Adjuvant Immunotherapy for Resectable NSCLC
Explore the benefits and considerations of adjuvant immunotherapy in the treatment of resectable non-small cell lung cancer (NSCLC). Review the latest clinical trials, including IMpower 010 and Checkmate 816, and learn about the potential role of neoadjuvant therapy.
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Dostarlimab 7.5 mg /5 ml: Transforming Cancer Care Landscape in India
Cancer care in India is undergoing a paradigm shift with the introduction of a new immunotherapy treatment: Dostarlimab. This potent formulation (7.5 mg\/5 ml) promises to change the treatment paradigm for oncologists as well as patients fighting cancer. Dostarlimab 7.5 mg\/5 ml is a revolutionary i
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Oncological Perspective on Invasive Lobular Carcinoma: Challenges and Response to Chemotherapy
Guidelines and characteristics of invasive lobular carcinoma, focusing on oncological challenges, response to chemotherapy, and prognosis after neo-adjuvant treatment in patients. Highlights the importance of considering histology type for tailored treatment decisions. Discusses the effectiveness of
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Revolutionizing Oncology: The Growth of the Global Cancer Immunotherapy Market
The Global Cancer Immunotherapy Market was valued at $39.86 billion in 2017 and is anticipated to reach $170.70 billion by 2028 during the forecast period of 2017-2028 and still the market is showing an increase in the ROI in the later years as well.
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Advances in Perioperative Treatment of Lung Cancer: A Comprehensive Review
Explore the evolution of perioperative treatment for lung cancer from historical perspectives to current advancements. Learn about the efficacy of different chemotherapy agents, immunotherapies, and adjuvant treatments, along with the impact on patient outcomes and resectability criteria. Discover t
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POSNOC & ATNEC Trials Update by Amit Goyal: Investigating Axillary Treatment in Breast Cancer
POSNOC (Positive Sentinel Node) and ATNEC trials are investigating the effectiveness of axillary treatment in women with early-stage breast cancer having metastases in one or two sentinel nodes. Led by Chief Investigator Amit Goyal in the UK, this randomized controlled trial compares adjuvant therap
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Molecularly-Guided Therapy vs Platinum Chemotherapy in CUP Patients
This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with
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Update on Pain Management in Primary Healthcare
The updates to the 2014 Primary Healthcare Implementation Slides focus on pain control for children, including the addition of ibuprofen and exclusion of tramadol for moderate pain. The management of acute severe pain involves retaining morphine injection while omitting metocloperamide, paracetamol,
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Understanding Adjuvants and Herbicide Formulation
Adjuvants are additives that enhance herbicide effectiveness, crucial for optimal weed control. Types include surfactants, stabilizing agents, coupling agents, humectants, deposit builders, and more. Surfactants aid in wetting and spreading herbicides, stabilizing agents keep suspensions intact, cou
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Extended Endocrine Therapy Guidelines for Breast Cancer Patients
Extended adjuvant endocrine therapy may benefit breast cancer patients with poor or intermediate prognosis, but may have little value for those with good prognosis. Risks include osteoporosis and venous thromboembolism. Different treatment options are available for postmenopausal and premenopausal w
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Adjuvant Therapies in Early Stage NSCLC: A Review
Examining the role of adjuvant therapies in stage IB-IIIA non-small cell lung cancer (NSCLC) post-surgery. Discussion includes the impact of chemotherapy and radiation therapy on overall survival rates and the historical context of adjuvant treatment decisions. Management strategies and consideratio
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Can Multigene Tests Guide Adjuvant Treatment in Early Breast Cancer?
Breast cancer is heterogeneous, and predicting outcomes using clinical and pathologic features can be challenging. Genomic tests such as Oncotype DX, PAM50, and MammaPrint have been developed to aid in treatment decisions since 2002. Studies like the NSABP B-14 and B-20 trials have shown the benefit
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Pharmacotherapy Overview of Parkinson's Disease and Related Disorders
Overview of pharmacological treatment options for Parkinson's disease and related conditions like choreatic dyskinesias, spastic disorders, and myasthenia gravis. Describes the degenerative process of Parkinson's disease, its symptoms, and the pharmacological interventions targeting dopamine deficit
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Evolution of Immunotherapy in Cancer Treatment
The history and advancements in cancer immunotherapy are highlighted, from early observations in the 1890s to the development of modern immunotherapies in the 2000s. Concepts such as immunosurveillance theory and the role of T cells in recognizing tumor-associated antigens are discussed, leading to
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Advanced Cancer Therapy in India: The Promise of Enfortumab Vedotin 20/30 mg
Enfortumab vedotin 20\/30 mg is an innovative treatment for advanced urothelial carcinoma. Targeting the Nectin-4 protein, it delivers a cytotoxic agent directly to cancer cells, reducing toxicity to healthy tissues. Available in India, Enfortumab vedotin 20\/30 mg in India has shown improved surviv
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Advances in Veterinary Oncology: Understanding and Treating Spontaneous Cancers in Animals
Veterinary oncology, led by Prof. David Killick, delves into the realm of spontaneous cancers in dogs, cats, and horses, mirroring the cancer evolution in humans. The field covers diagnosis through cytology and imaging to treatments like surgery, radiation, and emerging immunotherapy. University vet
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Advancements in Cholangiocarcinoma Treatment Trials
Recent clinical trials such as TOPAZ-1, KEYNOTE-966, ClarIDHy, and FIGHT-202 have shown promising results in the treatment of cholangiocarcinoma. Trials with immunotherapy and targeted therapy have demonstrated improved overall survival rates, progression-free survival, and objective response rates
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Understanding Treatment Options for Stage III Rectal Cancer
Explore the potential treatments for a 83-year-old male diagnosed with Stage III rectal cancer, including surgery, radiation therapy, chemotherapy, and immunotherapy. Learn about neoadjuvant and adjuvant therapies, complete response definitions, surgical techniques like total mesorectal excision (TM
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Uveal Melanoma Guideline Update 2022: Summary & Recommendations
This update focuses on the guideline development process for uveal melanoma, detailing the methodology employed by the Guideline Development Group led by experts in the field. The group consists of renowned professionals from various medical backgrounds. The new recommendations touch on aspects like
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Durvalumab Plus Tremelimumab in Advanced Neuroendocrine Neoplasms: The DUNE Trial at ESMO 2020
A multi-cohort phase 2 study presented at ESMO 2020 evaluated the combination of durvalumab and tremelimumab in patients with advanced neuroendocrine neoplasms. The DUNE trial assessed the efficacy of this immunotherapy approach in various neuroendocrine tumor types, emphasizing the potential benefi
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Comprehensive Guide on Blinatumomab 35 mcg Injection in India for Cancer
Blinatumomab 35 mcg Injection in India is a breakthrough immunotherapy used primarily to treat relapsed or refractory B-cell precursor Acute Lymphoblastic Leukemia (ALL). This guide covers its mechanism, benefits, dosage, and availability in India. D
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The Impact of the Opium Wars and Pain Management Drugs
The Opium Wars were pivotal conflicts between China and Britain due to opium trade. Learn about the devastating effects of opium addiction on China's population. Explore the classes of drugs used in pain management, including NSAIDs and adjuvant drugs, to understand the importance of treating pain a
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Summary of NSABP Protocols in Breast Cancer Studies
NSABP conducted various adjuvant and neoadjuvant trials (B-15, B-18, B-22, B-23, B-28, B-30, B-27, B-40) involving different treatment arms and patient populations with operable breast cancer. Trials included chemotherapy regimens with Adriamycin, cyclophosphamide, tamoxifen, and radiation therapy,
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Comprehensive Overview of Immunotherapy in Bladder and Renal Cancer Management
Explore the latest advancements in immunotherapy for managing bladder and renal cancer, including mechanisms of action, indications, adverse effects, and available treatment regimes. Learn about immune checkpoint inhibitors, differentiating immunotherapy from chemotherapy, indications for use across
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