Ergot alkaloids are toxins produced by parasitic fungi that invade cereal crops and grasses, leading to the formation of ergot. These toxins, including ergometrine and ergotamine, have various effects on the central nervous system, smooth muscles, and overall health. Ergotism, resulting from the ing

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New Approach Methodologies (NAMs) are being developed to evaluate developmental neurotoxicity without the use of animal testing. The EPA is prioritizing efforts to reduce animal testing and is actively supporting the development of NAMs. These methodologies involve using in vitro assays to assess cr

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A 16-year-old female with T-cell ALL presented with acute right-sided weakness and slurred speech. Differential diagnoses included stroke, asparaginase toxicity, viral infections, and methotrexate neurotoxicity. Imaging revealed an area of restricted diffusion in the centrum semiovale, characteristi

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