Understanding Quinoline Alkaloids in Ruta graveolens for Medicinal Purposes

Ruta graveolens, commonly known as Rue, contains quinoline alkaloids and other active constituents with medicinal properties. This plant is used in the treatment of various inflammatory conditions, ulcers, arthritis, and more. However, there are cautionary notes for specific groups such as pregnant women and patients with certain disorders. The isolation procedure of alkaloids from Ruta involves specific extraction methods for further analysis.

• Quinoline Alkaloids
• Ruta graveolens
• Medicinal Uses
• Alkaloid Isolation
• Phytochemistry

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1. Quinoline alkaloid Ph Faten Essam MSc pharmacy science

2. Quinolones Is a heterocyclic aromatic compound with chemical formula C9H7N Its slightly soluble in cold water but dissolve readily soluble in hot water and most organic solvents. Common example of plant contain quinoline alkaloid Cinchona and Ruta

3. Ruta Scientific name : Ruta graveolens Family Rutaceae Ruta is commonly known as Rue is a genus of ever green subshrub (20-60cm in tall ) , its grown in garden all over the world , it cultivated for its medicinal properties and insect repellent properties

4. Active constituents Ruta contain many important active ingredient include : Glycoside Rutin Quinoline alkaloids Tannins Oils Sterols

5. Medicinal uses of Ruta Ruta documented therapeutic uses include the treatment of inflammatory conditions, eczema, ulcers, arthritis, fibromyalgia, antidote for venoms, It also have (anthelmintic , antispasmodic , carminative ,emetic and expectorant ) effect

6. Caution and contraindications Pregnant and lactating women GIT disorder Patient with renal disorders Patient with liver disease

7. Plant used in this lab Ruta graveolens Part used whole plant

8. Procedure 1- add 100 ml of hexane to 10 gm of plant . (why ?)

9. 2- Filter plant material 3-then use method 2 of alkaloid isolation which include : a. To the marc add 100 ml of dilute acidified alcohol and mix for 10 min. b. Filter the plant material and collect the extract

10. c- Take 5 ml of extract in s. p and add 5 ml of chloroform to it then shake well and let stand d-Now take the aq layer and add sodium bicarbonate ????

11. e-Add 5 ml of chloroform to the mixture and collect the organic layer

12. Now you get alkaloid as.????

13. Detections Wagner's test Potassium permanganate + extract 1-reagent color (purple) disappear 2- brown precipitate will form