HER2 activation plays a crucial role in promoting tumor proliferation and survival in NSCLC. Driven by oncogenic downstream signaling pathways, HER2 overexpression and gene amplification lead to the formation of heterodimers and activation of key signaling cascades. Additionally, HER2 mutations are

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This slideshow provides an overview of tumor classification, nomenclature, and key concepts in pathology. It covers the definitions of neoplasm, tumor, and oncology, the classification of tumors into benign and malignant categories, as well as the importance of stroma in tumor behavior. It also expl

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Is your dad the king of terrible puns? Does his love for dog-gone hilarious jokes never sit down? Then the \"Emergency Dog Jokes\" mug is the perfect Father's Day gift to keep him well-armed with canine comedy!\n\n

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Discover the best spine tumor treatment at Medspine, the leading hospital with top surgeon and specialist in Medavakkam, Perumbakkam, Royapettah, Chennai.

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Located in scenic Vero Beach, Applied Canine Concepts LLC is a prime puppy training Vero Beach. They specialize in individualized programs that emphasize positive reinforcement, forming well-rounded peer groups. Where appropriate, their service includes essential obedience training and behavior modi

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Applied Canine Concepts LLC of Vero Beach is synonymous with best dog trainer Vero Beach. Our experienced teachers use positive reinforcement techniques to effectively address obedience and behavioral challenges. We offer programs tailored to each dog\u2019s personality and needs, whether it\u2019s

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Applied Canine Concepts LLC of Jupiter specializes in professional dog training Jupiter. Positive reinforcement techniques are used to effectively address behavioral issues to increase compliance. Offering personalized training programs tailored to individual needs, solutions are offered from basic

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Based in Vero Beach, Applied Canine Concepts LLC is dedicated to providing best dog training Vero Beach that cover both obedience and behavior modification. Nestled in the serene coastal setting of Vero Beach their expert trainers use personalized techniques to best meet the unique needs of each dog

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Canine Monocytic Ehrlichiosis is a tick-borne disease caused by Erhlichia species, primarily affecting dogs. This article covers the pathogenesis, clinical findings in different phases (acute, subclinical, and chronic), and associated symptoms. Learn about the transmission, distribution, and potenti

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Grading and staging are crucial in determining the aggressiveness and extent of malignant tumors. Grading involves assessing the level of malignancy based on cell differentiation and mitotic activity, while staging considers the size of the tumor, lymph node involvement, and presence of metastases.

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Canine Viral Infection, caused by canine parvovirus-2, is a highly contagious disease affecting dogs, especially puppies. The infection spreads through fecal-oral route and can lead to severe clinical signs like vomiting, diarrhea, and dehydration. The virus replicates in lymphoid tissues, affecting

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This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with

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WAGR syndrome is a rare genetic condition associated with Wilms Tumor, aniridia, and developmental delays. Wilms Tumor is a form of kidney cancer mostly affecting children and is linked to genetic disorders like WAGR syndrome. The risk of Wilms Tumor is higher in children with WAGR syndrome, with po

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Canine Infectious Hepatitis (ICH), also known as Rubarth's Disease, is caused by Canine Adenovirus-1 (CAdV-1), affecting dogs of all ages. The virus primarily targets hepatocytes, leading to acute hepatitis, as well as respiratory and ocular issues. Transmission occurs through contact with infected

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Positron Emission Tomography (PET) is a medical imaging technique focusing on metabolic differences in the body. By using positron-emitting radioisotopes, PET can detect how molecules are taken up by healthy and cancerous cells, aiding in accurate tumor localization with lower doses. The evolution o

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Research collaboration aimed to enhance locoregional tumor control and reduce distant failure by combining charged particles irradiation and anticancer drug Epothilone B in cultured human tumor cells from Milano and Roma. The study explores the impact on clonogenic survival, growth curves, and deter

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Kennel Cough, known as Canine Infectious Tracheobronchitis, is a highly contagious respiratory disease affecting dogs, characterized by acute tracheobronchitis and a paroxysmal cough lasting several days. It is caused by various infectious agents, including Canine Parainfluenza Virus and Bordetella

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The Gamma Knife Stereotactic Radiosurgery is a precise and effective treatment method where highly focused radiation beams are used to target tumors and abnormalities in the brain. It does not remove the tumor directly but affects DNA, cell growth, and blood vessels. The procedure involves three mai

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NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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This collection of images and information delves into the intricacies of how dogs communicate through vocalizations, body postures, and behaviors. It emphasizes the importance of observing various cues like ear positions, tail positions, and gaze to interpret a dog's emotional state accurately. By p

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This study by Shyamala Maherswaran, Ph.D., and team focuses on characterizing mutations in EGFR in circulating tumor cells using SARMS assay and CTC-chip. The research investigates the effectiveness of these non-invasive methods in analyzing tumors and explores the role of the T790M mutation in resp

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This collection of supplementary figures provides detailed flow cytometry data on immune cell populations, including CD4+ T cells, CD8+ T cells, tumor-associated macrophages, and more. The figures also include information on immune checkpoint molecules like PD-L1 and TIGIT. Each figure presents spec

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Vestibular schwannoma, also known as acoustic neuroma, is a common tumor in the cerebellopontine angle. It can be sporadic or associated with neurofibromatosis type 2. Patients typically present with hearing loss and tinnitus, which may be gradual or sudden. Grading systems like Koos, Ojemann, and J

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Neoplasia encompasses abnormal tissue growth that can be benign or malignant. This article explores neoplastic terms, tumor classifications, cancer staging, and genetic factors in cancer development. Gain insights into the characteristics of benign tumors, the biology of cancer including carcinogene

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Canine mammary neoplasms, including benign adenomas and malignant carcinomas, are common in intact female dogs. This article discusses the clinical signs, diagnosis methods like FNAC and biopsy, WHO clinical staging system, and the importance of palpating regional lymph nodes for prognosis assessmen

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Understanding the classification of tumors is crucial in the field of pathology. This detailed overview covers the definitions of neoplasia and tumors, the differentiation between benign and malignant tumors, nomenclature, and characteristics of various tumor types. It discusses the behaviors of ben

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The study evaluates the efficacy and toxicity of carboplatin in treating macroscopic non-osseous sarcomas in dogs. The research focuses on soft tissue sarcomas (STS) and mesenchymal tumors, exploring carboplatin's limitations, response rates, and toxicity profiles. Aimed at determining the drug's ef

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This study focuses on using mass spectrometry to analyze cerebrospinal fluid (CSF) proteomics in dogs with non-infectious meningoencephalitis, aiming to identify unique peptide signatures for improved diagnosis and monitoring. The research addresses the diagnostic and therapeutic limitations of this

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This tutorial, prepared by the International Working Group for TIL in breast cancer, provides guidelines for pathologists on the standardized evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer based on H&E slides of core biopsies or tumor resections. It details steps such as defini

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Craniopharyngioma is a complex intracranial tumor with a rich historical background dating back to the early 20th century. Initially described by McLean, Frazier, Alpes, and famously studied by Cushing, this tumor continues to be a subject of debate and controversy in terms of treatment approaches a

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The study evaluates the MURR Thermal BNCT Facility's effectiveness in treating canine nasal/sinus tumors using a phantom. The facility, located at the University of Missouri Research Reactor, offers Boron Neutron Capture Therapy (BNCT) under the direction of Dr. Fred Hawthorne. Key features include

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This study explores the problem of finding the largest area axis-aligned B-empty rectangle containing n red points and m blue points. The research discusses various extensions to the original problem, such as the Blue Rectangles problem and the Outliers Problem, aiming to achieve efficient solutions

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Canine diabetes mellitus is a common disease in dogs, primarily affecting middle-aged and older dogs. Unlike Type 2 diabetes in humans, dogs mainly experience insulin-dependent Type 1 diabetes. The condition results from beta cell dysfunction in the pancreas, leading to insulin deficiency. Causes in

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Cancer's complex evolution introduces challenges in treatment response. B-SCITE aims to enhance tumor phylogeny inference by integrating bulk sequencing and single-cell data using a probabilistic approach. It addresses the complexity of tumor cell populations and potential treatment failure causes.

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Learn about the eligibility requirements for sitting for the Certified Tumor Registrar (CTR) examination, which include formal education and experience. Discover the different paths to meeting the eligibility criteria, such as obtaining an Associate's Degree in Cancer Registry Management or gaining

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Study focuses on Canine Meningoencephalitis of unknown etiology using Pan-Viral PCR to detect infectious agents in cerebrospinal fluid samples. The research aims to identify aberrant immune responses in dogs with MUE. Consensus degenerate primers are used to target viral families like Herpesviridae,

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Cr(VI)-induced mutagenesis is a key event in the mode of action for small intestinal tumors in mice, with the question of whether it is an essential step in tumor development. The interaction of cellular components with Cr leads to cell proliferation, hyperplasia, and ultimately mutagenesis. Differe

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Canine distemper virus (CDV) poses a significant threat to various carnivore species, including domestic dogs, foxes, wolves, raccoons, bears, and others. This highly contagious disease has been linked to fatalities in lions and emphasizes the importance of understanding its pathology and impact on

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Hemangiopericytoma is a rare soft tissue tumor originating from pericytes in capillaries. Learn about its symptoms, diagnosis methods, treatment options, and the role of pathology and IHC. Follow-up care, adrenal tumor functionality, and potential associations with MEN syndrome are also discussed.

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Dr. Dilip S. Kiyawat, an experienced M.Ch. (Neuro) Neurosurgeon, offers advanced brain tumor surgery with expert care. Services include precise diagnosis, minimally invasive techniques, advanced imaging, and post-surgery care. Book your consultation

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