National Histopathology Service for Organ Retrieval and Transplantation - Audit Findings

The need for a national histopathology service for organ retrieval and transplantation is highlighted, with a focus on the importance of histopathological analysis in assessing donor organ quality and identifying lesions for further investigation. The audit findings show the incidence of urgent histopathological analysis requests, the utilization of retrieved organs following histology, and the impact of an out-of-hours histopathology service on donor/organ utilization and recipient safety.

• Histopathology
• Organ Retrieval
• Transplantation
• Audit Findings
• Organ Quality

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1. The case for a National Histopathology Service for organ retrieval and transplantation. Philip Whatling On behalf of NHA Team & audit champions

2. Introduction Unexpected lesions that require further characterisation may be identified during organ retrieval or at examination of the organ in the transplant centre. Further assessment of donor organ quality may also be required. Histopathological analysis may therefore become necessary at time of retrieval or before safe transplantation may proceed. No formal process in the UK for obtaining out-of-hours histopathological report of retrieved organs

3. Introduction Histopathological report may become necessary when: a) A lesion suspicious for malignancy is identified Type I b) Further assessment of organ quality is required Type II It is unknown whether urgent histopathological analysis enables the utilisation of donor organs that would otherwise have been discarded.

4. The National Histopathology Audit Define current incidence of urgent* histopathological analysis requests. Define numbers of retrieved organs utilised following histology. Identify impact of an out-of-hours histopathology service on: Donor/organ utilisation Recipient safety Urgent biopsies were defined as those biopsies were the report was awaited in order to proceed either for retrieval or for transplantation.

5. Methods Prospective data collection 1stOctober 2013 and 31stMarch 2014 (6mo) All NORS team retrievals All Transplant Centres.

6. Results 100% Data Return 654 Retrievals 2322 Organs Retrieved Utilised: 2064 (88%) Taken, Accepted and Not Utilised: 258 (12%)

7. Results - Incidence 142 urgent biopsies in 654 retrievals (21.7%) 42 Type 1 Biopsies (29.6%) 100 Type 2 Biopsies (70.4%) 51% out-of-hours (1900 to 0700 and weekends)

8. Results - Incidence 95% biopsies sent to pathology services at NORS centres The organs biopsied at Transplant Centres were mostly Livers and Kidneys There was only one biopsy taken at CT Transplant Centre No biopsies from Pancreases

9. Results biopsy incidence by age 8 24 6 68 20 16 Type 2 Biopsy 28 99 210 Type 1 Biopsy 175 No Biopsy 0 to 19 20 to 39 40 to 59 >60 Donor Age

10. Results biopsy incidence by donor type DBD (n=390) DCD (n=264) 7% 5% 14% 18% Type 1 Type 1 Type 2 Type 2 No Biopsy No Biopsy 77% 79% 56% Biopsies were performed on DBD organs 44% Biopsies were performed on DCD organs

11. Results Type 1 Biopsy 42/654 Biopsies for suspected malignancy (6.4%) 3/654 Malignancies identified (0.45%) 3/42 Biopsies confirmed malignancy (7%) There were 119 organs safely transplanted thanks to negative Bx report

12. Results Type 2 Biopsy 100 Type 2 Biopsies 22 liver 78 kidney Unsuitable organ quality in 5% (4 kidneys;1 liver) 21 Livers and 74 Kidneys utilised following Type 2 Biopsy

13. Results Organ specific (kidney) 40-59 Age group: 28/480 Not Utilised 452/480 Utilised 32 Type 1 Biopsies 18 Type 2 Biopsies >60 Age group: 59/465 Not Utilised 406/465 Utilised 27 Type 1 Biopsies 52 Type 2 Biopsies

14. Results Organ specific (liver) 40-59 Age group: 14/197 Not Utilised 183/480 Utilised 9 Type 1 Biopsies 11 Type 2 Biopsies >60 Age group: 30/165 Not Utilised 135/465 Utilised 10 Type 1 Biopsies 23 Type 2 Biopsies

15. Discussion key points First data collected on national use of histopathology service for transplantation. Significant use of histopathology during audit period Older donors trigger biopsies Mostly type 2 biopsies Potentially significant decrease in inappropriate non-utilisation of organs?

16. Discussion future questions National Retrieval Group has constituted a steering group How significant is the role of an accessible national pathology service in increasing organ utilisation? Pilot Further evidence Service evaluation/development Logistics Does such a service translate into improved graft/patient outcomes? Prospective study linked to the service evaluation project Retrospective analysis on biopsies already available

17. Acknowledgements NHA Team: Sarah Jones, Andrew Rayner, Ahmed Ali, Chris Callaghan, Rajesh Sivaprakasam and Roberto Cacciola Audit Champions: Gavin Pettigrew, Magdi Attia, Wayel Jassem, Hynek Mergental, Elijah Ablorsu, Majid Mukadam, Habib Kashi, Karen Stevenson, Yarwood Gemma, Pissanou Theodora, Nikhil Patil, Mr Al Attar, Bimbi Fernando, Roufosse, Candice, Mohammed Morsy, Gourab Sen, Katie McGoohan, Fletcher Nicholas, Tanveer Butt, Ali Machaal, Mehra Sanjay, Simon Boyes, Andrew Sutherland, Kourosh Saeb-Parsy, Catherine Sudarshan, Amanda Knight, Rajesh Sivaprakasam, Rajinder Singh, Srinivasan Parthi, Callaghan Christopher, Graetz Keith, Linda Boorer, Omar, Mohie, Nick Inston