Fat Cow Syndrome in Cattle: Causes, Symptoms, and Treatment
Fat Cow Syndrome
Dr. Vivek Kr. Singh
Assistant Professor
Department of Veterinary Clinical
Complex
UNIT-3
Synonyms
•
FATTY LIVER IN CATTLE
•
FAT-MOBILIZATION SYNDROME
•
HEPATIC LIPIDOSIS
•
PREGNANCY TOXEMIA IN CATTLE
Introduction
•
It is a disease of
high producing
cows
•
Overfed cattle during
dry period
may develop
fatty liver syndrome
just before or after
calving (Transition period)
Etiology
•
Mobilization
of
excessive body fat
to
liver
during periods of
negative energy balance
at
time of parturition or in early lactation of
dairy cows and late pregnancy of beef cows
Pathogenesis
Increase energy demands + Reduced feed intake
Negative Energy Balance
Mobilization of fat from reserve
Fat is transported to liver for gluconeogenesis
Ruminant liver has limited capacity to transport VLDL
Hepatic Lipidosis
Clinical findings
•
Anorexia
•
Depression
•
Weakness
•
Persistent weight loss
•
Recombency
•
Ketosis (Do not respond to glucose treatment)
•
Some animals show nervous signs like star gazing
and tremors of head and neck
•
Coma and death
Necropsy Findings
•
Gross enlargement of liver
•
Liver is pale yellow in color
•
Greasy and friable
•
Histopathology reveals
•
Enlarged hepatocytes with fatty changes
Diagnosis
•
Elevated NEFA
•
Ketone bodies
•
Eleveted LDH
•
Tatal bilirubin
•
AST
•
GGT
•
The liver sample which floats in water and copper
sulphate solution having sp. Gravity ranging
between 1.025 – 1.055 indicates presence of 34%
lipid content in the sample
Treatment
•
Continuous supplementation of
glucose along with
calcium and magnesium
salt to correct negative energy
balance
•
Long acting
protamine zinc insuline @ 200 units
/ cow
every
12 hrly
•
S/c
administration of
choline chloride (25 g in 250 ml
NSS)
•
Niacin@ 6-12g/cow/day
helps in reducing hepatic
lipidosis
•
Antioxidants
•
Anabolic steroids @
300mg/cow
Thank You
Fat Cow Syndrome, also known as Fatty Liver Disease in Cattle, is a condition commonly seen in high-producing cows during the transition period around calving. The disease is characterized by mobilization of excessive body fat to the liver due to negative energy balance, leading to hepatic lipidosis. Clinical signs include anorexia, depression, weakness, and ketosis. Diagnosis involves detecting elevated NEFA and ketone bodies. Treatment includes glucose supplementation, insulin therapy, choline chloride administration, and niacin supplementation to reduce hepatic lipidosis.
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Presentation Transcript
Fat Cow Syndrome UNIT-3 Dr. Vivek Kr. Singh Assistant Professor Department of Veterinary Clinical Complex
Synonyms FATTY LIVER IN CATTLE FAT-MOBILIZATION SYNDROME HEPATIC LIPIDOSIS PREGNANCY TOXEMIA IN CATTLE
Introduction It is a disease of high producing cows Overfed cattle during dry period may develop fatty liver syndrome just before or after calving (Transition period)
Etiology Etiology Mobilization of excessive body fat to liver during periods of negative energy balance at time of parturition or in early lactation of dairy cows and late pregnancy of beef cows
Pathogenesis Increase energy demands + Reduced feed intake Negative Energy Balance Mobilization of fat from reserve Fat is transported to liver for gluconeogenesis Ruminant liver has limited capacity to transport VLDL Hepatic Lipidosis
Clinical findings Anorexia Depression Weakness Persistent weight loss Recombency Ketosis (Do not respond to glucose treatment) Some animals show nervous signs like star gazing and tremors of head and neck Coma and death
Necropsy Findings Gross enlargement of liver Liver is pale yellow in color Greasy and friable Histopathology reveals Enlarged hepatocytes with fatty changes
Diagnosis Elevated NEFA Ketone bodies Eleveted LDH Tatal bilirubin AST GGT The liver sample which floats in water and copper sulphate solution having sp. Gravity ranging between 1.025 1.055 indicates presence of 34% lipid content in the sample
Treatment Continuous supplementation of glucose along with calcium and magnesium salt to correct negative energy balance Long acting protamine zinc insuline @ 200 units/ cow every 12 hrly S/c administration of choline chloride (25 g in 250 ml NSS) Niacin@ 6-12g/cow/day helps in reducing hepatic lipidosis Antioxidants Anabolic steroids @300mg/cow
