Advanced Imaging Simulations for Hadrontherapy and PET Procedures

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Explore advanced FLUKA in-beam PET simulations and Hadrontherapy activity-based generator for precise treatment planning. Speed up simulations using cloud computing and bias activity-based generators for faster workstation processing. Understand components needed for hadrons treatment simulation, including spatial and time sampling, activity distribution, and photon pair generation. Enhance image reconstruction and explore alternative positron generation methods for more complete physics simulations.


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  1. FLUKA in-beam PET simulations

  2. FLUKA in-beam PET simulations Speed up the simulation Bias Activity based-generator Faster workstation Cloud-computing

  3. FLUKA in-beam PET simulations Speed up the simulation Bias Activity based-generator Faster workstation Cloud-computing

  4. Hadrontherapy activity-based generator Needed components Hadrons treatment simulation Activity scoring with time tagging SOURCE.F file for photons pair generation Post-processing Image reconstruction

  5. Hadrontherapy activity-based generator Needed components Hadrons treatment simulation Activity scoring with time tagging SOURCE.F file for photons pair generation Post-processing Image reconstruction

  6. Hadrontherapy activity-based generator Needed components Hadrons treatment simulation Activity scoring with time tagging Spatial sampling Time sampling (spills?) Activity distribution vs annihilation points distribution per nucleon Pairs generation vs positrons generation

  7. Hadrontherapy activity-based generator Needed components Hadrons treatment simulation Activity scoring with time tagging SOURCE.F file for photons pair generation Post-processing Image reconstruction

  8. Hadrontherapy activity-based generator SOURCE.F file for photons pair generation Spatial and time sampling of activity, simple pairs generation Input file contains 4D spatial sampling With REAL*4 for 100x100x100x300 voxel the memory used is 1.2 GB Alternative: activity sampled per nucleon Input file contains different data per emitter Positron generation instead of pairs -> More complete physics

  9. Hadrontherapy activity-based generator SOURCE.F file for photons pair generation Random direction generation

  10. Hadrontherapy activity-based generator SOURCE.F file for photons pair generation Sample-based activity distribution Rejection method implemented: picked 4 coordinates random within the input sampling Rejection method with the fifth number picked no Activity distribution ok

  11. Hadrontherapy activity-based generator Results: full proton treatment simulated in about 1h10 Deadline per fare la prima ricostruzione: 15 Ottobre 2014

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