Hazardous Drug Cleaning and Decontamination Training Overview
D
e
a
c
t
i
v
a
t
i
n
g
,
D
e
c
o
n
t
a
m
i
n
a
t
i
n
g
,
C
l
e
a
n
i
n
g
,
a
n
d
D
i
s
i
n
f
e
c
t
i
n
g
O
v
e
r
v
i
e
w
T
r
a
i
n
i
n
g
DATE
PLACE
Disclaimer: This presentation contains information on the general principles for safe handling of hazardous drugs. This presentation
cannot account for individual variation among facilities and cannot be considered inclusive of all proper methods of occupational
safety. It is the responsibility of the facility management and staff to determine the best course of occupational safety for
operations. The American Cancer Society and its partners assume no responsibility for any injury or damage to persons or property
arising out of or related to any use of these materials, or for any errors or omissions. Last updated: February 2020
Who
should
take this
training
2
Training Modules + Learning
Objectives
3
All areas where HDs are handled and all
reusable equipment and devices must be
deactivated, decontaminated, and cleaned.
4
Additionally, sterile compounding areas and devices must be
subsequently disinfected
Reference 1
Deactivation
5
Treatment of an HD contaminant on surfaces with a chemical,
heat, ultraviolet light, or another agent to transform the HD
into a less hazardous agent.
Reference 1
Decontamination
6
Inactivation, neutralization, or removal of HD contaminants on
surfaces, usually by chemical means.
Reference 1
Cleaning
7
The process of removing soil (e.g., organic and inorganic
material) from objects and surfaces.
Reference 1
Disinfection
8
The process of inhibiting or destroying microorganisms.
Reference 1
Important Information:
Cleaning and Decontamination
9
Reference 2
Wear appropriate PPE for cleaning and
decontaminating work.
10
PPE
Reference 2
Cleaning Materials +
Timing
The deactivating, decontaminating, cleaning, and
disinfecting agents selected must be appropriate for
the type of HD contaminant(s), location, and surface
materials.
12
Reference 1
D
i
s
i
n
f
e
c
t
a
n
t
s
a
n
d
d
e
t
e
r
g
e
n
t
s
s
h
o
u
l
d
b
e
s
e
l
e
c
t
e
d
a
n
d
u
s
e
d
t
o
p
r
e
v
e
n
t
m
i
c
r
o
b
i
a
l
c
o
n
t
a
m
i
n
a
t
i
o
n
13
This Photo
by Unknown Author is licensed under
CC BY-ND
Disinfectants and Detergents
Reference 2
13
The choice of cleaning products
should be related to:
14
Reference 2
Cleaning materials
15
Reference 2
Timing of Cleaning
16
Reference 2
All Surfaces
17
70% IPA may damage the clear plastic surface of some ventilation tools
Reference 2
Validation of
Cleaning Process
2
The objective of validation
is to confirm that
microbiological, chemical,
and other contaminants
are removed or inactivated
during the cleaning
process.
19
Reference 2
Microbiological
Validation
20
M
i
c
r
o
b
i
o
l
o
g
i
c
a
l
v
a
l
i
d
a
t
i
o
n
o
f
t
h
e
c
l
e
a
n
i
n
g
p
r
o
c
e
s
s
u
s
e
s
c
o
n
t
a
c
t
p
l
a
t
e
s
a
n
d
/
o
r
s
w
a
b
s
b
e
f
o
r
e
a
n
d
a
f
t
e
r
t
h
e
c
l
e
a
n
i
n
g
o
p
e
r
a
t
i
o
n
.
Reference 2
Chemical
Validation
Due to the large diversity of
drugs used simultaneously
in the same controlled area,
chemical validation of the
cleaning process is more
complex when handling
cytotoxic drugs.
21
Reference 2
Chemical Validation
Approach
22
Reference 2
References
23
1.
US Pharmacopeia. USP General Chapter <800>
Hazardous Drugs-Handling in Healthcare Settings
[Internet]. 2017
2.
Connor T, McLauchlan R, Vandenbroucke J. ISOPP
Standards of Practice: Safe Handling of Cytotoxics.
J Oncol Pharm Pract. 2007;13(1)
Can choose a background color but it should be light and used only on section headers. Printing will be the deciding factor.
This presentation provides an overview of training on deactivating, decontaminating, cleaning, and disinfecting hazardous drug areas. It covers essential steps, personal protective equipment, materials, timing, and validation criteria. All areas handling hazardous drugs must undergo deactivation, decontamination, cleaning, and disinfection to ensure safety. The training includes information on deactivation, decontamination, and proper handling of hazardous drug contaminants on surfaces.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. Download presentation by click this link. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
E N D
Presentation Transcript
Deactivating, Deactivating, Decontaminating, Cleaning, Decontaminating, Cleaning, and Disinfecting and Disinfecting Overview Training DATE PLACE Disclaimer: This presentation contains information on the general principles for safe handling of hazardous drugs. This presentation cannot account for individual variation among facilities and cannot be considered inclusive of all proper methods of occupational safety. It is the responsibility of the facility management and staff to determine the best course of occupational safety for operations. The American Cancer Society and its partners assume no responsibility for any injury or damage to persons or property arising out of or related to any use of these materials, or for any errors or omissions. Last updated: February 2020
Any staff person responsible for cleaning Hazardous Drug (HD) areas. Who should take this training These staff may include cleaners, technicians, nurses and pharmacists. 2
Training Modules + Learning Objectives Overview of Cleaning Steps Define deactivation, decontamination, cleaning and disinfection. List essential personal protective equipment (PPE). Materials + Timing Determine criteria for materials and products used during cleaning activities. Describe timing of cleaning activities. Describe purpose of cleaning validation. Define microbiological and chemical validation. Validation 3
All areas where HDs are handled and all reusable equipment and devices must be deactivated, decontaminated, and cleaned. Deactivate Decontaminate Clean Disinfect Render compound inert or inactive Remove HD residue Remove organic and inorganic material Destroy microorganisms (peroxide formulations, sodium hypochlorite, (Germicidal detergent) (alcohol, water, peroxide, or sodium hypochlorite ) (EPA-registered disinfectant and/or sterile alcohol) etc.) Additionally, sterile compounding areas and devices must be subsequently disinfected Reference 1 4
Deactivation Treatment of an HD contaminant on surfaces with a chemical, heat, ultraviolet light, or another agent to transform the HD into a less hazardous agent. Renders a compound inert or inactive Residue from deactivation must be removed by decontaminating the surface The ultimate goal should be complete surface decontamination Reference 1 5
Decontamination Inactivation, neutralization, or removal of HD contaminants on surfaces, usually by chemical means. Transfers residue from non disposable surfaces to absorbent materials. Surface compatibility and facility requirements should be considered when selecting products It is imperative to adhere to manufacturer's use instructions Reference 1 6
Cleaning The process of removing soil (e.g., organic and inorganic material) from objects and surfaces. Uses water, detergents, surfactants, solvents, and/or other chemicals Cleaning agents used on compounding equipment should not introduce microbial contamination No cleaning step may be performed when compounding activities are occurring Reference 1 7
Disinfection The process of inhibiting or destroying microorganisms. Before disinfection can be adequately performed, surfaces must be cleaned Disinfection must be done for areas intended to be sterile, including the sterile compounding area Reference 1 8
Important Information: Cleaning and Decontamination Perform cleaning and decontamination work in areas that are sufficiently ventilated. Clean work surfaces with an appropriate deactivation agent. Reference 2 9
PPE An N95 respirator Disposable Gown Goggles Protective Gloves Wear appropriate PPE for cleaning and decontaminating work. Reference 2 10
Cleaning Materials + Timing
The deactivating, decontaminating, cleaning, and disinfecting agents selected must be appropriate for the type of HD contaminant(s), location, and surface materials. The products used must be compatible with the surface material. Consult manufacturer or supplier information for compatibility with cleaning agents used. Reference 1 12
Disinfectants and Detergents Disinfectants and detergents should be selected and used to prevent Disinfectants and detergents should be selected and used to prevent microbial contamination microbial contamination 13 Reference 2 13 This Photo by Unknown Author is licensed under CC BY-ND
The choice of cleaning products should be related to: Time and application Bio-burden Eventual resistance problems Equipment used Reference 2 14
Cleaning materials Generate a low amount of particles Disposable Disposed of along with other cytotoxic waste Reference 2 15
Timing of Cleaning At beginning of each compounding activity session. After liquids are spilled. Reference 2 16
All Surfaces Left on for a time sufficient to exert its antimicrobial effect Cleaned with sterile water for irrigation Disinfected with sterile 70% isopropyl alcohol (IPA) 70% IPA may damage the clear plastic surface of some ventilation tools Reference 2 17
2 Validation of Cleaning Process
The objective of validation is to confirm that microbiological, chemical, and other contaminants are removed or inactivated during the cleaning process. 19 Reference 2
Microbiological Validation Microbiological validation of the Microbiological validation of the cleaning process uses contact plates cleaning process uses contact plates and/or swabs before and after the and/or swabs before and after the cleaning operation. cleaning operation. 20 Reference 2
Due to the large diversity of drugs used simultaneously in the same controlled area, chemical validation of the cleaning process is more complex when handling cytotoxic drugs. Chemical Validation 21 Reference 2
Chemical Validation Approach Wipe Sampling : Investigate the most commonly used cytotoxic drugs. Analytical procedure : Investigation of lipophilic drugs. Cleaning carried out should not degrade the cytotoxic drug into more toxic components. Reference 2 22
23 1. US Pharmacopeia. USP General Chapter <800> Hazardous Drugs-Handling in Healthcare Settings [Internet]. 2017 2. Connor T, McLauchlan R, Vandenbroucke J. ISOPP Standards of Practice: Safe Handling of Cytotoxics. J Oncol Pharm Pract. 2007;13(1) References
