Explore the diagnostic considerations for multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and related conditions, including indications for serum protein electrophoresis (SPEP) and free light chain (FLC) testing. Learn when not to order SPEP and FLC, and consider various

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Multiple myeloma is a significant hematologic malignancy with varying stages of progression. From the asymptomatic MGUS to the more advanced SMM, early diagnosis and risk stratification are crucial. The presence of myeloma defining events, specific biomarkers, and established criteria guide the diag

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