This lecture on general chemotherapy outlines the properties of ideal antimicrobial agents, emphasizing selective and effective activity, bactericidal action, non-toxicity, and more. It also covers the classification of antimicrobials based on chemical structure, including sulfonamides, diaminopyrim

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Folate-derived cofactors are crucial for cell growth, with bacteria relying on de novo synthesis while humans need preformed folate. Antifolates like sulfonamides and trimethoprim disrupt folate synthesis in bacteria, inhibiting DNA synthesis. This article explores how these drugs target bacterial e

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Antibacterial sulfonamides were the first effective chemotherapeutic agents used systemically to cure bacterial infections in humans, leading to a decline in infectious disease morbidity. Despite rapid resistance development, they still find use in opportunistic infections, with limited applications

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