Enhancing Translational Research: Bridging the Gap Between Clinical and Basic Scientists
Translational research aims to translate basic scientific discoveries into practical applications for patient care. This involves moving research from the laboratory to clinical settings effectively and safely. Key aspects include designing studies using relevant models, documenting mechanisms of action, overcoming barriers such as funding and interdepartmental collaborations, and maximizing the impact of clinical trials on further research advancement.
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Theme: Translational Research Theme: Translational Research - - Conversation between Clinical Conversation between Clinical and Basic Scientists and Basic Scientists Group 4 ! Image result for mala mahendroo ut southwestern Image result for mala mahendroo ut southwestern Image result for ashley salazar utmb Image result for felipe.vadillo@gmail.com
Question 1: Question 1: What do we mean by translational research? Research to clinic When is basic research ready for translation? Cell culture and lower/higher level animal model testing Effective and safe It would be nice to have established guidelines
Question 2: How to approach design of basic experimental work that is ultimately translatable? What are the necessary factors? Design a study that uses a cell culture or animal mode that is relevant to human biology Treat or not treat with a drug of interest Document mechanism of action Collect data Clinical trials
Question 2: What are the barriers to doing this and how can they be overcome? What are the barriers to doing this and how can they be overcome? Obstacles Animal models How to overcome them Use the right model to ask the right questions NIH does not require a translational section in grants promote this as a standard Funding within Universities for MDs to conduct research advocate for time The barrier between MDs (within departments) and PhDs Virtual groups with incentives, meetings like PREBIC or within your own Universities
Question 3: How do we get the most out of clinical trials, so that the How do we get the most out of clinical trials, so that the results can drive further basic experimentation? results can drive further basic experimentation? Getting lost in translation Basic science and clinical researchers should be involved in the design, follow up, and interpretation of clinical trials Quantity and type of sample collections Guide costs sub-committees Image result for doctors
Provide a platform where people can view potential clinical trials and prepare ancillary studies contributions between universities and between MDs and PhDs Open access to data between networks that is easy to find and understand Image result for doctors
Question 4: How should the current grant review, funding, and regulatory framework for biomedical science be changed to support translational research in preterm birth? It is common to provide sex as a biological factor sections in grants Create a translational relevance section in grants Evaluation of non-responding groups as a separate population
Funding ideas TedTalks or pitches, maybe at SRI, where researchers and clinicians pitch their ideas to entrepreneurs, MDs with large clinical studies, venture capitalists, pharmaceutical companies, etc. Create an angel group for prematurity new funding source Crowdsourcing Advocate for political leverage on funding
