Polymorphism and Variant Analysis Lab Exercise Overview
This document outlines a lab exercise on polymorphism and variant analysis, covering tasks such as running Quality Control analysis, Genome Wide Association Test (GWAS), and variant calling. Participants will gain familiarity with PLINK toolkit and explore genotype data of two ethnic groups. Instruc
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Advancements in Statistical Genomics: FarmCPU and Method Development
Exploring the evolution of statistical genomics techniques, this lecture delves into the history of FarmCPU and BLINK, addressing challenges in GWAS and the development of models like PC+SNP+e and PC+Kinship+e. It also covers popular software packages in the field and the importance of moving beyond
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Understanding eQTL Analysis in Gene Expression Profiling
This module delves into Expression QTL (eQTL) analysis, which links genotype to phenotype through transcript abundance modulation. The complexity of eQTLs, including cis vs. trans regulation, clustering, and the genetic component of transcription, is explored. Meta-analyses and tools like GTEx provi
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