Unraveling the Anomeric Effect: Origins and Mechanisms

The anomeric effect, discovered in 1955, reveals the preference of certain substituents in cyclohexyl systems to occupy the axial position. This phenomenon was first observed by J.T. Edward, N.-J. Chu, and R.U. Lemieux, challenging existing conceptions. The effect is attributed to hyperconjugation a

0 views • 10 slides