Understanding Bulk Forming Laxatives for Improved Digestive Health
Bulk forming laxatives are effective in relieving constipation by increasing fecal mass and stimulating peristalsis. They work by forming a gel-like substance in the intestines, keeping stool soft and hydrated. Adequate fluid intake is important while using these laxatives to avoid intestinal obstruction. Their full effect may take up to a few days to be noticeable. Learn more about the benefits and considerations of bulk forming laxatives in managing constipation.
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Lab 3 IN VITRO EVALUATION OF BULK FORMING LAXATIVES
Introduction Introduction A laxative is a medicine that loosen the bowel contents and encourages evacuation. Laxatives taken regularly tend to deprive the colon of its natural muscle tone . Simple constipation is usually relieved by increasing the intake of dietary fiber.
Laxatives should be generally avoided except where: 1. Straining exacerbates a condition such as angina or increases the risk of rectal bleeding as in hemorrhoids. 2. Laxatives are also of value constipation. 3. For the repulsion of parasites after anthelmintic treatment. 4. To clear the alimentary tract before surgery and radiological procedures. in drug induced
Laxatives have been divided into four main Laxatives have been divided into four main groups: groups: Stimulant laxatives (irritant) Fecal softeners(emollients or wetting) Osmotic laxatives Bulk forming laxatives
Stimulant laxatives (irritants):These act by increasing intestinal motility . The most commonly used stimulant laxatives are :castor oil,cascara and senna . Fecal softeners(emollient or wetting):They act by lubricating the feces. For example liquid paraffin or by softening the feces for example sodium dioctyl sodium sulfosuccinate . This may cause a sufficient rectal stimulation to promote a bowel action . These drugs are useful in management of hemorrhoids and anal fissure. Osmotic laxatives: These act by maintaining the volume of fluid in the bowel by osmosis .e.g. magnesium carbonate ,magnesium hydroxide and magnesium sulfate. 1. 2. 3.
Bulk forming laxatives: These relieve constipation by increasing fecal mass which stimulate peristalsis . These include various natural and polysaccharides and cellulose derivatives that dissolve or swell in water to form an emollient gel or viscous solution that maintain the feces soft and hydrated. In addition ,this indigestible residue may stimulate peristalsis reflexly . 4. semi synthetic
The laxative effect of the bulk forming agent is usually apparent within 12-24 hours ,but their full effect may not be achieved until the 2ndor 3rdday of medication . Adequate fluid intake may be maintained to avoid intestinal obstruction. The efficiency of the bulk forming agent depends on its water retaining properties( whether it is good or poor).
Indications of bulk forming agents: Indications of bulk forming agents: Constipation caused by inadequate fiber intake. Anal fissure Hemorrhoids
Cautions Cautions Adequate fluid intake should be maintained Caution in ulcerative colitis(inflammation of colon)
Contraindications : Contraindications : Intestinal obstruction colonic atony absence or lack of normal tone
Questions : Why is an evaluation carried out in neutral ,acidic and alkaline mdia ? What are the ideal swelling properties of bulk forming laxatives?
