrick Asamoah Sakyi from the Department of Earth Science at UG, delves into the significance of geological elements in human health, discussing diseases arising from their deficiency or excess intake. Topics include geophagy, fluorine's impact on dental health, iodine defi

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Vitamin E deficiency in poultry can lead to serious conditions such as encephalomalacia (crazy chick disease) and exudative diathesis. Symptoms include ataxia, testicular degeneration, and early embryo mortality. Post-mortem lesions show soft and swollen brains with minute hemorrhages. It is crucial

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Explore key topics in haematology such as leucopenia, B12 deficiency, and myelodysplastic syndrome with detailed guidance on interpreting full blood counts, red flags, investigations, and management strategies. Learn about special situations like B12 deficiency in pregnancy and malabsorption issues.

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Exploring enzyme assays in biotechnology, covering topics such as ELISA, protein assays, enzyme activity measurement techniques, specific activity, terminology related to enzyme assays, and different types of experiments conducted by biochemists to study enzyme-catalyzed reactions. The content delve

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Cyanide, a noncompetitive inhibitor of the enzyme cytochrome c oxidase, disrupts electron transport in respiration by binding to the iron cofactor and blocking electron transfer to oxygen. This lethal effect was utilized in gas chambers during WWII, underscoring the crucial role of enzyme function i

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Ongoing work includes progress on CPIC guidelines for aminoglycosides, clopidogrel, and statins, along with evidence reviews for various enzymes and medications. A review of G6PD deficiency and rasburicase safety is being conducted, categorizing drugs as low-to-no risk, high-risk, or medium-risk bas

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In multisubstrate enzyme kinetic mechanisms, the apparent Km and Vmax values change with varying substrate concentrations. Different kinetic mechanisms like rapid equilibrium Bi Bi and ordered Bi Bi reactions can occur. The ping-pong Bi Bi reaction involves oscillation between enzyme forms. Various

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Copper deficiency in ruminants can be primary or secondary, affecting enzyme activity and gene expression. Risk factors include diet, soil characteristics, and breed. Pathogenesis involves effects on tissues, wool loss, body weight, diarrhea, anemia, bone health, and heart function.

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Polyphenol oxidase (PPO) is a copper-containing enzyme with an optimal pH of 6.7 that catalyzes the oxidation of phenols, leading to color changes like browning in fruits and potatoes. This experiment aims to demonstrate PPO activity, its chemical nature, substrate specificity, and the effects of te

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Enzyme assays measure substrate conversion to product under varying conditions like cofactors, pH, and temperature. Enzyme velocity represents the rate of a catalyzed reaction, typically reported as V0. Enzyme activity is expressed as mol of substrate transformed per minute, with enzyme unit and kat

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