Understanding Mixed Connective Tissue Disease (MCTD)

Mixed connective tissue disease (MCTD), also known as Sharp's syndrome, is a rare inflammatory rheumatic disease diagnosed through clinical evaluation, patient history, or special blood tests. Symptoms include overlapping connective tissue disease symptoms, with main cause being autoimmunity. It can affect anyone but is commonly diagnosed in women under 30. Treatment options include corticosteroids, nonsteroidal drugs, or immunosuppressive drugs for severe cases.

• MCTD
• Autoimmunity
• Inflammatory Disease
• Connective Tissue
• Corticosteroids

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1. MIXED CONNECTIVE TISSUE DISEASE By Elly Kim, Abby Hook, and ChristiannaSwift

2. What is it? Mixed connective tissue disease (MTCD), also known as Sharp s syndrome, is a very rare systemic inflammatory rheumatic disease and can be diagnosed by clinical evaluation, patient history, or special blood tests (Mixed Connective Tissue Disease). (Mixed Connective Tissue Disease: MCTD Explained)

3. What are the Symptoms? The symptoms of mixed connective tissue disease include symptoms which overlap with two or more connective tissue diseases because of the nature of the disease. These symptoms may include blue or white color changes in painfully cold fingers and toes which occurs in 90% of people with MCTD (Mixed Connective Tissue Disease). (Rheumatoid Arthritis) (Mixed Connective-Tissue DiseaseClinical Presentation)

4. What Causes it? The main cause of MCTD is autoimmunity, described by when your immune system mistakenly attacks your body's healthy cells (Mixed Connective Tissue Disease). (Autoimmunity)

5. Who is Affected? This can affect anybody, since there is no known cause of this disease; however, it is more commonly diagnosed inwomen under the age of 30 (Mixed Connective Tissues Disease). (Graph displaying the age of individuals affected by MCTD) (Epidemiology of MCTD)

6. What are treatment options? Corticosteriods are effective and used when the disease is diagnosed in the early stages. Mild cases can be treated with nonsteroidal drugs or corticosteriods. Severe cases will require high doses of corticosteroid and immunosuppressive drugs. (Mixed Connective Tissue Disease (MCTD) - Bone, Joint, and Muscle Disorders). (Corticosteroids)

7. Works Cited Admin.Rheumatoid Arthritis, Lupus and Mixed Connective Tissue Disease (MCTD). Digital image.Arthritic Chick. Arthritic Chick, 3 Oct. 2012. Web. 06 June 2017. <http://www.arthriticchick.com/diagnoses/rheumatoid-arthritis/rheumatoid-arthritis-lupus-and-mixed-connective-tissue-disease-mctd>. Autoimmunity. Digital image. Many Infinities. Many Infinities, Web. 6 June 2017. <https://www.manyinfinities.org/autoimmunity.html>. Corticosteroids. Digital image.Allergy Bangladesh. The 1 Hospital and Allergy Bangladesh, Web. 6 June 2017.<http://www.allergybangladesh.com/corticosteroids/>. Gunnarsson, Ragnar, yvind Molberg, Inge-Margrethe Gilboe, and Jan Tore Gran. Graph displaying the age of individuals affected by MCTD. Digital image.The prevalence and incidence of mixed connective tissue disease: a national multicentresurvey of Norwegian patients. BMJ Publishing Group Ltd & European League AgainstRheumatismBMJPublishing Group Ltd & European League Against Rheumatism, 11 Mar. 2011. Web. 6 June 2017. <http://ard.bmj.com/content/70/6/1047>. Mixed Connective-Tissue DiseaseClinical Presentation.Digital image. Mixed Connective-Tissue Disease Clinical Presentation. WebMD, 08Jul. 2016. Web. 06 June 2017.<http://emedicine.medscape.com/article/335815-clinical>. Mixed Connective Tissues Disease. Mayo Clinic, Mayo, www.mayoclinic.org/diseases-conditions/mixed-connective-tissue- disease/basics/definition/con-20026515. Accessed 6 June 2017. "Mixed Connective Tissue Disease (MCTD) - Bone, Joint, and Muscle Disorders." Merck Manuals Consumer Version. Web. 06 June 2017. Mixed Connective Tissue Disease: MCTD Explained. Digital image. Molly's Fund. Molly's Fund Fighting Lupus, 20 Dec. 2016. Web. 06 June 2017. <http://www.mollysfund.org/2014/06/mixed-connective-tissue-disease/>. "Mixed Connective Tissue Disease." NORD (National Organization for Rare Disorders). NORD - National Organization for Rare Disorders, 2017. Web. 06 June 2017. <https://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/>. Murphy, Griffin. Epidemiology of MCTD. Digital image. SlidePlayer. Slideplayer.com, June 2016. Web. 6 June 2017. <http://slideplayer.com/slide/10660436/>.