Understanding Nuclear Medicine Radiotracers Distribution

Slide Note

Explore the distribution and physical properties of radiotracers in nuclear medicine, presented in an engaging format with questions and images related to diagnostic imaging and PET scans. Dive into the world of nuclear medicine with insights from experts in the field.

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Nuclear Medicine Radiotracers: Distribution and Physical Properties PART 2 Jacob Dubroff MD PhD Jennifer Schroeder, MD

Nuclear Medicine Jeopardy PET peeves I NM Don't know much biology 10 If you are doing this at home, the answers are in the slide notes, but the links on the main page only work in presentation mode. 10 10 20 20 20 30 30 30 The purple arrow at the bottom on the picture slides will take you back to this page 40 40 40 50 50 50 100 100 100

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Positive Negative

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Insert Text for Question Category 4 10 points This is the reason why you have to be careful about SUV measurements of inferior lung lesions and hepatic dome lesions. It is also why CT done for the PET is done at quiet breathing so that tidal volume is more representative of those occurring during PET acquisition. PET acquisition is too long to do breath hold.

Which is the NAC images?

How to treat/decrease brown fat (4Bs): blanket benzo beta blockers brown fat diet- aka ketogenic

Name two indications for an FDG PET of the Brain

Insert Text for Question Category 4 50 points 1st FDG-PET/CT only 1 week later 1 Week 2nd FDG-PET/CT Basic FDG PET diet prep: NPO preferentially for 6 hours before hand, at least 4 hours. No short acting insulin for 4 hours before.

NPO preferentially for 6 hours before hand, at least 4 hours no short acting insulin for 4 hours before hand Cardiac Nuclear Medicine Imaging Techniques are principally used to demonstrate these types of defects.

Please name a SPECT Cardiac Tracer Tc99m sestamibi Tc99m tetrofosmin Thallium 201

Positive scan Insert Text for Question Category 5 30 points Negative scan

Please name a PET Cardiac Tracer F18 FDG Rubidium 82 chloride Oxygen 15 water Nitrogen 13 ammonia

FDG Cardiac PET can be used to Demonstrate this. which PET is FDG, top or bottom row? Why?

This is a POST therapy SPECT Yttrium 90 with half life of 64 hours

What is the MeV of F-18?

What is stochastic effect? Effects that occur by chance and which may occur without a threshold level of dose, whose probability is proportional to the dose and whose severity is independent of the dose. In the context of radiation protection, the main stochastic effect is cancer.

What is Linear Energy Transfer LET: the amount of energy transferred per unit length traveled Which type of radiation has the highest LET?

What is the most radiation sensitive phase of the cell cycle? M then G2>G1>S cell sensitivity is also based on reproductive activity (parallel) and differentiation (inverse)

What molecules act as modulators of the effects of indirect radiation? Water we are bags of water with tiny bit of DNA-most radiation act on water which then affects DNA, aka the indirect What potentiates this process?