Comprehensive Overview of Parkinson's Research and Conference Highlights
Delve into the world of Parkinson's research with insights from the Neuroprogressive & Dementia Research Network Conference. Explore the key messages, disease characteristics, symptoms, and the importance of ongoing research in understanding and treating Parkinson's disease. Discover the latest studies, clinical trials, and the collaborative efforts in Scotland to address the unmet needs in Parkinson's care.
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Parkinsons Research: the Neuroprogressive & Dementia Research Network Celebrating Scottish Research Conference 13 June 2024 Gordon Duncan NHS Lothian & University of Edinburgh
NHS Lothian NRS Clinician NHS Lothian PI clinical studies Lecture & Travel fees: GE Healthcare and Bial Disclosures
Key messages Parkinson s is a common neurodegenerative disorder Complex disease (s): many body systems involved, and everyone s experience is different Research is vital to better understand how Parkinson s evolves and develop better treatments NDN supports an expanding portfolio of clinical studies for Parkinson s and related disorders in Scotland
Parkinsons disease 1817 Dr James Parkinson Loss of neurones Dopaminergic Cholinergic Noradrenergic Serotonergic
Bradykinesia Walking, manual dexterity, speech, swallowing, self-care Tremor Motor & Movement Resting Rigidity Stiffness in limbs Postural instability and falls
Cognitive & Neuropsychiatric Dementia, cognitive impairment, depression, anxiety, apathy, hallucinations, delusions, psychosis Non Motor Features Autonomic Constipation, urinary urgency, orthostatic hypotension, sweating, fatigue Sleep Rapid eye movement sleep behaviour disorder, excess daytime sleepiness, sleep fragmentation
Research is vital to address unmet needs 1.Therapies to stop, slow or reverse the pathological progression of Parkinson s 2.Better treatments of complex motor problems 3.Effective treatments for non-motor features Constipation, sleep, mood, memory, thinking, sleep, low blood pressure, urinary, sweating
Parkinsons studies and the NDN Symptoms: Motor and Non-motor Disease modifying Complex motor: AbbVIe Pump Bial - Activate Luma/Lighthouse Falls: CHIEF-PD PADOVA Exenatide Voice and Speech: PD COMM PD Probiotic Urinary symptoms: START-UP ASPro EJS-ACT (PD MAMS) PD Dementia: COBALT Understanding PD and Genetics Hallucinations: TOPHAT and CANPDP ROPAD Deep Brain Stimulation: Vercise LIPAD PD Frontline
Delivering research excellence in NHS Lothian Permission to Contact o A tri-fold leaflet developed for patients o Person completes Permission to Contact form o Registers their interest in research o Details held on a secure database in HIC o No obligation to take part o Gives NDN permission to contact you about research o PTC forms can be sent out with appointment letters or given to patients during or after clinic visits @NHSResearchScot NHS Research Scotland www.nrs.org.uk
Research Interest Groups throughout Scotland
Parkinsons UK https://www.parkinsons.org.uk/research/take-part- research Research Interest Groups Research Information: UK and beyond https://www.edinburghparkinsons.org/research- interest/ Cure Parkinson s https://cureparkinsons.org.uk/ Michael J Fox Foundation https://www.michaeljfox.org/ No Silver Bullet https://nosilverbullet4pd.com/
Thank you Thank you
Parkinsons Research: the Neuroprogressive & Dementia Research Network Celebrating Scottish Research Conference 13 June 2024 Gordon Duncan NHS Lothian & University of Edinburgh
NHS Lothian NRS Clinician NHS Lothian PI clinical studies Lecture & Travel fees: GE Healthcare and Bial Disclosures
Key messages Parkinson s is a common neurodegenerative disorder Complex disease (s): many body systems involved, and everyone s experience is different Research is vital to better understand how Parkinson s evolves and develop better treatments NDN supports an expanding portfolio of clinical studies for Parkinson s and related disorders in Scotland
Parkinsons disease 1817 Dr James Parkinson Loss of neurones Dopaminergic Cholinergic Noradrenergic Serotonergic
Bradykinesia Walking, manual dexterity, speech, swallowing, self-care Tremor Motor & Movement Resting Rigidity Stiffness in limbs Postural instability and falls
Cognitive & Neuropsychiatric Dementia, cognitive impairment, depression, anxiety, apathy, hallucinations, delusions, psychosis Non Motor Features Autonomic Constipation, urinary urgency, orthostatic hypotension, sweating, fatigue Sleep Rapid eye movement sleep behaviour disorder, excess daytime sleepiness, sleep fragmentation
Research is vital to address unmet needs 1.Therapies to stop, slow or reverse the pathological progression of Parkinson s 2.Better treatments of complex motor problems 3.Effective treatments for non-motor features Constipation, sleep, mood, memory, thinking, sleep, low blood pressure, urinary, sweating
Parkinsons studies and the NDN Symptoms: Motor and Non-motor Disease modifying Complex motor: AbbVIe Pump Bial - Activate Luma/Lighthouse Falls: CHIEF-PD PADOVA Exenatide Voice and Speech: PD COMM PD Probiotic Urinary symptoms: START-UP ASPro EJS-ACT (PD MAMS) PD Dementia: COBALT Understanding PD and Genetics Hallucinations: TOPHAT and CANPDP ROPAD Deep Brain Stimulation: Vercise LIPAD PD Frontline
Delivering research excellence in NHS Lothian Permission to Contact o A tri-fold leaflet developed for patients o Person completes Permission to Contact form o Registers their interest in research o Details held on a secure database in HIC o No obligation to take part o Gives NDN permission to contact you about research o PTC forms can be sent out with appointment letters or given to patients during or after clinic visits @NHSResearchScot NHS Research Scotland www.nrs.org.uk
Research Interest Groups throughout Scotland
Parkinsons UK https://www.parkinsons.org.uk/research/take-part- research Research Interest Groups Research Information: UK and beyond https://www.edinburghparkinsons.org/research- interest/ Cure Parkinson s https://cureparkinsons.org.uk/ Michael J Fox Foundation https://www.michaeljfox.org/ No Silver Bullet https://nosilverbullet4pd.com/
Thank you Thank you
