Exploring Protein Modeling in Sickle Cell Genotype

Dive into the world of protein modeling to understand why some individuals with the sickle cell genotype remain asymptomatic. Explore amino acid sequences, build typical and sickle cell protein segments, and visually represent the changes in protein structure. Hands-on instructions guide you through the process step by step.

• Protein Modeling
• Sickle Cell Genotype
• Amino Acids
• Genetic Disorders
• Bioinformatics

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Uploaded on Sep 25, 2024 | 0 Views

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1. PART 5: Modeling Proteins From Why Do Some People with the Sickle Cell Genotype Not Have Symptoms?

2. Modeling Proteins Background You will use this amino acid key for your model. As shown, each amino acid has a specific shape represented by three boxes.

3. Modeling Proteins Background The first amino acid in a sequence can be placed anywhere you like. Each new amino acid should be placed with its first box (start of the arrow) connected to the last box (end of the arrow) of the previous amino acid, in the direction of the previous amino acid s arrow. Met, Asp would look like this (first box for Asp is connected below Met because Met s arrow pointed down). Met, Asp, Cys, Tyr would look like this.

4. Modeling Proteins Instructions Using the amino acid sequences you translated in Part 4: Build the typical protein segment (using the sequence in Table 2) on the next slide. Build the sickle cell protein segment (using the sequence in Table 3) on the slide after the next slide. To build each protein segment, select and drag the amino acids on the slides into the positions you want. You can copy-and-paste amino acids as needed. Only the amino acids needed for these protein segments are included on the slides that follow.

5. Modeling Proteins Typical protein (from Table 2)

6. Modeling Proteins Copy or drag this circle over the point at which the shape of the sickle cell protein first changes from the typical one. Sickle cell protein (from Table 3)