The study compares the efficacy of ticagrelor monotherapy after less than 1 month of dual anti-platelet therapy (DAPT) to 12-month ticagrelor-based DAPT in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) with drug-eluting stent implantation. The aim is

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Among patients with transient ischemic attack (TIA) or minor ischemic strokes, adding ticagrelor to aspirin has shown superior efficacy in preventing stroke or death, particularly in those with ipsilateral atherosclerotic stenosis. The THALES trial demonstrated that ticagrelor added to aspirin was m

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Patients undergoing complex PCI are at high risk of ischemic events. The TWILIGHT-COMPLEX study aims to compare the safety and efficacy of ticagrelor monotherapy versus ticagrelor with aspirin in patients who completed 3 months of DAPT post-PCI. While extended DAPT may reduce ischemic events, it als

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Pharmacodynamic effects of switching P2Y12 inhibitors from ticagrelor to clopidogrel in coronary artery disease patients were investigated in the SWAP-4 study. De-escalation between these agents is common for various reasons. The study assessed the impact of clopidogrel loading dose, maintenance dos

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Study investigating the efficacy of dolutegravir (DTG) monotherapy in early HIV-1 infection showed non-inferiority compared to standard combination antiretroviral therapy (cART). The EARLY-SIMPLIFIED study involved 68 patients on DTG monotherapy and 33 on cART, with both groups achieving HIV RNA sup

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