Understanding Blood Clotting Mechanism and Factors
Explore the intriguing process of blood clotting, also known as coagulation, and learn about the intricate interplay of factors and pathways involved. Discover how fibrinogen transforms into fibrin, leading to the formation of a stable clot. Dive into the roles of key factors like thrombin, thromboplastin, calcium, and more in this essential biological process.
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Presentation Transcript
The Clotting of Blood The normal human blood when shed , losses its fluidity in 5 to 6 min and sets into a semi solid jelly. This phenomenon is called clotting or coagulation. According to Howell Theory of blood coagulation , the change of fibrinogen into fibrin is caused by thrombin which in fluid exists as prothrombin. The conversion of prothrombin to thrombin depends on the action of thromboplasin and calcium.
Mechanism clot formation involves interplay of two kinds of enzymatic pathways : Intrinsic and Extrinsic pathway that coverage on a common pathway resulting in the production of fibrin clot.
Blood Clotting Factors I Fibrinogen IIProthrombin III Thromboplastin IV calcium V Proaccelerin VIIProconvertin VIII Antiheamophilic globulin IX Christmas Factor
X Stuart Factor XI plasma thromboplasin antecedent(PTA) XII Hageman factor XIII Fibrin Stabilising factor
