Understanding Phenytoin Therapy - Clinical Pharmacokinetics and Serum Concentrations
Phenytoin, a medication with high protein binding and hepatic metabolism, exhibits saturated pharmacokinetics with a narrow therapeutic range of 10-20 µg/mL for total serum concentrations. Adverse effects vary with serum levels: minor CNS depression at >15 µg/mL, nystagmus at >20 µg/mL, and ataxi
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Polymerization of Hexamethylene Diisocyanate in Solution and Its Impact on Human Cells
This study investigates the polymerization of hexamethylene diisocyanate (HDI) in solution and its interaction with exposed human cells. Multiple mass spectrometry analyses reveal the formation of phosphate adducts of hydrolyzed HDI, dimeric hydrolyzed HDI, and reaction products in the presence or a
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Understanding Quantitative Determination of Total Proteins in Serum
Serum total protein testing is essential for measuring the total protein content in blood, consisting of albumin and globulins. This test evaluates body health by assessing the levels of these vital proteins, aiding in diagnosing various health conditions. Learn about the significance of total prote
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