Understanding the Effects of Methamphetamine and Cocaine

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Explore the key differences between cocaine and methamphetamine, the role of dopamine in the brain, the effects of dopamine imbalance, and the impact of stimulant drugs like shabu/cocaine on dopamine levels over time. Learn about the craving, use, depression, and addiction cycle associated with these substances, as well as the various routes of administration and the popularity of shabu among users. Gain insights into how these drugs affect the brain and behavior.


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  1. Psycho-Education for Patients and Family Members Session 5: Methamphetamine and Cocaine (1) 4-1

  2. Differences Between Cocaine and Methamphetamine Cocaine effects: 1 to 2 hours. Methamphetamine effects: 8 to 12 hours. 4-2

  3. Dopamine Is a chemical that is always present in the brain Plays an important role in - Body movement - Thinking - Motivation and reward - Pleasure responses 4-3

  4. Example of Dopamines Effect Eating Dopamine Pleasure Motivation (desire) to eat again when hungry 4-4

  5. Dopamine Imbalance Too much dopamine causes nervousness, irritability, aggressiveness, paranoia, and bizarre thoughts. Too little dopamine causes low mood, fatigue, tremors, and problems with muscle control. 4-5

  6. Dopamine and Stimulant Drugs Shabu/cocaine Use Dopamine Mostly Pleasure + Some Negative Effects 4-6

  7. Dopamine and Stimulant Use Over Time Damaged dopamine system Shabu/cocaine Use Over Time Some Pleasure + Many Negative Effects 4-7

  8. Craving Use Depression Addiction Cycle 4-8

  9. Route of Administration Available forms of Shabu/cocaine: Injected Smoked Snorted How a drug is taken influences: How quickly it produces an effect The strength of the drug s effects, both positive and negative The kind of negative effects a person will experience 4-9

  10. Methamphetamine (Shabu) 4-10

  11. Popularity of Shabu Shabu users in 2015 were 0.86 million or 1.1% of the population aged 10-69 years. 96% of the patients admitted to the DOH- TRCs were Shabu users in 2017. 4-11

  12. Question: What are some of the immediate effects of Shabu? To your feelings and mental status To your body 1-12

  13. Immediate Psychological Effects Increased euphoria Increased alertness or wakefulness Increased feelings of strength/energy Increased feelings of invulnerability Increased feelings of confidence/competence Increased feelings of sexual desire Decreased boredom, loneliness, and shyness 4-13

  14. Immediate Physical Effects Increase of: Heart rate Blood pressure Pupil size Breathing rate Sound sensitivity Body temperature Decrease of: Appetite Sleep Reaction time 4-14

  15. Toxic Effects Methamphetamine can cause serious psychological and physical damage. Negative effects begin fairly soon. 4-15

  16. Question: What are some of the chronic or long-term effects of Shabu? To your feelings and mental status To your body 1-16

  17. Chronic Psychological Effects Confusion Loss of ability to concentrate and organize information Loss of ability to feel pleasure without the drug Paranoia Insomnia and fatigue Mood swings Irritability and anger Depression Anxiety and panic disorder Reckless, unprotected sexual behavior 4-17

  18. Severe Psychological Effects Hallucinations Severe depression that can lead to suicidal thoughts or attempts Episodes of sudden, violent behavior Severe memory loss that may be permanent 4-18

  19. Chronic Physical Effects Tremor Weakness Dry mouth Weight loss/malnutrition Increased sweating Oily skin Sores Headaches Severe problems with teeth and gums 4-19

  20. Severe Physical Effects Seizures Damaged blood vessels in the brain/stroke Damaged brain cells Irregular heartbeat/sudden death Heart attack or chronic heart problems Kidney failure Liver failure Tweaking Infected skin sores 4-20

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