Acoramidis, a next-generation TTR stabilizer, shows promising results in improving cardiac function and promoting regression in Transthyretin Amyloid Cardiomyopathy. The ATTRibute-CM Cardiac Magnetic Resonance Substudy evaluated changes in cardiac structure, function, and amyloid burden after treatm

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Amyloidosis is a disorder characterized by the deposition of abnormal amyloid fibrils in tissues, impacting various organs. This condition is associated with different types of amyloid, such as AA and AL amyloid. The deposition of amyloid can lead to tissue damage and organ dysfunction. Primary and

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Special stains in pathology provide crucial diagnostic information beyond routine stains like H&E. They help highlight specific tissue components like carbohydrates, amyloid, nucleic acids, lipids, microorganisms, connective tissues, pigments, and minerals. This article delves into the classificatio

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The Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) commenced in late 2006, with a cohort size and follow-up progress detailed. The study includes assessments and biomarker imaging, such as MRI, amyloid PET, and tau PET scans, with ongoing review cycles and data additions. Current

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Analysis conducted at the Perelman School of Medicine, University of Pennsylvania, evaluated the predictive performance of cerebrospinal fluid markers A1-42, t-tau, and p-tau181 on cognitive decline and progression to dementia. The study included 2401 ADNI1/GO/2 CSF samples from individuals across d

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Cell injury can result from multiple stressors such as hypoxia, physical agents, chemicals, microbes, immunologic factors, nutritional imbalances, and aging. This can lead to reversible changes (degeneration) or irreversible changes (necrosis). Types of degeneration include cloudy swelling, hydropic

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The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing began in 2006 with PiB and MRI assessments. Over time, the study has expanded to include more participants and various imaging modalities. Current focuses include converting amyloid results to centiloid units, exploring blood b

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This informative content discusses morphological patterns of cell injury, focusing on reversible cell injury or degeneration caused by intracellular and interstitial accumulations. It covers classifications such as primary changes in the cell, intracellular accumulation of water, fat, carbohydrates,

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The MGB Alzheimer Therapeutics Program is a collaborative effort leading to groundbreaking disease-modifying therapies for Alzheimer's disease. The development of Lecanemab (Leqembi), a monoclonal antibody targeting amyloid plaques, offers a new option to slow disease progression. The program's focu

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