The Hair Growth Cycle and Structure
H
a
i
r
a
n
d
H
a
i
r
G
r
o
w
t
h
C
y
c
l
e
B.Pharm III rd Year, Sem I
Cosmetic Science
Dr. IVL Padmini
Department of Pharmaceutics
Department of Pharmaceutics, MLRIP
1
W
h
a
t
i
s
h
a
i
r
?
•
Hair
is
a
protein
filament
that
grows
from
follicles
found
in
the
dermis,
or
skin.
•
It
is
one
of
the
defining
characteristics
of mammals.
•
It
is
an
important
biomaterial
primarily
composed
of
protein,
notably
keratin.
Department of Pharmaceutics, MLRIP
2
T
h
e
m
a
i
n
f
u
n
c
t
i
o
n
s
o
f
H
a
i
r
•
Thermo
regulation
•
Protection
•
Facilitation
for
evaporation
of
perspiration
•
Heat
insulation
on
head
Department of Pharmaceutics, MLRIP
3
S
t
r
u
c
t
u
r
e
o
f
H
a
i
r
Department of Pharmaceutics, MLRIP
4
A
n
a
t
o
m
y
o
f
H
a
i
r
Department of Pharmaceutics, MLRIP
5
L
a
y
e
r
s
o
f
H
a
i
r
1.
Medulla
2.
Cortex
3.
Cuticle
Department of Pharmaceutics, MLRIP
6
Medulla
o
Centre
layer
of
hair
shaft
o
Not
always
present
,
can
be
continuous
broken
o
Made
up
of
large
loosely
connected
cells
o
No
known
function
Department of Pharmaceutics, MLRIP
7
Cor
t
e
x
o
Largest
and
most
important
layer
of the
hairshaft
o
Determines
the
texture
of
the
hair
o
Contains
melanin
and
moisture
Department of Pharmaceutics, MLRIP
8
Cuticle
o
The
outer
layer
of the
hair
shaft
o
Made
up
of clear
overlapping
scales
o
Contains
no
melanin
Department of Pharmaceutics, MLRIP
9
H
a
i
r
g
r
o
w
t
h
c
y
c
l
e
•
Hair
development
is
a
continuous
cyclic
process
and
all
mature
follicles
go
through
a
growth
cycle
consisting
of
growth
(anagen),
regression
(catagen),
rest
(telogen)
and
shedding
(exogen)
phases.
•
The
duration
of the
phases
changes
based
on
the
location
of
the
hair
and
also
personal
nutritional
and
hormonal
status
and
age.
Department of Pharmaceutics, MLRIP
10
Department of Pharmaceutics, MLRIP
11
Anagen
•
The
anagen
is
the
active
growth
phase
in
which
the
follicle
enlarges
and
takes
the
original
shape
and
the
hair
fiber
is
produced.
•
Almost
85–90%
of
all
scalp
hairs
are
in
anagen.
•
Mitosis
is
occurring
•
Hair
grows
between
1
to
1.5
cm
per
month.
•
Hair
bulb
is
round
and
full
&
contains
melanin
in
it.
Department of Pharmaceutics, MLRIP
12
Catagen
•
At
the
end
of
anagen,
mitotic
activity
of
the
matrix
cells
is
diminished
and
the
follicle
enters
a
highly
controlled
involutionary
phase
known
as
catagen.
•
Catagen
lasts
approximately
2
weeks
in
humans,
regardless
of the
site
and
follicle
type.
•
Transition
stage
•
Mitosis
stops
Department of Pharmaceutics, MLRIP
13
Telogen
•
The
telogen
stage
is
defined
as the
duration
between
the
completion
of
follicular
regression
and
the
onset
of the
next
anagen
phase.
•
Telogen
stage
lasts
for
2–3
months.
•
Approximately
10–15%
of
all
hair
is
in
telogen
stage.
•
Hairs
fall
out
,
approx
50-80
hairs
per
day
are
lost.
Department of Pharmaceutics, MLRIP
14
S
H
A
M
P
O
O
S
A
N
D
H
A
I
R
R
E
S
T
O
R
I
N
G
A
G
E
N
T
S
•
A
Shampoo
is
a
preparation
of
a
surfactant
in a
suitable
form
–
liquid,
solid
or
powder
which
when
used
under
the
specialized
conditions
will
remove
surface
grease,
dirt
and
skin
debris
from
the
hair shaft
and
scalp
without
adversely
affecting
the
user.
o
Ideal
properties
•
It
should
produce
good
amount
of
foam.
•
It
should be
easily
removed
on
rinsing
with
water.
•
It
should
impart
a
pleasant
fragrance
to
the
hair.
•
It
should
not
cause
any
side
affects
or
irritation
to
the
skin
or
eye.
•
It
should
be
effectively
or
completely
remove
dust
or
soil.
•
It
should
not
make
the
hand
rough.
Department of Pharmaceutics, MLRIP
15
F
o
r
m
u
l
a
t
i
o
n
O
f
D
i
f
f
e
r
e
n
t
T
y
p
e
s
O
f
S
h
a
m
p
o
o
1.
Powder
Shampoo
2.
Lotion
shampoo
Department of Pharmaceutics, MLRIP
17
3.
Liquid
shampoo
Department of Pharmaceutics, MLRIP
18
4.
Anti
dandruff shampoo
Department of Pharmaceutics, MLRIP
19
5.
Conditioning
shampoo
Department of Pharmaceutics, MLRIP
20
6.
Herbal
shampoo
Department of Pharmaceutics, MLRIP
21
7.
Mintop
10%
Lotion
Department of Pharmaceutics, MLRIP
22
8.
Nizoral
Shampoo
1%
Ketaconazole
………………..1%
Acrylic acid
polymer
Butylated
hydroxyl
toluene
Cocamide
MEA
FD
&
C
BLUE
#1
Fragrance
Glycol
distearate
Polyquaternium
-7
Quaternium
-15
NaCl
Sodium
cocayl
sarcosinate
NaoH
SLS
Tetrasodium
EDTA
Water
Department of Pharmaceutics, MLRIP
23
Hair is a protein filament that grows from follicles in the skin, playing essential roles in thermal regulation, protection, and facilitating perspiration evaporation. The hair consists of layers like the medulla, cortex, and cuticle, each with specific functions. Hair growth follows a cyclic process involving phases of growth, regression, rest, and shedding, influenced by various factors like location, nutrition, hormones, and age.
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Presentation Transcript
Hair Hair and Growth Cycle and Hair Hair Growth Cycle Dr. IVL Padmini Department of Pharmaceutics B.Pharm III rd Year, Sem I Cosmetic Science Department of Pharmaceutics, MLRIP 1
What Whatis is hair? hair? Hair is a protein filament that grows from follicles found in the dermis, or skin. It is one of the defining characteristics of mammals. It is an important biomaterial primarily composed of protein, notably keratin. Department of Pharmaceutics, MLRIP 2
The Themain mainfunctions functions of of Hair Hair Thermo regulation Protection Facilitation for evaporation of perspiration Heat insulation on head Department of Pharmaceutics, MLRIP 3
Structure Structureof ofHair Hair Department of Pharmaceutics, MLRIP 4
Anatomy Anatomy of of Hair Hair Department of Pharmaceutics, MLRIP 5
Layers Layersof ofHair Hair 1. Medulla 2. Cortex 3. Cuticle Department of Pharmaceutics, MLRIP 6
Medulla oCentre layer of hair shaft oNot always present , can be continuous broken oMade up of large loosely connected cells oNo known function Department of Pharmaceutics, MLRIP 7
Cortex oLargest and most important layer of the hairshaft oDetermines the texture of the hair oContains melanin and moisture Department of Pharmaceutics, MLRIP 8
Cuticle oThe outer layer of the hair shaft oMade up of clear overlapping scales oContains no melanin Department of Pharmaceutics, MLRIP 9
Hair Hairgrowth growthcycle cycle Hair development is a continuous cyclic process and all mature follicles go through a growth cycle consisting of growth (anagen), regression (catagen), rest (telogen) and shedding (exogen) phases. The duration of the phases changes based on the location of the hair and also personal nutritional and hormonal status and age. Department of Pharmaceutics, MLRIP 10
Anagen The anagen is the active growth phase in which the follicle enlarges and takes the original shape and the hair fiber is produced. Almost 85 90% of all scalp hairs are in anagen. Mitosis is occurring Hair grows between 1 to 1.5 cm per month. Hair bulb is round and full & contains melanin in it. Department of Pharmaceutics, MLRIP 12
Catagen At the end of anagen, mitotic activity of the matrix cells is diminished and the follicle enters a highly controlled involutionary phase known as catagen. Catagen lasts approximately 2 weeks in humans, regardless of the site and follicle type. Transition stage Mitosis stops Department of Pharmaceutics, MLRIP 13
Telogen The telogen stage is defined as the duration between the completion of follicular regression and the onset of the next anagen phase. Telogen stage lasts for 2 3 months. Approximately 10 15% of all hair is in telogen stage. Hairs fall out , approx 50-80 hairs per day are lost. Department of Pharmaceutics, MLRIP 14
SHAMPOOS SHAMPOOSAND ANDHAIR HAIRRESTORING RESTORINGAGENTS AGENTS A Shampoo is a preparation of a surfactant in a suitable form liquid, solid or powder which when used under the specialized conditions will remove surface grease, dirt and skin debris from the hair shaft and scalp without adversely affecting the user. oIdeal properties It should produce good amount of foam. It should be easily removed on rinsingwith water. It should impart a pleasant fragranceto the hair. It should not cause any side affects or irritationto the skin or eye. It should be effectively or completely remove dust or soil. It should not make the hand rough. Department of Pharmaceutics, MLRIP 15
Formulation FormulationOf OfDifferent DifferentTypes TypesOf OfShampoo Shampoo 1. Powder Shampoo
2. Lotion shampoo Department of Pharmaceutics, MLRIP 17
3. Liquid shampoo Department of Pharmaceutics, MLRIP 18
4. Anti dandruff shampoo Department of Pharmaceutics, MLRIP 19
5. Conditioning shampoo Department of Pharmaceutics, MLRIP 20
6. Herbal shampoo Department of Pharmaceutics, MLRIP 21
7. Mintop 10% Lotion Department of Pharmaceutics, MLRIP 22
8. Nizoral Shampoo 1% Ketaconazole ..1% Acrylic acid polymer Butylated hydroxyl toluene Cocamide MEA FD & C BLUE #1 Fragrance Glycol distearate Polyquaternium-7 Quaternium-15 NaCl Sodium cocayl sarcosinate NaoH SLS Tetrasodium EDTA Water Department of Pharmaceutics, MLRIP 23
