Understanding Acute Liver Disorders: Causes, Presentations, and Management
Acute liver disorders can have various causes such as drugs, viruses, ischemia, autoimmune conditions, and more. The presentations of acute liver disease can include abnormal liver tests, jaundice, liver impairment, and even liver failure. Management involves removing and treating the underlying cause, monitoring and support, with outcomes that usually resolve but can occasionally lead to death or the need for a liver transplant.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. Download presentation by click this link. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
E N D
Presentation Transcript
Acute Liver Disorders Will Gelson Consultant Hepatologist Addenbrooke s Hospital April 2020
Principles Causes Presentations Management Prognosis Principle of acute liver disease Insult Normal liver Liver injury Inflammation (hepatitis) Necrosis
Principles Causes Presentations Management Prognosis Causes of acute liver disease Insult Normal liver Drugs (paracetamol) Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Liver injury Inflammation (hepatitis) Necrosis
Principles Causes Presentations Management Prognosis Presentations of acute liver disease Abnormal liver tests Liver enzymes, jaundice Liver Injury Liver impairment Hyperacute Enceph < 1/52 Liver failure Acute 1-4/52 Subacute 4-24/52
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of acute liver disease Remove and treat cause Paracetamol Viruses Ischaemia Autoimmune Budd chiari Wilson s disease Monitor/support Usually resolves Occasionally leads to death or liver transplantation
Principles Causes Presentations Management Prognosis Management of Acute Liver Failure Acute liver failure is a multisystem disorder Na balance ICP measures Fluid balance Inotropes Fluid balance Haemofiltration Electrolyte correction Early haemfiltration Liver transplantation Glucose Ventilation Blood products Broad spectrum antimicrobials Fluid balance Inotropes https://easternliver.net
Principles Causes Presentations Management Prognosis Progosis of Acute Liver Failure Creatinine, INR, bilirubin, encephalopathy, pH, lactic acidosis http://odt.nhs.uk/pdf/liver_selection_policy.pdf
Principles Causes Presentations Management Prognosis Summary Principles Clinical presentations Causes Management Prognosis
Principles Causes Presentations Management Prognosis Questions and Wiki william.gelson@addenbrookes.nhs.uk Hepatology wiki Power point files https://easternliver.net
