Phase 2b Study on Cenicriviroc in NASH - CENTAUR Study
Randomized double-blind study on efficacy of Cenicriviroc in NASH patients with specific criteria including hepatic histologic improvement and no worsening of fibrosis. The primary endpoint at Year 1 focused on NAS improvement, with key secondary endpoints including fibrosis and steato-hepatitis improvement. Detailed baseline characteristics and study outcomes were presented, highlighting the potential of Cenicriviroc in treating NASH.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
You are allowed to download the files provided on this website for personal or commercial use, subject to the condition that they are used lawfully. All files are the property of their respective owners.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.
E N D
Presentation Transcript
Speaking the Future CALRG 2019 Ralph Mercer ralph.mercer@open.ac.uk 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 1
A Critical Futures Studies approach to the Technologies of Learning in Post Compulsory Education. Advocates a temporal turn from traditional Philosophy of Technology, to one of anticipatory responsibility through Critical Futures Studies. Technological habitus, recognizing the technological values, norms, beliefs and structures, have influence on individual agency and future imagery. Conceptual Framework Three foundational beliefs. 1st: Critical Futures Studies (as employed in this research) seeks to engage with the technological possibilities facing the future of post-compulsory education by examining the values and norms within individual narratives. 2nd: We need to employ new ways to examine the relationship between technology, the learner and the future of PCE, being accountable for the consequences of our choices. 3rd: The research argues for a new way to conceptualize the learner/technology relationship that recognizes that our technological habitus and agency impacts our ability to see possibilities for technology into the future. Provides a window into the habitus of technology, through examining the layers of human/technology relationships Causal Layered Analysis Exposes technological archetypes of narrative imagery: dystopic, liberal, radical and methodological Surfaces habits and beliefs as a means of understanding of one's own technological habitus and opens alternate ways of reflecting on the issues. Moves conversation away from prediction towards our relationship with the technologies of learning, opening new ways of conceptualizing the future of post-compulsory education. Mapping 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 2
Research Goals Identify the technological values and norms that influence the future of Post Compulsory education To provide a map of the phenomena Causal Layered Analysis The Social/Structural layer Litany Layer Metaphor/Myth Layer World-view Layer The second layer concerns itself with systemic issues related to social, technological, economic, environmental and political. What one hears, sees and talks, shaped by the trends that are politicized or sensationalized, within the news, media. The deep unquestioned, and often unconscious stories and archetypes that evoke our strongest emotions. The language of the narrative is more about imagery, targeting the heart not the mind of the individual. The layer explores the narratives at a stakeholder, organizational, professional or institutional level. Characterized by feelings of what can I do, nothing can be done, its just the way it is, and why doesn t someone do something. Policies, rules conventions and professions exist through this level Rarely challenging the existing paradigm, world views or myths. 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 3
Research Process Review of Existing Literature Research Goals Initially two groups identified as interview victims, Practitioners and Predictors 15 of ?? Interviews done and transcribed. 7 practitioners, 8 Predictors Preliminary scan completed using the methodology of Causal Layered Analysis Emerging Findings are interesting. Interviews Causal Layered Analysis Mapping the Probable future Exposing the possible futures 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 4
First pass of Causal Layered Analysis Causal layered analysis is concerned less with predicting a particular future and more with opening up the present and past to create alternative futures. Education is locked into a used future Majority claiming to be methodologists but appear to guided by determinist and instrumentalist beliefs The metaphor of the school house is unchallenged and unassailable Technology a tool to enhance not innovate No conversation about Bio, Trans or Centaur implications of future technology This distance allows us to question current social and technical practices. Emergent Findings Causal layered analysis (CLA) is a credible theoretical and methodological frameworks to understand educational futures as a subset of the broader technological transformation of society, environment and political processes. 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 5
Discussion? 21/02/2025 Ralph Mercer ralph.mercer@open.ac.uk 6
