Understand the metabolism of calcium and phosphorus, common disturbances, and nutrient requirements in preterm infants. Learn why metabolic bone disease is important and its long-term effects on bone health.

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Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a

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Dr. Srilekha Ammapalli discusses the cations (sodium, potassium, calcium, magnesium) and anions (chloride, bicarbonate, phosphate, lactate) involved in electrolyte and metabolic disturbances in critically ill patients. The physiology, causes of abnormalities, diagnosis, evaluation, and management of

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Explore a case study on diabetic ketoacidosis to understand the basis of metabolic acidosis in type 1 diabetes mellitus, differentiate between type 1 and type 2 diabetes, predict blood buffer equilibrium changes, apply Winter's formula, correlate clinical data with biochemical tests, explain insulin

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The natural history of disease development outlines the progression of a disease in an individual without intervention, from exposure to outcome. Learning objectives include defining prevention terms, understanding disease severity, prevention levels, and intervention measures. Studying disease prog

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Phosphatase enzymes play a crucial role in various metabolic processes by releasing phosphate groups, increasing their availability for energy synthesis and cell structure formation. Acid phosphatases, with an optimum pH below 7.0, can be extracted from plant tissues like germinating mung beans. A p

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Explore the major metabolic pathways of glucose, including glycogenolysis, gluconeogenesis, glycolysis, and more. Understand the production, utilization, catabolic, and anabolic cycles of glucose in cellular metabolism. Learn about key concepts such as hexose interconversion, HMP/PPP, Krebs cycle, a

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The AMPK system plays a crucial role in regulating energy homeostasis by sensing the cellular AMP:ATP ratio and responding to metabolic stresses that affect ATP production or consumption. AMPK is activated by factors such as hypoxia, glucose deprivation, and metabolic inhibitors, as well as by compo

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Epidemiology is the study of disease patterns, factors influencing disease occurrence, and the core functions of surveillance, field investigation, and analytic studies. It involves understanding disease characteristics, natural history, and evaluating the effectiveness of activities to mitigate dis

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This content explores various techniques used in pharmacognosy and phytochemistry to investigate the metabolic pathways in plants and study the formation of primary and secondary metabolites. Methods such as utilizing radioactive isotopes, tracer techniques, isolated organs/tissues, grafting, and mu

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Many critical illnesses can disrupt acid-base balance, indicating underlying diseases or organ damage. Interpretation of disturbances requires analyzing arterial blood gases, plasma electrolytes, and compensatory mechanisms. Acid-base disorders are classified into respiratory acidosis, respiratory a

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The prevention, control, and treatment of nutritional and metabolic diseases in zoo and wild animals are essential for maintaining their health. These diseases, such as rickets, osteoporosis, osteomalacia, and fibrous osteodystrophy, can result from imbalances in dietary nutrients and metabolic dera

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Tyzzer's disease is an acute bacterial infection affecting rodents and rabbits, caused by Clostridium piliforme. Discovered in 1917 by Ernest Tyzzer, the disease is characterized by necrotic lesions in the caecal mucosa, liver, and heart. Initially known as Bacillus piliformis, it was later renamed

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Abomasal displacement refers to the movement of the abomasum, a wandering organ in cattle due to loose attachments. This condition can lead to left or right displacement, as well as torsion or volvulus. Various factors such as feeding high concentrate rations, metabolic alkalosis, and other metaboli

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Metabolic control mechanisms play a crucial role in maintaining homeostasis within cells by regulating metabolic pathways. This involves finely adjusting the output of pathways in response to external signals, ensuring the proper flux of metabolites to meet cellular needs. Pacemaker enzymes, such as

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This educational material delves into the types and biosynthesis of thyroid hormones, the physiological actions of thyroid hormones, regulation levels, thyroid function tests, goiter, and the distinction between hypo- and hyperthyroidism. It covers the role of thyroid hormones in thermogenesis, meta

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This article discusses disease control processes in epidemiology, including reducing disease incidence, duration, and transmission. It covers public policy interventions, elimination, eradication, and extinction of infectious agents. It also highlights preventable causes of disease and different lev

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Cutaneous circulation plays a vital role in supplying blood to the skin, with variations in apical and non-apical regions of the body. The blood flow is regulated by neural, thermal, and metabolic factors, and controlled by sympathetic fibers. Sympathetic vasoconstriction and vasodilation affect the

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Gain insight into the critical role of nutrition in aiding patients in their recovery from injuries and enhancing their physical well-being post-injury. Explore the phases of injury, the physiological and metabolic impacts of each phase, and the corresponding nutritional support strategies. Delve in

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Perinatal asphyxia refers to the interruption of oxygen supply to the fetus or newborn, leading to metabolic consequences and potential multiorgan dysfunction and long-term neurological issues. The American Academy of Pediatrics (AAP) and the American College of Obstetrics and Gynecology (ACOG) have

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Glycine, the simplest amino acid, plays a crucial role in various metabolic pathways in the body. It can be converted to important compounds like pyruvic acid, lactic acid, and creates the one-carbon pool. Glycine is essential for heme synthesis, glutathione formation, purine synthesis, and more. In

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Inborn Errors of Metabolism (IEM) are genetic disorders that disrupt metabolic pathways, leading to substrate accumulation or product deficiency. These disorders can be classified based on toxic accumulation, protein metabolism, carbohydrate intolerance, lysosomal storage issues, energy production d

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Energy is essential for various bodily functions, with Basal Metabolic Rate (BMR) representing the energy needed to sustain internal organ activity and body temperature. Kilocalories from food play a crucial role, and maintaining an energy balance is key for overall health. Factors like exercise, ho

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Patients with coronary artery disease should be screened for peripheral vascular disease as it is a frequent integrator of global cardiovascular risk. The association of atherosclerosis in various arterial diseases highlights the importance of identifying multisite artery disease. The prevalence and

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The Human Disease Symptom Network (HSDN) is constructed using a large-scale medical bibliographic records database to form a network of human diseases based on symptom similarities. By integrating disease-gene associations and protein-protein interaction data, correlations between symptom similarity

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Metabolic rate, the energy consumed by an organism in a specific time period, can be measured through heat energy, oxygen consumption, and carbon dioxide release. Various tools like calorimeters and respirometers are used for this purpose. The delivery of oxygen through efficient transport systems i

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A study by Stefano Lazzer, Grace O. Malley, and Michel Vermorel explores the metabolic and mechanical costs of sedentary and physical activities in obese children and adolescents. The research delves into the main components of daily energy expenditure, the contribution of organs and tissues to body

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Columnaris disease, also known as Saddleback disease, is a common bacterial infection in fish that is often brought about by poor handling and high stress levels. This disease manifests as tail and fin rot, leading to rapid fish mortality. The causative organism, Cytophaga (formerly Flexibacter), is

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Dr. Zoidis Evangelos is a distinguished professional in the field of endocrinology and metabolic syndrome, currently serving as a Lecturer at the Agricultural University of Athens. With a background in biochemistry and extensive research experience, his work focuses on nutritional physiology, molecu

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Explore the case of a 48-year-old RN facing various health challenges like depression, anxiety, obesity, diabetes, and more. Learn about core metabolic imbalances impacting brain health, personalized lifestyle medicine strategies, and the importance of addressing root causes for a balanced metabolic

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Trillions of bacteria in our gut play a crucial role in obesity and metabolic diseases. By analyzing studies on antibiotic effects, bacterial composition, and diet impact, we learn how gut bacteria influence weight gain, energy use, and overall health. Research shows diverse bacterial types affect w

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Metabolic rate, the amount of energy used by the body over time, can be measured in different ways using respirometers and calorimeters. Respirometers measure oxygen uptake, while calorimeters calculate metabolic rate based on heat generated by the organism. Understanding these techniques is essenti

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Malignant Hyperthermia (MH) is a genetic disorder of skeletal muscle triggered by certain anesthetics, leading to a hyper-metabolic state. The uncontrolled release of calcium results in muscle rigidity, metabolic acidosis, hyperthermia, and other serious complications. MH was first described in the

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Explore the latest findings from the Alzheimer's Disease Genetics Symposium 2019 on disease mechanisms, drug targets, and genetic pathways. Dive into the progress made by the Alzheimer's Disease Genetics Consortium over the past decade. Transition to a Genome-Wide Association Study uncovering suscep

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Maple Syrup Urine Disease (MSUD) is a metabolic disorder affecting the breakdown of branched-chain amino acids, leading to severe symptoms like physical and mental retardation, sweet-smelling urine, and metabolic acidosis. Treatment involves dietary restrictions and potential gene therapy. Albinism,

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In a capitalist society, metabolic interactions and exchanges are influenced by one's income and occupation quality. This separation between human existence and nature is emphasized in the relation between wage labor and capital. Marx's writings highlight how labor is essential for the metabolic int

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Dr. Somen Banerjee, Director of Public Health in London Borough Tower Hamlets, highlights the concerning liver disease mortality rates in the area, with high incidence of cirrhosis, cancer, and hepatitis B and C. The data reveals a significant burden of liver diseases such as Non-Alcoholic Fatty Liv

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Inflammatory Bowel Disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), chronic conditions with immunologic basis. This article delves into the epidemiology, pathophysiology, and differences between CD and UC, highlighting clinical features, pathology, and complications like a

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In this case study, the Atkins and Mediterranean diets are compared in terms of their impact on metabolic health. The Atkins diet focuses on low carbohydrate intake, leading to gluconeogenesis and changes in insulin levels. On the other hand, the Mediterranean diet emphasizes unsaturated fats from p

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Fabry's disease is a rare X-linked lipid storage disorder characterized by deficient lysosomal alpha-galactosidase A activity. This condition primarily affects males, leading to chronic kidney disease and progression to end-stage renal disease. Kidney involvement is a critical aspect, and high doses

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