Immune deficiencies can be classified into primary hereditary disorders based on clinical presentations, including cell-mediated, antibody-mediated, non-specific, and complement activation deficiencies. Major clinical manifestations of immune disorders range from B-cell deficiencies to phagocytic ce

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Explore the fundamentals of immunology with insights into immunogens, antigens, epitopes, and haptens. Uncover how these key components play vital roles in shaping immune responses and learn about paratopes, the basis of immunogenicity, and the key events that determine foreignness in the immune sys

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Human blood groups are determined by the presence or absence of specific antigens and antibodies. The ABO system categorizes blood into four types (A, B, AB, O), while the Rh factor (D antigen) determines whether blood is RhD positive or negative. Blood group antigens are crucial for safe transfusio

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HIV, a member of the lentivirus subfamily of retroviruses, causes Acquired Immunodeficiency Syndrome (AIDS). HIV-1 and HIV-2 have distinct characteristics, with HIV-1 being global and HIV-2 primarily in West Africa. The virus encodes reverse transcriptase and has an envelope containing glycoproteins

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Human blood types are determined by specific antigens and antibodies present on red blood cells, influencing crucial aspects like blood transfusions and familial relationships in forensic medicine. The ABO system, with its four main blood types (A, B, AB, O), plays a vital role in categorizing blood

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Immunity is the body's defense mechanism against diseases. Active immunity occurs through exposure to antigens, either naturally during infection or artificially through vaccines. It leads to the production of memory cells for long-lasting protection. On the other hand, passive immunity involves rec

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Dive into the world of immune system glossary terms with definitions and visual aids. Explore key concepts such as immune cell activation, adaptive immune response, antibodies, antigens, and more. Understand the complex processes within the immune system through informative images and concise explan

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This overview delves into the CareStart COVID-19 antigen test, touching on its approval status, intended use, safety precautions, how the test works, proper disposal and cleanup methods, and the importance of Personal Protective Equipment (PPE) during testing. The test involves specific procedures w

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Immunoassay is an analytical method utilizing specific antibody-antigen reactions to determine reactant amounts. This method involves competitive binding between labeled and unlabeled analytes and specific antibodies. Antibodies, antigens, labels, and separation matrices play crucial roles in immuno

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Viral gastroenteritis is an inflammation of the gastrointestinal tract primarily affecting the stomach and small intestine, leading to symptoms like acute diarrhea and vomiting. It can be caused by various infectious agents such as Rotavirus, Adenovirus, Caliciviruses, Astrovirus, Coronavirus, Torov

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Antigens are substances that stimulate the production of antibodies in the body, exhibiting specificity in immune reactions. They interact with immune response products like antibodies, BCRs, and TCRs. Immunogens induce detectable immune responses, leading to antibody production or T cell activation

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Monoclonal antibodies are created using hybridoma cells that can produce specific antibodies and divide rapidly. These antibodies, which target specific antigens, have various applications in medicine, such as in cancer treatment and pregnancy tests. By harnessing the immune system's abilities, mono

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Klebsiella species, such as K. pneumoniae and K. oxytoca, are gram-negative bacilli commonly found in the microbiota of the intestines, nasopharynx, and feces. They exhibit distinct characteristics like pink mucoid colonies on MacConkey's agar and are known to cause both community-acquired and hospi

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Proteus species, named after the Greek god Proteus, exhibit pleomorphism. Their historical importance stems from the unique characteristics of H and O antigens, with flagellated strains resembling a thin film on agar. Pathogenically, Proteus mirabilis and P. vulgaris are opportunistic pathogens caus

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Antigen-antibody precipitation reaction involves the formation of insoluble products when a soluble bivalent antibody interacts with a soluble antigen. This reaction leads to the formation of a visible precipitate known as a lattice. The mechanism of precipitation, including the prozone phenomenon,

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Inflammation is a crucial process in response to tissue injury, aiming to eliminate harmful agents and promote healing. It involves vascular changes, increased permeability, and the formation of edema. Repair follows inflammation, involving regeneration and fibroblastic tissue formation. While infla

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Agglutination reaction is a key technique in immunology where particulate antigens and antibodies clump together in the presence of electrolytes. This reaction is highly sensitive and often used for antibody detection, bacterial identification, blood grouping, and cross-matching. The process involve

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This content delves into the mechanisms of antibody-mediated immunity, focusing on B-cells as key players in humoral immunity. It covers topics such as activation of B-cells, clonal selection, generation of plasma and memory cells, primary and secondary immune responses, and the structure and functi

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Learn about antigens, immunogenicity, antigenicity, and epitopes in immunology. Antigens are substances with distinct immunologic properties, while immunogenicity refers to the ability of an antigen to induce an immune response. Antigenicity is the ability of an antigen to combine specifically with

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Complement Fixation Test (CFT) is a key immunological method used to detect specific antibodies in a patient's serum by using complement proteins. This test involves the stages of incubation with antigens, inactivated serum, and complement, followed by the indicator stage using sheep red blood cells

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Specimen selection for viral testing depends on the suspected viral etiologies and disease syndrome. Throat and nasopharyngeal swabs are used for different viruses, while rectal swabs, urine, blood, and tissue samples are also collected for specific viral detection. Proper specimen transport and sto

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Immunity is the body's defense mechanism against pathogens, encompassing innate and acquired immunity. It involves resistance to infections and foreign antigens, inherited or acquired. Innate immunity provides the first line of defense, while acquired immunity can be active or passive. Species immun

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ABO blood grouping and Rh factor testing are crucial for blood transfusions and forensic medicine. The presence or absence of specific antigens and antibodies in human blood determines blood type. Genetic inheritance from parents establishes blood type, with codominance influencing offspring phenoty

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Blood matching for patients is crucial to prevent adverse reactions like hemolysis and death. ABO and RhD compatibility testing are fundamental, along with selecting antigen-negative units for patients with clinically significant antibodies. Beyond mandatory requirements, matching can be complex due

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Proteus species, specifically P. mirabilis and P. vulgaris, are important opportunistic pathogens in human infections. They exhibit unique characteristics such as swarming growth on agar, gram-negative coccobacilli morphology, and distinctive antigenic structures with O and H antigens. The swarming

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The immune system maintains a balance through tolerance mechanisms to prevent autoimmunity. Central and peripheral tolerance play crucial roles in immune unresponsiveness to self-antigens. Failure in immune regulation can lead to autoimmune diseases like diabetes and lupus. Vaccination, discovered b

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Antibodies against antigens in the major histocompatibility complex play a crucial role in kidney transplant rejection. Different types of donor-specific antibodies can lead to rejection at various stages post-transplantation. Methods to discover donor-specific anti-HLA antibodies include complement

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Hypersensitivity in immunology refers to an altered immune response against antigens, leading to hyperreactivity and immunopathology. This article delves into the different categories of adaptive hypersensitivities, focusing on Immediate (Type I), Antibody-Mediated Cytotoxic (Type II), and Immune Co

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Hypersensitivity reactions occur in sensitized hosts following contact with specific antigens, leading to injurious consequences. The Gell and Coombs Classification categorizes reactions into Type I, II, III, and IV based on immune response and duration. Type I reactions are immediate and humoral, w

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Explore the structure and functions of antibodies, including how they bind to antigens, act as opsonins, agglutinins, and anti-toxins. Learn about the specificity of antibodies, their variable regions, and their role in neutralizing pathogens and viruses. Gain insights into how antibodies help the i

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Agglutination testing is a common method used in laboratory medicine to detect the presence and amount of antigens or antibodies in patient samples. It involves the use of carrier particles such as latex, RBCs, charcoal, and protein A of Staph aureus. The testing process includes qualitative and qua

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Cryptococcal Immune Reconstitution Inflammatory Syndrome (C-IRIS) is a condition where rapid reversal of immunodeficiency triggers exaggerated inflammatory reactions in response to Cryptococcus antigens. It can manifest as either Unmasking IRIS or Paradoxical IRIS, with common CNS presentations incl

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Avian influenza, or bird flu, is a viral disease affecting birds' respiratory, digestive, and nervous systems. It presents in two forms - Highly Pathogenic Avian Influenza Virus (HPAIV) and Low Pathogenic Avian Influenza Virus (LPAIV). The virus has two important surface antigens, Hemagglutinin (H)

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The history and advancements in cancer immunotherapy are highlighted, from early observations in the 1890s to the development of modern immunotherapies in the 2000s. Concepts such as immunosurveillance theory and the role of T cells in recognizing tumor-associated antigens are discussed, leading to

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The Enterobacteriaceae family comprises a diverse group of gram-negative rods commonly found in the gut of humans and animals, known for causing various diseases. Key members include Escherichia coli, Shigella, Salmonella, Klebsiella, and more. They are facultative anaerobes, ferment glucose, lack c

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Streptococci are Gram-positive cocci commonly found in chains or pairs. This article covers their classification based on hemolysis patterns and Lancefield grouping, along with general characteristics and principles of differentiation tests. Learn about the infections caused by different Streptococc

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ELISA (Enzyme-Linked Immunosorbent Assay) is a vital immunological technique used in detecting antigens or antibodies in samples. This article covers the types of ELISA tests, such as Direct, Indirect, and Sandwich, along with the principles and applications of ELISA in diagnosis. The process involv

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Immunohistochemistry (IHC) is a technique used to detect antigens in tissue sections by utilizing antibodies that bind specifically to target antigens. This method has evolved since the 1930s and plays a vital role in disease diagnosis, drug development, and biological research. IHC combines anatomi

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ELISA (enzyme-linked immunosorbent assay) is a widely used laboratory technique for detecting and quantifying antigens or antibodies in blood samples. Introduced in 1971, ELISA involves an antigen-antibody reaction using enzyme-conjugated antibodies to generate a colored product on a plate. There ar

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The humoral basis of immunity involves the specific reaction between antigens and antibodies, resulting in the formation of insoluble precipitates through a process called precipitation. This reaction plays a crucial role in immune responses against infectious diseases, influenced by factors like af

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