Insights from the 26th European Meeting on Hypertension and Cardiovascular Protection
The SLEPT trial presented at the 26th European Meeting on Hypertension and Cardiovascular Protection in Paris explored the role of a sleep intervention in improving blood pressure. While the trial showed enhancements in sleep quality and psychosocial health, the primary outcome of better blood pressure control in mild hypertension cases at 8 weeks did not exhibit improvement. However, there is potential for benefits in patients with higher baseline blood pressure or longer follow-up periods. The study involved an Internet-based sleep intervention with online sleep hygiene education and cognitive behavioral therapy sessions over 6-8 weeks. Baseline characteristics of the study participants indicated average ages, vascular risk factors, and demographic distribution in the sample.
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26thEuropean Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 SLEPT Trial Examined Role of Sleep Intervention to Improve Blood Pressure From ESH 2016 | POS 4C: A. Power, MD HRB-Clinical Research Facility Galway, National University of Ireland, Galway, Ireland Infomedica Conference Coverage* of 26thEuropean Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 * Infomedica is an independent medical education provider that produces medical information to healthcare professionals through conference coverage and online educational programs and activities. Powered by Infomedica
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Overview Proof-of-concept trial demonstrated improvement in sleep quality and psychosocial health with a simple, low-cost, Internet-based sleep intervention No improvement in primary outcome of improved blood pressure control in population with mild hypertension at 8 weeks Potential of benefit in patients with higher baseline blood pressure or with longer follow-up cannot be excluded Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Overview Investigator-blinded study randomized 67 community- dwelling adults to Internet-based sleep intervention or no sleep intervention All participants received standard CV risk factor education Sleepio, the sleep intervention, consisted of online sleep- hygiene education and a standardized cognitive behavioral therapy (CBT) delivered in weekly sessions over 6-8 weeks by an animated virtual therapist, with automated reminders, and feedback, support, education Participants had self-reported sleep difficulty, defined as taking >30 minutes to go to sleep or waking up >1 time nightly for 3 months Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Baseline Characteristics in SLEPT Study Variable N (%) Standard care n=67 Sleep intervention n=67 Demographics Age, mean (SD), y 58.3 (11.9) 59.7 (9.9) Female 42 (62.7) 40 (59.7) Vascular risk factors Daytime SBP, mean (SD) 141.1 (11.3) 143.0 (11.7) Daytime DBP, mean (SD) 83.9 (9.5) 86.3 (8.6) Resting heart rate, mean 70.7 (12.5) 73.5 (10.6) BMI, mean (SD), kg/m2 27.1 (3.5) 27.0 (4.8) Dyslipidaemia 23 (34.3) 28 (41.8) Atrial fibrillation 2 (3.1) 4 (6.2) Peripheral vascular disease 1 (1.5) 0 (0) Current smoker 5 (7.5) 3 (4.5) BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure. Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Sleep and Psychosocial Outcomes Variable Mean (SD) Standard care (n=67) Sleep intervention (n=67) Difference in change (treatment vs. control) Week 0 Week 8 Week 0 Week 8 Estimate (95% CI) p- Change Change value +0.5 (1.7) 1.7 (4.1) 1.4 (2.6) 0.5 (3.7) 0.8 (3.3) +1.3 (1.8) 4.5 (4.4) 2.5 (3.1) 2.5 (5.6) 2.2 (4.5) 0.8 SCI 4.9 5.4 4.8 6.2 0.01 (0.2-1.4) 2.8 (1.3-4.4) 1.1 (0.1-2.2) 2.0 (0.3, 3.7) 1.4 (0.02-2.8) ISI 12.0 10.2 13.0 8.3 <0.001 PSQI 9.8 8.4 9.7 7.2 0.04 BDI 8.4 7.9 9.4 6.5 0.02 BAI 6.9 6.2 6.3 4.0 0.047 ASBP, ambulatory systolic blood pressure; ADBP, ambulatory diastolic blood pressure; NT, nighttime. Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Blood Pressure Outcomes in SLEPT Study Difference in change (treatment vs. control) Estimate (95% CI) Variable Mean (SD) Standard care (n=67) Sleep intervention (n=54) Week 0 Week 8 Week 0 Week 8 p- mmHg Change Change value Mean 24-h ASBP Mean 24-h ADBP Peak daytime SBP 0.8 (9.3) 1.5 (6.6) 0.9 (9.4) 0.6 (6.0) 0.1 136.8 136.2 138.0 136.9 0.95 (-3.4-3.2) -0.9 (-3.1-1.3) 82.5 81.2 83.5 83.1 0.43 2.2 (25.0) 2.4 (25.6) 0.2 164.2 162.4 168.8 165.5 0.97 (-8.7-9.1) Peak daytime DBP Peak NT SBP Peak NT DBP -0.1 (15.6) 0.1 (15.2) 0.2 102.9 103.3 107.0 107.5 0.94 (-5.2-5.6) 1.8 (18.5) 3.0 (15.7) -0.8 (21.3) -2.6 142.0 140.5 139.2 140.3 0.49 (-9.8-4.7) -4.4 (-10.3-1.4) 86.3 83.3 84.7 86.2 -1.4 (16.5) 0.14 ASBP, ambulatory systolic blood pressure; ADBP, ambulatory diastolic blood pressure; NT, nighttime. Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 SLEPT Trial Examined Role of Sleep Intervention to Improve Blood Pressure From ESH 2016 | POS 4C: A. Power, MD HRB-Clinical Research Facility Galway, National University of Ireland, Galway, Ireland Infomedica Conference Coverage* of 26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 * Infomedica is an independent medical education provider that produces medical information to healthcare professionals through conference coverage and online educational programs and activities. Powered by Infomedica
