Chromosomal Alterations and Their Impact on Phenotype
Errors in mitosis or meiosis can result in changes in phenotype, often due to alterations in chromosome structure such as deletion, duplication, inversion, and translocation. Nondisjunction can lead to abnormal chromosome number, resulting in disorders like aneuploidy. Polyploidy, with extra complet
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Understanding Numerical Chromosome Aberrations in Humans
Numerical chromosome aberrations involve the gain or loss of whole chromosomes, impacting the genome size and potentially leading to genetic mutations. Nondisjunction, where chromosomes fail to separate properly during cell division, can result in aneuploidy - the presence of an extra or missing chr
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Understanding Chromosomal Abnormalities and Syndromes
Human cells have 22 pairs of autosomes and one pair of sex chromosomes, totaling 46. Karyotypes help diagnose chromosomal abnormalities by aligning chromosomes in size order. Nondisjunction during meiosis can lead to abnormal chromosome numbers in gametes. Disorders like Down Syndrome, XYY Syndrome,
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