Adverse effects - PowerPoint PPT Presentation

The study compares the efficacy of ticagrelor monotherapy after less than 1 month of dual anti-platelet therapy (DAPT) to 12-month ticagrelor-based DAPT in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) with drug-eluting stent implantation. The aim is

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The concept of severity assessment in adverse drug reactions (ADRs) categorizes the intensity of medical events into mild, moderate, severe, or lethal categories based on the required management steps. Various classification systems such as Karch and Lasagna, as well as modified Hartwig's and Siegel

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This training package focuses on the safety monitoring and management of active tuberculosis drugs, specifically emphasizing causality assessment in determining adverse reactions. Participants will learn about assessing the likelihood of TB medicines causing adverse events, attributing relationships

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This data compilation covers the reporting trends, breakdown of reports, components issued, and specific types of adverse transfusion reactions experienced within the National Healthcare Organization (NHO) from 2019 to 2022. The information includes statistics on Serious Adverse Events (SAE), Seriou

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Adverse Events Following Immunization (AEFI) are medical incidents that occur after immunization, potentially caused by the vaccine, leading to unfavorable symptoms. Pharmacovigilance plays a crucial role in detecting, assessing, and preventing these events. AEFI can impact immunization programs at

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Significant delays affected the compilation of NSFAS Annual Financial Statements for 2021/22, leading to an adverse audit opinion due to material misstatements and limitations in various financial areas. The report highlights issues with amounts owed, receivables, bursaries, cash flows, irregular ex

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This presentation covers the identification, recording, and reporting of adverse events in clinical trials conducted by University of Edinburgh and/or NHS Lothian. It includes definitions, examples of adverse event recording, SAE form completion, and common mistakes. AEs can range from minor issues

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Study investigates the association between renal and cerebral near-infrared spectroscopy (NIRS) values and low cardiac output syndrome in single ventricle patients post Stage I palliation. Data from infants who underwent surgery between 2010-2019 is analyzed to determine correlations with adverse ou

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Adverse Childhood Experiences (ACEs) encompass a wide range of traumatic events during childhood that can have long-lasting effects on individuals. These experiences, such as abuse, neglect, and family issues, can significantly increase the risk of developing harmful behaviors and health conditions

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Toxicology is the study of adverse effects of chemicals on living organisms. It assesses probability of occurrence, quantitatively and qualitatively analyzing toxic effects. Toxicants are agents causing harmful responses in biological systems. Environmental toxicology focuses on pollutants' effects

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Explore the concept of interaction effects in composite-based structural equation modeling (SEM) through topics like the logic of interaction, estimating effects, multigroup analysis, and visualizing effects. Learn about moderators, their role in relationships between variables, and techniques for a

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Adverse drug reactions resulting from medication errors are a significant concern faced by pharmacovigilance centers. This content discusses the importance of this problem, contributing factors, the relevance to pharmacovigilance centers, and strategies for managing medication errors. It highlights

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The Bureau of EMS and Trauma System offers an online platform that allows the public to search for Emergency Medical Care Technicians (EMCT) by name or certification number. The system provides access to EMCT profiles, including information such as certification status, level, issuance and expiratio

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Individual trauma and adverse childhood experiences can have lasting effects on mental, physical, social, and emotional well-being. The Trauma-Informed Care Implementation Resource Center provides valuable insights on defining trauma, examples of traumatic events, prevalence statistics, and types of

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The Wisconsin Healthcare-Associated Infections in LTC Coalition provides guidelines on when to test and submit urine specimens for testing in long-term care facilities. The focus is on reducing unnecessary urine testing, introducing tools like the UTI Stoplight Tool and the When To Test-Nursing Tool

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Safety in research is crucial for protecting participants. This content covers key definitions, safety reporting responsibilities, regulatory guidelines, adverse event monitoring, and definitions related to adverse events in clinical trials. Understanding these aspects is essential for safeguarding

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Near-infrared spectroscopy (NIRS) has been studied in infants after Stage I palliation surgery to assess its association with low cardiac output and adverse outcomes. This retrospective study investigated postoperative cerebral and renal NIRS values in infants with single ventricle physiology. Resul

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The CLEAR Trial is a 2x2 factorial randomized trial evaluating the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the trial focuses on clinical and c

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This presentation by Ramy Abdelrahman, MD, delves into safety considerations, regulatory definitions, and practical responsibilities in drug evaluation. It covers adverse events, suspected adverse reactions, and reporting responsibilities for investigators and sponsors. The content emphasizes making

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Training session on Notice of Adverse Benefit Determination (NOABD) requirements and templates, including types of NOABDs and steps to complete them. Learn background, purpose, and responsibilities related to issuing NOABDs for Fresno County Mental Health Plan providers.

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Aircraft banking and turning involve rolling the aircraft to a predetermined angle of bank while maintaining performance and balance for level, climbing, or descending flight to achieve a predetermined heading. The primary methods for banking include using ailerons to turn the airplane, rudder to ba

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Learn how to execute medium turns in flight training, changing direction through 360 degrees at a constant rate while maintaining altitude and balance. Understand the principles of lift, adverse yaw, and overbanking performance involved in medium turns, along with techniques to reduce adverse yaw an

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This detailed content covers the importance of reporting adverse information regarding cleared employees in national security settings. It outlines the impact of adverse information on security clearances, the 13 adjudicative guidelines used in determining eligibility for sensitive duties, NISPOM re

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The comparison between Etravirine (ETR) and Efavirenz (EFV) in the SENSE Study showed differences in neuropsychiatric adverse events, treatment response, and patient characteristics. ETR with 2 NRTIs resulted in fewer drug-related adverse events than EFV with 2 NRTIs. ETR also showed better response

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This content covers driver responsibilities in adverse conditions, focusing on topics such as visibility, extreme weather, protecting occupants, roadway technology, and traction loss concerns. Important information is provided on headlight alignment, speed considerations, and nighttime precautionary

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Post-market surveillance of medical devices in Indonesia is overseen by the Surveillance Directorate of Medical Device and Household Health Supplies. Manufacturers must adhere to ASEAN guidelines and report adverse events through online systems. The country has specific regulations and requirements

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Effective management of pain, sedation, and delirium is essential in critical care settings to optimize patient comfort, facilitate recovery, and ensure better outcomes. The goal is to control pain adequately, minimize sedative use, and address indications for analgesia and sedatives while being min

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Iodine is essential for thyroid hormone synthesis, crucial for neurological development in utero and early life. Adequate iodine levels prevent adverse effects like decreased IQ, goiter, hypothyroidism, and hyperthyroidism. Mild to moderate iodine deficiency in pregnant women can have adverse outcom

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Guidelines for reporting adverse reactions in Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU), including definitions of Adverse Reactions (AR), Serious Adverse Reactions (SAR), Adverse Events (AE), Serious Adverse Events (SAE), SARs in SUP-ICU, and SUSARs. Specific conditions considere

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This study delves into the lasting impact of resolving distressed banks on the economy, showcasing significant compliance with regulatory thresholds and persistent adverse effects on local economies post-resolution. Findings suggest a notable drop in employment and establishments, with effects inten

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Yellow fever vaccination can lead to severe adverse reactions like anaphylaxis, neurotropic disease, and viscerotropic disease. These reactions can range from immediate hypersensitivity to rare but serious outcomes such as meningitis and multiple system organ failure. The mortality rate associated w

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The study evaluates the efficacy and toxicity of carboplatin in treating macroscopic non-osseous sarcomas in dogs. The research focuses on soft tissue sarcomas (STS) and mesenchymal tumors, exploring carboplatin's limitations, response rates, and toxicity profiles. Aimed at determining the drug's ef

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Targeted clinical investigation plays a crucial role in pharmacovigilance by further evaluating significant risks identified in pre-approval clinical trials. This involves conducting pharmacokinetic and pharmacodynamic studies, genetic testing, interaction studies, and large simplified trials to ass

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The Adverse Outcome Pathway (AOP) for Skin Sensitisation provides a mechanistic framework linking Molecular Initiating Events (MIE) to Adverse Outcomes (AO) through Key Events (KE) and Key Event Relationships (KER). AOPs offer a transparent justification for toxicological predictions and play a vita

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Explore the significance of adverse event reporting in clinical research, including definitions of adverse events (AEs) and serious adverse events (SAEs), as well as unanticipated problems (UAPs). Learn about the responsibilities of Investigators, Clinical Research Coordinators (CRCs), and Sponsors

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Narcotic analgesics, such as opiates and opioids derived from opium, interact with specific opioid receptors in the body to produce analgesic effects. Different opioid receptors have varying effects, with mu (MOP) being a good analgesic but with adverse effects, delta (DOP) and kappa (KOP) have nuan

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Toxicology is the study of the adverse effects of chemicals on living organisms, involving xenobiotics and poisonous substances. Toxicologists examine the nature of these effects, testing in lab animals for measures of toxicity such as mortality, teratogenicity, carcinogenicity, and mutagenicity. Ke

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CNS stimulants are drugs that primarily act on the central nervous system, with two main groups being psychomotor stimulants and hallucinogens. Common examples include caffeine, theophylline, and nicotine. These stimulants can have various effects on the body, such as increasing alertness, heart rat

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This study led by Dr. Robert Silbergleit focuses on adverse events in brain oxygen optimization for severe Traumatic Brain Injury (TBI) patients. It outlines key points for reporting adverse events, discusses relatedness algorithms, and presents scenarios to analyze adverse events occurrence post-en

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Side effects of medications in the acute setting can manifest as impairments in various body systems, including integumentary, musculoskeletal, cardiovascular/pulmonary, and neuromuscular systems. Factors influencing adverse drug events include pharmacokinetics, drug interactions, and patient-specif

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