Mammalian Kidney: Structure and Function Insights
Structure and Function of the
Mammalian Kidney
Tidbit: Grow the Gradient
Context
Intro Bio, Anatomy & Physiology, Toxicology,
Pharmacology, any course covering the kidney
3, 50-minute sessions
Learning Goals
•
Students will understand structure and function
of the mammalian kidney and how membrane
transport processes are intrinsically integrated
with kidney function.
•
Students will be able to associate the diversity in
structure and function of the mammalian kidney
in organisms that live in different habitats.
•
Students will elucidate the role of mammalian
kidney in disease and toxicology.
Learning Goals
•
Students will understand structure and function
of
the mammalian kidney and how membrane
transport processes are i
ntrinsically integrated
with kidney function.
•
Students will be able to associate the diversity in
structure and function of the mammalian kidney
in organisms that live in different habitats.
•
Students will elucidate the role of mammalian
kidney in disease and toxicology.
We chose this because…
…and this…
Reabsorption:
100% Glucose
Most salts
No Urea
Loop of Henle:
Countercurrent Multiplier
NaCl and water reabsorption
Urea reabsorption here only
Adds to medulla mosm/L
Urine is more concentrated than blood
Learning Objectives
•
Simulate
the movement of water and
sodium
at each
region of the Loop of Henle
•
Associate osmosis and active transport with
movement of water/solutes at each region of the
L
oop of Henle
•
Discuss
how the descending and ascending limbs of
the tubules maintain a concentration gradient
•
Predict the impact of the length of the Loop of Henle
on the magnitude of the salt gradient
•
Predict the length of the Loop of Henle in organisms
from different habitats
Students
already
can:
•
Define osmosis, active transport
•
Label the parts of a kidney
•
Label the parts of a nephron
We know they can because…
Pre-Assessment
Online pre-class quiz
OR
Clicker questions at beginning of class
Pre-Assessment
•
Questions to address:
–
osmosis
–
active transport
F
i
g
.
1
2
-
3
a
,
p
.
2
2
8
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y
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h
r
a
U
r
e
t
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r
(
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f
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)
Macro-scale anatomy
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Kidney anatomy
B
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Nephron
anatomy
From proximal
tubule
To distal tubule and
collecting duct
Loop of Henle
filtrate
Interstitial fluid
Descending limb
Ascending limb
Final labeling question
on pre-assessment
Example of an Animation of Filtrate Flow
and Membrane Transport Processes
From proximal
tubule
To distal tubule and
collecting duct
filtrate
Interstitial fluid
Descending
limb
:
Water
permeable only
Ascending
limb:
Water
IMpermeable
Your game board looks like:
N
a
A
c
t
i
v
e
T
r
a
n
s
p
o
r
t
Teaching Tidbit
Grow the Gradient
Your team’s job:
Use appropriate transport processes to establish
a concentration gradient in the kidney
Follow along as we familiarize you with the
rules.
Check in at each stopping point to make sure
you are on the right track.
Filtrate Pump
Rule 1: Move Filtrate 1 space
300
300
300
300
300
300
300
300
300
Filtrate Pump
Rule 1: Move 1 space;
Rule 2: Check Diagram!
1
400
400
400
200
200
200
400
400
400
Membrane Transport: sodium and water
Rules 3 and 4
1
Is there a gradient in the interstitial fluid?
300
400
400
200
200
400
300
400
400
Filtrate Pump
Rules 1 and 2
2
350
400
500
150
200
300
350
400
500
Membrane Transport: sodium and water
Rules 3 and 4
2
Is there a gradient in the interstitial fluid?
350
400
500
150
200
300
350
400
500
2
What would happen to the concentration
gradient if you continued the “game”?
300
600
1200
Na gradient
Loop of Henle and Water Conservation
A.
B.
Predict which Loop of Henle, A or B, would establish the
largest concentration gradient in the interstitial tissue?
Loop of Henle and Water Conservation
A.
B.
Predict which Loop of Henle, A or B, belongs to a desert rat?
?
Other
Post-
A
ssessment
•
Label the game board with:
–
osmosis, sodium transport pump, direction
of water and sodium movement
•
Write a reflection
•
Use strip sequence to order the
steps that
occur in the Loop of Henle
Diversity/Inclusion
•
Group activity
–
Students of different backgrounds, genders,
experience, etc working together
•
Peer – peer instruction
•
Facilitate learning in those that learn best in
different modalities:
–
reading, verbal, visual, kinesthetic
Learning Objectives
•
Simulate
the movement of water and
sodium
at each
region of the Loop of Henle
•
Associate osmosis and active transport with
movement of water/solutes at each region of the
L
oop of Henle
•
Discuss
how the descending and ascending limbs of
the tubules maintain a concentration gradient
•
Predict the impact of the length of the Loop of Henle
on the magnitude of the salt gradient
•
Predict the length of the Loop of Henle in organisms
from different habitats
Thank you!
Nike and Christov
Group 4
Group 7
Delve into the intricate workings of the mammalian kidney, exploring its diverse functions, membrane transport processes, and role in various habitats and diseases. Discover the fascinating mechanisms behind osmosis, active transport, and gradient maintenance.
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Presentation Transcript
Structure and Function of the Mammalian Kidney Tidbit: Grow the Gradient
Context Intro Bio, Anatomy & Physiology, Toxicology, Pharmacology, any course covering the kidney 3, 50-minute sessions
Learning Goals Students will understand structure and function of the mammalian kidney and how membrane transport processes are intrinsically integrated with kidney function. Students will be able to associate the diversity in structure and function of the mammalian kidney in organisms that live in different habitats. Students will elucidate the role of mammalian kidney in disease and toxicology.
Learning Goals Students will understand structure and function of the mammalian kidney and how membrane transport processes are intrinsically integrated with kidney function. Students will be able to associate the diversity in structure and function of the mammalian kidney in organisms that live in different habitats. Students will elucidate the role of mammalian kidney in disease and toxicology.
and this Reabsorption: 100% Glucose Most salts No Urea Urea reabsorption here only Adds to medulla mosm/L Loop of Henle: Countercurrent Multiplier NaCl and water reabsorption Urine is more concentrated than blood
Learning Objectives Simulate the movement of water and sodium at each region of the Loop of Henle Associate osmosis and active transport with movement of water/solutes at each region of the Loop of Henle Discuss how the descending and ascending limbs of the tubules maintain a concentration gradient Predict the impact of the length of the Loop of Henle on the magnitude of the salt gradient Predict the length of the Loop of Henle in organisms from different habitats
Students already can: Define osmosis, active transport Label the parts of a kidney Label the parts of a nephron We know they can because
Pre-Assessment Online pre-class quiz OR Clicker questions at beginning of class
Pre-Assessment Questions to address: osmosis active transport
Macro-scale anatomy Kidney (one of a pair) Ureter (one of a pair) Urinary Bladder Urethra Fig. 12-3a, p. 228
renal cortex renal medulla Kidney anatomy renal artery renal vein renal pelvis renal capsule ureter
proximal tubule distal tubule Bowman s capsule Nephron anatomy KIDNEY CORTEX KIDNEY MEDULLA loop of Henle collecting duct
Final labeling question on pre-assessment Loop of Henle Interstitial fluid To distal tubule and collecting duct filtrate From proximal tubule Descending limb Ascending limb
Example of an Animation of Filtrate Flow and Membrane Transport Processes
Your game board looks like: Interstitial fluid To distal tubule and collecting duct filtrate From proximal tubule Descending limb: Water permeable only Ascending limb: Water IMpermeable Na Active Transport
Grow the Gradient Your team s job: Use appropriate transport processes to establish a concentration gradient in the kidney Follow along as we familiarize you with the rules. Check in at each stopping point to make sure you are on the right track.
Filtrate Pump Rule 1: Move Filtrate 1 space
Filtrate Pump Rule 1: Move 1 space; Rule 2: Check Diagram! 300 300 300 300 300 300 300 300 300 1
Membrane Transport: sodium and water Rules 3 and 4 400 200 400 400 200 400 400 200 400 Is there a gradient in the interstitial fluid? 1
Filtrate Pump Rules 1 and 2 300 200 300 400 200 400 400 400 400 2
Membrane Transport: sodium and water Rules 3 and 4 350 150 350 400 200 400 500 300 500 Is there a gradient in the interstitial fluid? 2
What would happen to the concentration gradient if you continued the game ? 350 150 350 400 200 400 500 300 500 2
Na gradient 300 600 1200
Loop of Henle and Water Conservation B. A. Predict which Loop of Henle, A or B, would establish the largest concentration gradient in the interstitial tissue?
Loop of Henle and Water Conservation ? B. A. Predict which Loop of Henle, A or B, belongs to a desert rat?
Other Post-Assessment Label the game board with: osmosis, sodium transport pump, direction of water and sodium movement Write a reflection Use strip sequence to order the steps that occur in the Loop of Henle
Diversity/Inclusion Group activity Students of different backgrounds, genders, experience, etc working together Peer peer instruction Facilitate learning in those that learn best in different modalities: reading, verbal, visual, kinesthetic
Learning Objectives Simulate the movement of water and sodium at each region of the Loop of Henle Associate osmosis and active transport with movement of water/solutes at each region of the Loop of Henle Discuss how the descending and ascending limbs of the tubules maintain a concentration gradient Predict the impact of the length of the Loop of Henle on the magnitude of the salt gradient Predict the length of the Loop of Henle in organisms from different habitats
Thank you! Nike and Christov Group 4 Group 7
