Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

2 views • 14 slides

Immune deficiencies can be classified into primary hereditary disorders based on clinical presentations, including cell-mediated, antibody-mediated, non-specific, and complement activation deficiencies. Major clinical manifestations of immune disorders range from B-cell deficiencies to phagocytic ce

2 views • 46 slides

Explore the fundamentals of immunology with insights into immunogens, antigens, epitopes, and haptens. Uncover how these key components play vital roles in shaping immune responses and learn about paratopes, the basis of immunogenicity, and the key events that determine foreignness in the immune sys

0 views • 15 slides

Immune Thrombocytopenia (ITP) is a rare autoimmune disease where the immune system wrongly attacks platelets, leading to low platelet count. It can affect individuals of all ages, with symptoms appearing post-virus, vaccination, or certain medications. ITP can result in fatigue, bruising, and bleedi

3 views • 30 slides

Somerset Foundation Trust Community offers a comprehensive range of services, including Rapid Response, Urgent Community Response (UCR), and Hospital@Home (H@H). These services aim to provide timely and effective care to individuals in their homes, reducing the need for hospital admissions. Rapid NH

15 views • 6 slides

In today's world, prioritizing our well-being and immune health is paramount. We constantly seek natural ways to fortify our defenses and embrace a healthy lifestyle. Noni Elixir steps forward with a powerful contender \u2013 Noni juice, a traditional beverage rich in potential benefits, including s

0 views • 2 slides

Dive into the world of immune system glossary terms with definitions and visual aids. Explore key concepts such as immune cell activation, adaptive immune response, antibodies, antigens, and more. Understand the complex processes within the immune system through informative images and concise explan

1 views • 70 slides

The immune system acts as a defense mechanism against pathogens and infections, comprising various organs, such as the bone marrow, thymus, spleen, white blood cells, antibodies, complement system, and the lymphatic system. It works to recognize and destroy harmful microbes, maintaining the body's h

1 views • 23 slides

Immunology is the study of the immune system, its functions, and responses to various stimuli. The field traces back to ancient times, with historical figures like Thucydides and Edward Jenner contributing to its development. From innate immunity to adaptive responses, the immune system plays a cruc

0 views • 29 slides

Acquired immunity, also known as adaptive immunity, is the resistance developed by an individual to foreign molecules. It involves antigenic specificity, diversity, immunologic memory, and self/non-self recognition. The two main types of acquired immunity are active immunity, developed from antigeni

1 views • 17 slides

Lymphoid organs play a crucial role in the defense mechanisms of finfish and shellfish by generating immune cells. Different types of fish vary in their lymphoid organ structures, with jawless fish relying on lymphoid tissue within other organs for immune cell production. Cyclostomes, like hagfish a

1 views • 24 slides

Hereditary Connective Tissue Disorder, Hypermobile Ehlers-Danlos Syndrome (hEDS), and Mast Cell Activation Syndrome (MCAS) are three complex conditions with overlapping symptoms affecting collagen, joint laxity, and immune responses. Features associated with these conditions include joint pains, gas

2 views • 8 slides

Antigens are substances that stimulate the production of antibodies in the body, exhibiting specificity in immune reactions. They interact with immune response products like antibodies, BCRs, and TCRs. Immunogens induce detectable immune responses, leading to antibody production or T cell activation

1 views • 30 slides

Understanding how parasites evade the immune system of their hosts is crucial in the field of immunoparasitology. Parasites have developed various strategies such as anatomical seclusion, antigenic variation, and intracellular living to avoid host immune responses. Examples include Plasmodium within

0 views • 26 slides

Malnutrition is common in people living with HIV and TB, exacerbating immune suppression and disease progression. Good nutrition can strengthen the immune system, improve drug adherence, and manage symptoms, while poor nutrition weakens immunity and increases vulnerability to infections. Consequence

2 views • 20 slides

Cytokines and chemokines are essential signaling molecules that play crucial roles in immune responses. This content covers their general properties, classification, functions, and implications in diseases and therapies. Learn about the diverse families of cytokines, cytokine antagonists, and the va

0 views • 35 slides

Cytokines play a crucial role in immune response activation and regulation. They are secreted by various cell types like lymphocytes, monocytes, and macrophages, exerting diverse biological functions, including immune system development, inflammatory response induction, and hematopoiesis regulation.

2 views • 12 slides

Autoimmunity refers to the immune system's failure to recognize its own cells, leading to attacks on self-tissues. Autoimmune disorders encompass over 80 chronic illnesses where the immune system mistakenly targets organs. These disorders are poorly understood and recognized, impacting various organ

1 views • 20 slides

The immune system maintains a balance through tolerance mechanisms to prevent autoimmunity. Central and peripheral tolerance play crucial roles in immune unresponsiveness to self-antigens. Failure in immune regulation can lead to autoimmune diseases like diabetes and lupus. Vaccination, discovered b

0 views • 18 slides

Hypersensitivity in immunology refers to an altered immune response against antigens, leading to hyperreactivity and immunopathology. This article delves into the different categories of adaptive hypersensitivities, focusing on Immediate (Type I), Antibody-Mediated Cytotoxic (Type II), and Immune Co

0 views • 6 slides

Parasitic infections pose complex challenges to the immune system due to the diverse nature of parasites, including protozoans and helminths. Protozoan parasites move between arthropod vectors and mammalian hosts, requiring both humoral and cell-mediated immune responses. Meanwhile, helminths, as mu

0 views • 15 slides

Explore the intricate details of white blood cells (WBCs), their types, functions, formation, and crucial role in defending the body against infections. Delve into the immune system, comprising barriers, cells, tissues, and organs that combat invaders, with a focus on innate and adaptive immunity. L

0 views • 65 slides

Our health is closely linked to the gut microbiome, with fiber playing a key role in feeding beneficial gut bacteria. Incorporating anti-inflammatory polyphenols from plant-based sources like fruits, vegetables, and herbs can promote a healthier gut. Additionally, fermented foods act as natural prob

1 views • 8 slides

The article discusses mucogingival surgery and perio-plastic procedures, focusing on issues like aberrant frenum, inadequate attached gingiva, and shallow vestibule. It explores the importance of these surgical interventions in addressing gingival inflammation, recession, and other mucogingival prob

0 views • 45 slides

Explore the intricate workings of the immune system, from its component parts and defense mechanisms to the significance of homeostasis maintenance. Discover how non-specific and specific immune responses, phagocytosis, neutrophils, natural killer cells, and interferons play vital roles in protectin

0 views • 32 slides

Delve into the challenges of aberrant weather in rainfed areas, exploring soil and climatic conditions, water harvesting techniques, and contingency crop planning. Discover the impact of erratic rainfall patterns on crop growth and learn about midseason corrections to mitigate adverse effects. Explo

0 views • 24 slides

Cryptococcal Immune Reconstitution Inflammatory Syndrome (C-IRIS) is a condition where rapid reversal of immunodeficiency triggers exaggerated inflammatory reactions in response to Cryptococcus antigens. It can manifest as either Unmasking IRIS or Paradoxical IRIS, with common CNS presentations incl

0 views • 10 slides

The process of hematopoiesis involves the lifelong production, multiplication, and specialization of different blood cells in the bone marrow, starting with the stem cells. This process includes the differentiation and proliferation of various progenitor cells, regulated by hematopoietic growth fact

0 views • 27 slides

The study explores the immunotoxic effects of industrial effluents on fin fish, highlighting xenobiotics' impact on the immune system. It discusses the sensitivity of the immune system to environmental toxins and the elicitation of immune reactions by various substances. The importance of fish as a

0 views • 25 slides

This PowerPoint presentation contains confidential information on optimizing the immune system to enhance overall health. It outlines a holistic approach involving neurological organization, meridian testing, and spectroscopic emission to support well-being. The content emphasizes the importance of

0 views • 27 slides

This collection of supplementary figures provides detailed flow cytometry data on immune cell populations, including CD4+ T cells, CD8+ T cells, tumor-associated macrophages, and more. The figures also include information on immune checkpoint molecules like PD-L1 and TIGIT. Each figure presents spec

0 views • 4 slides

Stem cell transplantation involves addressing the issue of immune cells failing to recognize and eliminate tumor cells, known as "The Bad Boys." By removing the dormant immune cells and replacing them with new ones from a compatible donor, the therapy aims to empower the immune system to target and

0 views • 8 slides

The inflammatory response is a crucial defense mechanism of the immune system. It comprises three lines of defense aimed at protecting the body from harmful pathogens. When a barrier is breached, such as by a splinter carrying bacteria, the inflammatory process is initiated. This includes the releas

0 views • 25 slides

Explore the different stages of the immune response, starting with macrophages in the innate immune system that act fast without memory. Follow the path to the spleen and lymph nodes where T cells, already educated at birth to recognize specific antigens, await. Witness the intricate dance of the im

0 views • 18 slides

Pathogens, such as bacteria, viruses, and fungi, can cause infectious diseases in humans, animals, and plants. The immune system defends against these pathogens through various mechanisms, including the production of antibodies, phagocytosis, and the activation of specific defense cells like white b

0 views • 4 slides

The lymphatic system, a vital component of the immune system, consists of lymphocytes, plasma cells, and other cells within a framework of reticular cells and fibers. It includes lymphoid organs like the bone marrow, thymus, lymph nodes, and spleen. Diffuse lymphatic tissue and lymphatic nodules are

0 views • 20 slides

The lymphatic system plays a crucial role in returning leaked fluids back to the blood, protecting the body from foreign materials, and supporting immune surveillance. It consists of lymphoid cells such as T and B lymphocytes, macrophages, dendritic cells, and reticular cells that work together to d

0 views • 31 slides

The lymphatic system plays crucial roles in maintaining fluid balance, immune response, and waste removal in the body. Comprised of lymphatic vessels and organs, this interconnected system transports lymph fluid from tissues back to the bloodstream. Lymph capillaries, lymph nodes, and larger collect

0 views • 22 slides

Helminths, parasitic organisms affecting a large part of the global population, can modify the immune response through immunomodulation. This research delves into the interaction between helminths, microbiome, and immune response, exploring the effects on macrophages, alternative activation, and the

0 views • 28 slides

Study focuses on Canine Meningoencephalitis of unknown etiology using Pan-Viral PCR to detect infectious agents in cerebrospinal fluid samples. The research aims to identify aberrant immune responses in dogs with MUE. Consensus degenerate primers are used to target viral families like Herpesviridae,

0 views • 13 slides