Understanding Uric Acid: Causes, Symptoms, and Testing
Learn about uric acid, its role in the body, normal range in blood plasma, conditions like hyperurecemia and hypourecemia, clinical significance, and reasons for uric acid testing. Discover the importance of monitoring uric acid levels for conditions like gout, renal failure, and chemotherapy outcomes.
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Presentation Transcript
Uric acid Uric acid
Introduction Introduction Uric breakdown of nucleic acids and is an end product of purine metabolism. Uric acid is transported by the blood from the liver to the kidney, where it is filtered. Renal excretion accounts for 75% of uric acid elimination; the remainder of uric acid passes into the GI tract. acid is formed from the
Normal range Normal range In human blood plasma Female: 2.4-6.1 mg/dl (140-360 mol/L) Male: 3.4-7.2 mg/dl (200-430 mol/L)
Hyperurecemia Hyperurecemia Causes of hyperurecemia Urate Pool High intake of dietary purine Hereditary reasons Reduced excretion by kidney Drugs e.g. thiazide diuretics Fasting or rapid weight loss can temporary elevate uric acid level
Hypourecemia Hypourecemia is less common than hyperuricemia and is usually secondary to severe liver disease or defective tubular reabsorption, as in Fanconi syndrome.
Clinical significance Clinical significance Disease states with increased plasma uric acid Gout (increased serum levels of uric acid lead to formation of monosodium urate crystals around the joints) Increased catabolism of nucleic acids Renal disease
Why it is done Why it is done Uric acid test is useful to Assess for gout Monitor patients with renal failure and see if kidney stone may be caused by high uric acid level Monitor if uric acid levels are too high after chemotherapy or radiation See if medicine that decreases uric acid level is working
