This study presents findings from the PROSPECTOR clinical trial on the prevalence of the KIT D816V mutation in the peripheral blood of patients with systemic mast cell activation. The study involves multiple centers globally and sheds light on the significance of this mutation in systemic mastocytos

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The presentation slides discuss various dermatologic manifestations of diabetes mellitus, including acanthosis nigricans, diabetic dermopathy, acrochordons (skin tags), and necrobiosis lipoidica diabeticorum (NLD). Each feature description, location, mechanism, and treatment options are detailed alo

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Systemic mycoses are fungal infections caused by dimorphic fungi such as Histoplasma capsulatum, Blastomyces dermatitidis, and Cryptococcus neoformans. Histoplasmosis is transmitted through inhalation of spores from soil or bat-infested caves, presenting with tuberculate macroconidia and microconidi

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Explore the cutaneous manifestations of systemic diseases, particularly focusing on endocrine disorders like diabetes mellitus. Learn about the dermatologic signs associated with conditions such as hypothyroidism, hyperthyroidism, Addison's disease, and Cushing syndrome. Discover specific manifestat

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Explore the role of language in everyday life, the principles of Systemic Functional Linguistics, and the application of discourse analysis in translation. Delve into the Hallidayan model of language and discourse, examining genre, register, sociocultural environment, and more.

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Cholestasis is characterized by reduced bile flow and elevated direct bilirubin. It is critical to differentiate it from neonatal jaundice. In conditions like biliary atresia and 1-antitrypsin deficiency, early diagnosis and intervention are crucial to prevent liver failure. Clinical manifestations

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Explore the complexities of racism, systemic issues, and white fragility in community engagement and research collaborations. Delve into the importance of acknowledging white privilege and understanding systemic racism, focusing on the need for white individuals to actively participate in conversati

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Explore diverse perspectives on racism and racial disparities through personal narratives and societal observations. Engage in conversations about identity, cultural heritage, and confronting biases. Witness the impact of historical patterns and systemic injustices on individuals and communities, wi

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Local anesthetics are crucial in anesthesia for their ability to prevent nerve depolarization, but systemic toxicity can lead to serious complications. Last Causes, signs, and max dosage discussion along with the importance of recognizing early signs like lightheadedness, tinnitus, and late symptoms

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Explore the world of fungi and fungal infections in this foundation block of microbiology. Learn about medically important yeasts, mold fungi, major fungal diseases, antifungal agents, and infection acquisition methods. Dive into hypersensitivity reactions, mycotoxicoses, and various types of fungal

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Serials in library cataloging are modeled as complex constructs in IFLA LRM with considerations for whole/part and aggregation relationships. This module explores the intricacies of serial manifestations, issue manifestations, and the concept of WEM lock, providing insights into collocating closely-

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The 2020 Disparity Study, presented by Mr. Kevin Williams and Ms. Betsy Sava from BBC, delves into the investigation of systemic discrimination in business practices. The study combines statistical evidence with anecdotal research to highlight disparities and barriers faced by minority-owned busines

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Systemic sclerosis (SScl) is an autoimmune disorder affecting connective tissue, leading to fibrosis in the skin, internal organs, and vasculature. It is characterized by Raynaud's phenomenon, digital ischemia, sclerodactyly, and cardiac, lung, gut, and renal involvement. Peak onset is in the fourth

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Rickettsia, a genus of Gram-negative bacteria transmitted by arthropods, is responsible for diseases like Rocky Mountain spotted fever. It causes symptoms such as high fever, rash, and severe headache. Laboratory diagnosis involves serology and isolation from experimental animals. Learn more about R

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Human Immunodeficiency Virus (HIV) is a retrovirus causing Acquired Immunodeficiency Syndrome (AIDS). HIV leads to immune system destruction, making individuals vulnerable to opportunistic infections and tumors. Common sexually transmitted diseases like syphilis, chlamydia, and gonorrhea are discuss

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Congestive heart failure (CHF) is a condition characterized by systemic and pulmonary congestion due to the heart's inability to pump sufficient blood for the body's metabolism. It is closely linked to age and involves pathophysiology related to preload, afterload, contractility, and heart rate. Man

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Chemical mediators of inflammation play a pivotal role in inducing specific events during acute inflammation. These mediators are produced in response to various triggers, including microbial products and host proteins, leading to a cascade of inflammatory responses. Understanding the sources and ef

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This content delves into the crucial role of litigation in combatting systemic discrimination, particularly in the context of under-representation of women in male-dominated work environments. It emphasizes the need for multiple strategies, including legal action, to address discriminatory barriers

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This content explores various systemic diseases and their oral manifestations relevant to dentistry. It covers associations between heart disease and periodontal disease, effects of chronic corticosteroid use on the pulmonary system, endocrine disorders like diabetes and thyroid issues, autoimmune d

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Portal vein imaging is crucial for evaluating conditions affecting the abdominal part of the gastrointestinal tract. Techniques such as spleno-portography and CT triphasic contrast imaging are used to visualize the portal vein and diagnose anomalies like portal-systemic collaterals and porto-systemi

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The relationship between oral health and systemic diseases is significant, with manifestations within the oral cavity providing clues to underlying systemic issues. Disease processes involve aspects like etiology, pathogenesis, morphologic changes, and clinical significance. Organisms and toxins spr

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End-of-life care focuses on addressing the physical and psychosocial needs of individuals and their families during the dying process. It aims to provide comfort, supportive care, and improve the quality of life in the remaining days. Death occurs when vital organs cease to function, and specific ph

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This study discusses systemic climate risk in the financial sector by examining the effects of climate risks on financial institutions. It aims to design a market-based framework to assess the vulnerability of financial institutions to climate risks and analyze potential contagion effects. The frame

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Cellular injury can occur due to various factors like physical trauma, chemicals, radiation, and biologic agents. This process can lead to reversible or irreversible damage in cells, affecting their normal functions and possibly leading to cell death. Manifestations of cellular injury include cellul

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Human Immunodeficiency Virus (HIV) is a lentivirus that infects CD4 T lymphocytes, leading to Acquired Immunodeficiency Syndrome (AIDS). Cutaneous manifestations of HIV/AIDS vary depending on the stage of infection and CD4 T cell counts. Early signs include exanthem, oral hairy leukoplakia, candidia

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Edema, an excessive accumulation of fluid in tissue spaces, is caused by disruptions in fluid exchange mechanisms. It can result from various factors such as increased hydrostatic pressure, decreased plasma oncotic pressure, increased capillary permeability, and obstruction to lymphatic flow. Differ

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This lecture series discusses the various skin manifestations of connective tissue diseases, focusing on Lupus Erythematosus and other related conditions. It covers different types of Lupus, its effects on the body systems, treatment options, and psychosocial impacts. Additionally, the presentation

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This content delves into the intricacies of upper and lower motor neuron lesions, detailing their effects and manifestations in the human body. It explores the causes, types of paralysis, reflexes, muscle tone changes, and the impact of lesions at various levels of the motor system. The insights pro

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Brucellosis, also known as Malta fever or Mediterranean fever, is a systemic bacterial infection caused by Brucella species. This overview covers the identification of the disease, its transmission methods, clinical presentation, complications, diagnostic investigations, treatment options, and preve

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Neisseria gonorrhoeae, also known as gonococcus, is a bacterial pathogen responsible for gonorrhea. The virulence factors of N. gonorrhoeae include pili/fimbriae for adhesion, outer membrane proteins like Porin for protection, opacity-associated protein for adhesion to neutrophils, and more. Clinica

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Dermatitis is a common skin disorder characterized by inflammation, itching, redness, and skin lesions. This article explores the etiology, types (such as contact dermatitis and atopic dermatitis), and clinical manifestations of dermatitis, including acute and chronic phases. Learn about the risk fa

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Hypothyroidism is characterized by an underactive thyroid gland, leading to a variety of symptoms. This detailed presentation covers the causes, manifestations, and treatments of hypothyroidism, with a focus on the drugs used for treatment. Learn about different classes of medications, their mechani

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Explore the systemic change approach to combating unjust structures that oppress individuals living in poverty. Delve into understanding systems as interconnected wholes and the significance of systemic thinking in driving transformation. Uncover the complexities of social systems and the need to ac

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Juvenile Idiopathic Arthritis (JIA) is arthritis of unknown origin that starts before the 16th birthday and lasts at least 6 weeks. It was previously known as juvenile rheumatoid arthritis (JRA). The diagnosis of JIA requires meeting specific criteria, and it can be classified into various subtypes

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Delve into the intricate details of creation and manifestations according to ancient texts, understanding the diverse inhabitants and landscapes across the universe. Learn about the purposeful organization of different beings in various environments, guided by the profound laws of nature and the int

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Necrotizing Enterocolitis (NEC) is a serious condition affecting mainly premature infants, with unknown exact causes but potential risk factors like impaired mucosal barrier and feeding issues. Clinical manifestations include feeding intolerance, abdominal distention, and blood in stools. Diagnosis

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Early life intervention has been shown to reduce the clinical manifestations of Sjögren's syndrome in NOD.H-2h4 mice, which mimic key features of the human autoimmune disease. The syndrome is characterized by salivary gland autoantibodies, ectopic lymphoid follicles, reduced salivary and tear flow,

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Pruritus, commonly known as itching, is a prevalent dermatological concern that can occur due to various factors, including underlying skin conditions, systemic diseases, medications, and neurological disorders. Primary and secondary pruritus are distinguished based on their origin. The sensation ar

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Rickettsiae are pleomorphic intracellular coccobacilli with unique parasitic behavior, leading to vascular lesions and systemic manifestations in humans. The infections are spread by insect vectors and are characterized by fever, headache, malaise, skin rash, and organ enlargement. Different types o

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The Accelerating Systemic Change Network (ASCN) held its inaugural workshop in July 2016 at the Howard Hughes Medical Institute. The event focused on introducing ASCN, its goals, and working group topics to facilitate collaboration among change researchers in higher education. ASCN aims to be a prof

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