Computerized Provider Order Entry (CPOE) and Its Impact on Patient Safety

This workforce product was funded by a grant awarded by the U.S. Department of Labor's Employment and Training Administration. The product was created by the grantee and does
not necessarily reflect the official position of the U.S. Department of Labor. The Department of Labor makes no guarantees, warranties, or assurances of any kind, express or implied, with
respect to such information, including any information on linked sites and including, but not limited to, accuracy of the information or its completeness, timeliness, usefulness, adequacy,
continued availability, or ownership.
COMPUTERIZED PROVIDER ORDER  
ENTRY
 
(CPOE)
DEFINITION OF
 
CPOE
Computerized 
provider order entry
 
(CPOE)
– Order entry
 
application
Assists practitioners with 
the creation and 
management 
of 
orders
 
for
services 
and
 
medications
HIMSS 
Dictionary of Healthcare Information Technology Terms, Acronyms 
and
 
Organizations
CPOE
Is 
part of an integrated clinical 
information
 
system
•Is 
a 
computer
 application
•Not 
just an 
electronic prescribing
 
system
•Use 
of 
computer assistance 
by a provider to directly enter 
medical
 
orders
from 
a 
computer 
or 
mobile 
device 
for 
further
 
processing
CPOE
Coupled with clinical decision support
 
systems
–Applies 
rules-based
 
logic
–Supplies real-time
 
feedback
–Example
•Alert 
of a drug 
allergy 
with 
a 
suggested alternative
 
medication
PURPOSE OF
 
CPOE
Automate 
the patient ordering 
process 
in order to 
manage 
patient care
more effectively 
and 
efficiently 
and 
as 
a result 
improve 
patient safety
 
and
outcomes
Prevent, reduce, or 
eliminate medical errors 
and 
adverse 
drug
 
events
(ADEs)
•Improve 
patient
 
safety
•Reduce unnecessary variation 
in health
 
care
•Improve 
efficiency 
of health care
 
delivery
PREVENT, 
REDUCE, OR
 
ELIMINATE
 
              
MEDICAL ERRORS AND
 
ADES
               
IOM
 
reports
–98,000 patients die each year in 
U.S. 
hospitals due to medical
 
errors
–Advised rapid adoption of electronic 
medication 
ordering to
 
support
clinical
 
decisions
•CPOE seen 
as a
 
solution
IMPROVE 
PATIENT
 
SAFETY
Leapfrog
 
Group
–Consortium 
of 
major companies 
and other 
large 
private and
 
public
healthcare
 
purchasers
–One 
of 
its 
key patient safety
 
standards
•CPOE seen 
as a 
way 
to “leap”
 
forward
–“leap” is a 
recommended 
hospital quality and 
safety
 
practice
REDUCE 
UNNECESSARY 
VARIATION
 
IN
 
                             
HEALTH
 
CARE
                               
Help the physician 
make optimal 
ordering 
decisions 
and
 
improve
adherence to 
evidence-based
 
practice
•Requires 
configuration of orders and order
 
sets
IMPROVE EFFICIENCY OF 
HEALTH
 
CARE
 
                                 
DELIVERY
                                   
Reduction in order 
verification 
and 
processing
 
times
–Electronic communication 
both
 
directions
•Order 
entered
 
electronically
•Order 
sent 
electronically
•Order 
received
 
electronically
•Status returned
 
electronically
•Requires 
interfaces 
with 
existing 
information
 
systems
ATTRIBUTES 
OF
 
CPOE
Patient
 
ordering
•Patient-centered 
decision
 
support
•Patient safety
 
features
•Optimally 
the 
human computer 
interface is
 
intuitive
Regulatory 
compliance 
and
 
security
•Portability
•Management
ATTRIBUTES 
OF
 
CPOE
Billing
Responsiveness -users are not left
 
hanging
•Response time –prompt response 
to
 
input
•Reliable 
–probability of failure-free
 
operation
FUNCTIONS OF
 
CPOE
Basic: Electronic
 
order
communication
–Accepts/captures 
the
 
provider’s
orders 
for
 
services
–Transmits 
the order to
 
the
appropriate
 
location
–Returns 
status 
of
 
order
–Returns 
results 
of
 
order
execution
Advanced: includes
 
clinical
decision
 
support
–Simple: 
drug-drug
 
interaction
checks, 
medication 
dose
calculators
–Complex: 
Alert of a drug
 
allergy
along 
with 
an 
alternative
medication
CPOE AND 
CLINICAL 
DECISION
 
SUPPORT
 
                             
SYSTEM(CDSS)
                              
Clinical 
Decision 
Support 
System
 
(CDSS)
–Uses pre-established 
rules and
 
guidelines
–Integrates 
clinical data form several
 
sources
–Generates alerts 
and 
treatment
 
suggestions
HIMSS 
Dictionary of 
Healthcare Information 
Technology
 
Terms,
Acronyms 
and 
Organizations,
 
2010
•CPOE 
needs clinical 
decision support 
to 
reach 
its 
full
 
value
CPOE AND 
CLINICAL 
DECISION
 
SUPPORT
 
                             
SYSTEM(CDSS)
                              
Three 
parts 
to
 
CDSS
–Knowledge 
base, aka the
 
“rules-engine”
–Inference
 
engine
–Mechanism to
 
communicate
CPOE AND 
CLINICAL 
DECISION
 
SUPPORT
 
                             
SYSTEM(CDSS)
                              
No 
single approach to
 
integration
•Questions 
to
 
ask
–“What 
kind and how 
much 
clinical
 
support?”
–“What 
about 
medication alerts, allergies, routine 
preventive
 
diagnostics?”
–“How 
many alerts will 
users tolerate before ignoring
 
them?”
–“How 
difficult 
should 
it be 
for 
the 
practitioners 
to 
override 
the
 
alerts?”
CPOE
 
USERS
Physicians
•Nurses
•Physician
 
assistants
•Nurse
 practitioners
•Therapists
•Pharmacists
•Others
CPOE
 
USES
Applies 
to both the inpatient and 
ambulatory
 
setting
•Order
 
types
–Medications
–Tests, 
e.g.,
 
laboratory
–Procedures
–Other clinical 
processes 
such 
as admissions,
 
referrals
ADVANTAGES 
OF CPOE OVER
 
PAPER-
 
                           
BASED
 
SYSTEMS
                            
Free of handwriting 
identification
 
problems
•Faster 
to reach
 
pharmacy
•Less 
subject to error associated 
with similar 
drug
 
names
•More 
easily integrated into 
medical records 
and decision-support
 
systems
Koppel, R., 
et al 
Role of Computerized Physician Order 
Entry 
Systems in Facilitating Medication Errors 
, 
http://jama.ama- 
assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a
ADVANTAGES 
OF CPOE OVER
 
PAPER-
 
                           
BASED
 
SYSTEMS
                            
Less subject 
to 
errors 
caused by 
use 
of apothecary
 
measures
•Easily 
linked to 
drug-drug interaction
 
warnings
•More 
likely to 
identify 
the prescribing
 
physician
•Able 
to link to 
ADE reporting
 
systems
Koppel, R., 
et al 
Role of Computerized Physician Order 
Entry 
Systems in Facilitating Medication Errors 
, 
http://jama.ama- 
assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a
ADVANTAGES 
OF CPOE OVER
 
PAPER-
 
                           
BASED
 
SYSTEMS
                            
Able to avoid 
specification
 
errors
•Available 
and appropriate 
for 
training and
 
education
•Available 
for immediate 
data
 
analysis
•Claimed 
to generate 
significant economic
 
savings
Koppel, R., 
et al 
Role of Computerized Physician Order 
Entry 
Systems in Facilitating Medication Errors 
, 
http://jama.ama- 
assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a
ADVANTAGES 
OF CPOE OVER
 
PAPER-
 
                           
BASED
 
SYSTEMS
                            
With 
online 
prompts, CPOE systems
 
can
–Link to 
algorithms 
to 
emphasize cost-effective
 
medications
–Reduce 
underprescribing 
and
 
overprescribing
–Reduce incorrect drug
 
choices
Koppel, R., 
et al 
Role of Computerized Physician Order 
Entry 
Systems in Facilitating Medication Errors 
, 
http://jama.ama- 
assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a
MAJOR 
VALUE 
OF
 
CPOE
Enhanced patient
 
safety
•Reduced 
costs
•Reduced variations 
in care by encouraging best
 
practices
MAJOR
 
BARRIERS
Belief that 
physicians will 
not 
use computerized
 
ordering
•Not 
a 
small 
or easy 
task
•Impact 
on
 
workflow
•Risk
•Cost
E-IATROGENESIS
•“Patient 
harm caused at 
least 
in part by the 
application 
of
 
health
information
 
technology”
•Probability 
of 
medication 
errors
 
increases
Weiner, J. et al. “e-Iatrogenesis”: The Most 
Critical 
Unintended Consequence of 
CPOE and 
other 
HIT
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244888
MEDICATION 
ERROR
 
RISKS
Information
 
errors
–Medication 
discontinuation
 
failures
–Procedure-linked medication discontinuation
 
faults
–Immediate 
order and give-as-needed 
medication discontinuation
 
faults
–Antibiotic 
renewal
 
failure
–Diluent 
options 
and
 
errors
–Allergy information
 
delay
Koppel, R., 
et al 
Role of Computerized Physician Order 
Entry 
Systems in Facilitating Medication
 
Errors 
, 
http://jama.ama-
assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a
MEDICATION 
ERROR
 
RISKS
 
     
HUMAN-MACHINE 
INTERFACE
 
FLAWS
      
Patient selection
Wrong 
medication selection
Unclear logon/log
 
off
Role 
of charting 
difficulties in inaccurate 
and
delayed 
medication
 
administration
Post-surgery“suspended”
 
medications
Loss
 
of
 
data,
 
time,
 
and
 
focus
 
when 
CPOE
 
is
nonfunctional
Late-in-day orders 
lost for 
24
 
hours
Failure 
to 
provide 
medications after
 
surgery
Sending medications to 
wrong rooms 
when the
computer system has shut
 
down
Inflexible 
ordering screens, incorrect
 
medications
MAJOR 
SUPPORT 
FOR CPOE
 
ADOPTION
HITECH
 
Act
–Use 
of health 
information 
technology
 
in
•Improving 
the quality of health
 
care
•Reducing medical
 
errors
•Reducing 
health
 
disparities
•Increasing
 
prevention
•Improving 
the continuity of care 
among 
health care
 
settings
ELECTRONIC 
HEALTH 
RECORD
 
INCENTIVE
 
                    
PROGRAM FINAL
 
RULE
                      
Stage
 
1
–CPOE 
included in the core set of
 
measures
–Only 
medication
 
orders
•30% threshold (60% for Stage
 
2)
–Transmission 
of the order is not included in the objective or
 
the
associated
 
measure
•Any 
licensed healthcare professional can enter 
orders 
into the
 
medical
record per state, local and professional
 
guidelines
CPOE’S
 
IMPACT
CPOE 
can 
with 
Clinical Decision 
Support
 
(CDS)
–Improve 
medication safety 
and 
quality 
of
 
care
–Reduce costs of
 
care
–Improve compliance with provider
 
guidelines
–Improve the 
efficiency 
of hospital
 
workflow
Inpatient Computerized Provider Order 
Entry 
(CPOE): Findings from 
the 
AHRQ Health 
IT 
Portfolio.
http://healthit.ahrq.gov/portal/server.pt/gateway/PTARGS_0_1248_846328_0_0_18/09-0031- 
 EF_cpoe.pdf
CPOE’S
 
IMPACT
Improve 
the 
efficiency
•Improve compliance with 
evidence-base
 
practices
Inpatient Computerized Provider Order 
Entry 
(CPOE): Findings from 
the 
AHRQ Health 
IT 
Portfolio. 
http://healthit.ahrq.gov/portal/server.pt/gateway/PTARGS_0_1248_846328_0_0_18/09-0031- 
EF_cpoe.pdf
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Computerized Provider Order Entry (CPOE) is a critical component of healthcare technology that automates the patient ordering process to enhance efficiency, reduce medical errors, and improve patient safety outcomes. Integrated with clinical decision support systems, CPOE applies rules-based logic to offer real-time feedback, such as alerting healthcare providers of potential drug interactions. Rapid adoption of electronic medication ordering, supported by CPOE, is seen as a solution to prevent, reduce, or eliminate medical errors leading to adverse drug events. The ultimate goal is to manage patient care effectively while enhancing healthcare delivery efficiency.

  • CPOE
  • Healthcare Technology
  • Patient Safety
  • Medical Errors
  • Clinical Decision Support

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  1. COMPUTERIZED PROVIDER ORDER ENTRY (CPOE) This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at https://www.healthit.gov/. This workforce product was funded by a grant awarded by the U.S. Department of Labor's Employment and Training Administration. The product was created by the grantee and does not necessarily reflect the official position of the U.S. Department of Labor. The Department of Labor makes no guarantees, warranties, or assurances of any kind, express or implied, with respect to such information, including any information on linked sites and including, but not limited to, accuracy of the information or its completeness, timeliness, usefulness, adequacy, continued availability, or ownership.

  2. DEFINITION OF CPOE Computerized provider order entry (CPOE) Order entry application Assists practitioners with the creation and management of ordersfor services and medications HIMSS Dictionary of Healthcare Information Technology Terms, Acronyms and Organizations

  3. CPOE Is part of an integrated clinical informationsystem Is a computer application Not just an electronic prescribing system Use of computer assistance by a provider to directly enter medicalorders from a computer or mobile device for further processing

  4. CPOE Coupled with clinical decision support systems Applies rules-based logic Supplies real-time feedback Example Alert of a drug allergy with a suggested alternative medication

  5. PURPOSE OF CPOE Automate the patient ordering process in order to manage patient care more effectively and efficiently and as a result improve patient safetyand outcomes Prevent, reduce, or eliminate medical errors and adverse drug events (ADEs) Improve patient safety Reduce unnecessary variation in health care Improve efficiency of health care delivery

  6. PREVENT, REDUCE, OR ELIMINATE MEDICAL ERRORS ANDADES IOM reports 98,000 patients die each year in U.S. hospitals due to medical errors Advised rapid adoption of electronic medication ordering tosupport clinical decisions CPOE seen as a solution

  7. IMPROVE PATIENTSAFETY Leapfrog Group Consortium of major companies and other large private and public healthcare purchasers One of its key patient safety standards CPOE seen as a way to leap forward leap is a recommended hospital quality and safetypractice

  8. REDUCE UNNECESSARY VARIATIONIN HEALTH CARE Help the physician make optimal ordering decisions and improve adherence to evidence-based practice Requires configuration of orders and order sets

  9. IMPROVE EFFICIENCY OF HEALTHCARE DELIVERY Reduction in order verification and processingtimes Electronic communication both directions Order entered electronically Order sent electronically Order received electronically Status returned electronically Requires interfaces with existing informationsystems

  10. ATTRIBUTES OF CPOE Patient ordering Patient-centered decision support Patient safety features Optimally the human computer interface is intuitive Regulatory compliance and security Portability Management

  11. ATTRIBUTES OF CPOE Billing Responsiveness -users are not left hanging Response time prompt response to input Reliable probability of failure-freeoperation

  12. FUNCTIONS OF CPOE Basic: Electronicorder communication Advanced: includesclinical decision support Accepts/captures the provider s orders for services Simple: drug-drug interaction checks, medication dose calculators Transmits the order to the appropriate location Complex: Alert of a drugallergy along with an alternative medication Returns status of order Returns results of order execution

  13. CPOE AND CLINICAL DECISIONSUPPORT SYSTEM(CDSS) Clinical Decision Support System (CDSS) Uses pre-established rules and guidelines Integrates clinical data form severalsources Generates alerts and treatment suggestions HIMSS Dictionary of Healthcare Information TechnologyTerms, Acronyms and Organizations, 2010 CPOE needs clinical decision support to reach its fullvalue

  14. CPOE AND CLINICAL DECISIONSUPPORT SYSTEM(CDSS) Three parts to CDSS Knowledge base, aka the rules-engine Inference engine Mechanism to communicate

  15. CPOE AND CLINICAL DECISIONSUPPORT SYSTEM(CDSS) No single approach to integration Questions to ask What kind and how much clinical support? What about medication alerts, allergies, routine preventivediagnostics? How many alerts will users tolerate before ignoring them? How difficult should it be for the practitioners to override the alerts?

  16. CPOE USERS Physicians Nurses Physician assistants Nurse practitioners Therapists Pharmacists Others

  17. CPOE USES Applies to both the inpatient and ambulatory setting Order types Medications Tests, e.g., laboratory Procedures Other clinical processes such as admissions, referrals

  18. ADVANTAGES OF CPOE OVER PAPER- BASED SYSTEMS Free of handwriting identification problems Faster to reach pharmacy Less subject to error associated with similar drug names More easily integrated into medical records and decision-supportsystems Koppel, R., et al Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors , http://jama.ama- assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a

  19. ADVANTAGES OF CPOE OVER PAPER- BASED SYSTEMS Less subject to errors caused by use of apothecary measures Easily linked to drug-drug interaction warnings More likely to identify the prescribingphysician Able to link to ADE reportingsystems Koppel, R., et al Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors , http://jama.ama- assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a

  20. ADVANTAGES OF CPOE OVER PAPER- BASED SYSTEMS Able to avoid specification errors Available and appropriate for training and education Available for immediate data analysis Claimed to generate significant economicsavings Koppel, R., et al Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors , http://jama.ama- assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a

  21. ADVANTAGES OF CPOE OVER PAPER- BASED SYSTEMS With online prompts, CPOE systems can Link to algorithms to emphasize cost-effective medications Reduce underprescribing and overprescribing Reduce incorrect drug choices Koppel, R., et al Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors , http://jama.ama- assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a

  22. MAJOR VALUE OF CPOE Enhanced patient safety Reduced costs Reduced variations in care by encouraging best practices

  23. MAJOR BARRIERS Belief that physicians will not use computerized ordering Not a small or easy task Impact on workflow Risk Cost

  24. E-IATROGENESIS Patient harm caused at least in part by the application ofhealth information technology Probability of medication errors increases Weiner, J. et al. e-Iatrogenesis : The Most Critical Unintended Consequence of CPOE and other HIT http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244888

  25. MEDICATION ERROR RISKS Information errors Medication discontinuation failures Procedure-linked medication discontinuation faults Immediate order and give-as-needed medication discontinuation faults Antibiotic renewal failure Diluent options and errors Allergy information delay Koppel, R., et al Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors , http://jama.ama- assn.org/cgi/content/full/293/10/1197?ijkey=83e2c4349737ab8b717ca9f12ccdca4a1de9f26a

  26. MEDICATION ERROR RISKS HUMAN-MACHINE INTERFACE FLAWS Patient selection Loss of data,time,and focus when CPOE is nonfunctional Wrong medication selection Late-in-day orders lost for 24 hours Unclear logon/log off Failure to provide medications after surgery Role of charting difficulties in inaccurate and delayed medication administration Sending medications to wrong rooms when the computer system has shut down Post-surgery suspended medications Inflexible ordering screens, incorrect medications

  27. MAJOR SUPPORT FOR CPOEADOPTION HITECHAct Use of health information technology in Improving the quality of health care Reducing medical errors Reducing health disparities Increasing prevention Improving the continuity of care among health care settings

  28. ELECTRONIC HEALTH RECORD INCENTIVE PROGRAM FINALRULE Stage 1 CPOE included in the core set of measures Only medication orders 30% threshold (60% for Stage 2) Transmission of the order is not included in the objective orthe associated measure Any licensed healthcare professional can enter orders into themedical record per state, local and professional guidelines

  29. CPOES IMPACT CPOE can with Clinical Decision Support (CDS) Improve medication safety and quality of care Reduce costs of care Improve compliance with providerguidelines Improve the efficiency of hospital workflow Inpatient Computerized Provider Order Entry (CPOE): Findings from the AHRQ Health IT Portfolio. http://healthit.ahrq.gov/portal/server.pt/gateway/PTARGS_0_1248_846328_0_0_18/09-0031- EF_cpoe.pdf

  30. CPOES IMPACT Improve the efficiency Improve compliance with evidence-base practices Inpatient Computerized Provider Order Entry (CPOE): Findings from the AHRQ Health IT Portfolio. http://healthit.ahrq.gov/portal/server.pt/gateway/PTARGS_0_1248_846328_0_0_18/09-0031- EF_cpoe.pdf

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